INT94450

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Context Info
Confidence 0.78
First Reported 2001
Last Reported 2010
Negated 13
Speculated 10
Reported most in Body
Documents 359
Total Number 404
Disease Relevance 131.85
Pain Relevance 275.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Nav1) cytoskeleton (Nav1) cytoplasm (Nav1)
Anatomy Link Frequency
nerve 46
neurons 42
sensory neurons 13
nodes 12
nociceptors 11
Nav1 (Mus musculus)
Nav1 - R896Q (2)
Pain Link Frequency Relevance Heat
sodium channel 8126 100.00 Very High Very High Very High
tetrodotoxin 3322 100.00 Very High Very High Very High
dorsal root ganglion 2817 100.00 Very High Very High Very High
nav1.8 2431 100.00 Very High Very High Very High
Nav1.7 2210 100.00 Very High Very High Very High
Inflammation 1247 100.00 Very High Very High Very High
nociceptor 1092 100.00 Very High Very High Very High
nav1.3 995 100.00 Very High Very High Very High
Nav1.2 755 100.00 Very High Very High Very High
Nav1.6 551 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 2976 100.00 Very High Very High Very High
Targeted Disruption 1475 100.00 Very High Very High Very High
INFLAMMATION 1299 100.00 Very High Very High Very High
Sprains And Strains 416 99.96 Very High Very High Very High
Inflammatory Pain 414 99.92 Very High Very High Very High
Pain 1725 99.84 Very High Very High Very High
Nociception 977 99.84 Very High Very High Very High
Cicatrix 48 99.84 Very High Very High Very High
Injury 325 99.82 Very High Very High Very High
Multiple Sclerosis 118 99.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
MNTB immunohistochemistry demonstrates that Nav1.1 subunits are expressed postsynaptically in both P14 normal and deaf mice, while postsynaptic Nav1.6 staining was only observed in deaf mice.
Gene_expression (expressed) of Nav1 in MNTB associated with deafness, nav1.1 and nav1.6
1) Confidence 0.78 Published 2006 Journal Eur. J. Neurosci. Section Abstract Doc Link 16930439 Disease Relevance 0.85 Pain Relevance 0.46
In contrast, PNS nodes are only modestly longer and, although maturation is delayed, eventually all express Nav1.6.
Gene_expression (express) of Nav1 in nodes associated with nav1.6
2) Confidence 0.78 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 12904461 Disease Relevance 0.09 Pain Relevance 0.58
Caspr mutant mice display significant abnormalities at central nodes; components of the nodes progressively disperse along axons, and many nodes fail to mature properly, persistently expressing Nav1.2 rather than Nav1.6.
Gene_expression (expressing) of Nav1 in nodes associated with congenital anomalies, nav1.2 and nav1.6
3) Confidence 0.78 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 12904461 Disease Relevance 0.10 Pain Relevance 0.58
Caspr mutant mice display significant abnormalities at central nodes; components of the nodes progressively disperse along axons, and many nodes fail to mature properly, persistently expressing Nav1.2 rather than Nav1.6.
Gene_expression (expressing) of Nav1 in nodes associated with congenital anomalies, nav1.2 and nav1.6
4) Confidence 0.78 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 12904461 Disease Relevance 0.10 Pain Relevance 0.59
In this study, we demonstrate a robust increase of sodium channel Nav1.6 expression in activated microglia and macrophages in EAE and MS.
Gene_expression (expression) of Nav1 in macrophages associated with multiple sclerosis, sodium channel and nav1.6
5) Confidence 0.78 Published 2005 Journal Glia Section Abstract Doc Link 15390090 Disease Relevance 1.27 Pain Relevance 1.02
We investigated the role of Nav1.7 expressed in nociceptors in neuropathic pain.
Gene_expression (expressed) of Nav1 in nociceptors associated with nociceptor, neuropathic pain and nav1.7
6) Confidence 0.78 Published 2005 Journal Mol Pain Section Body Doc Link PMC1215513 Disease Relevance 1.16 Pain Relevance 2.45
Therefore, the role of Nav1.7 in sensory neurons where Nav1.8 is not expressed (and which do not express Cre) remains to be studied.
Neg (not) Gene_expression (expressed) of Nav1 in sensory neurons associated with nav1.8 and nav1.7
7) Confidence 0.78 Published 2005 Journal Mol Pain Section Body Doc Link PMC1215513 Disease Relevance 0.95 Pain Relevance 2.25
This indicates that there is a population of sensory neurons, the size of which has yet to be determined, that express Nav1.7 but not Nav1.8.
Gene_expression (express) of Nav1 in sensory neurons associated with nav1.8 and nav1.7
8) Confidence 0.78 Published 2005 Journal Mol Pain Section Body Doc Link PMC1215513 Disease Relevance 0.94 Pain Relevance 2.16
Nav1.7 is expressed principally in peripheral neurons with very weak expression detected in CNS [10,11].
Gene_expression (expressed) of Nav1 in peripheral neurons associated with nav1.7
9) Confidence 0.78 Published 2005 Journal Mol Pain Section Body Doc Link PMC1215513 Disease Relevance 0.93 Pain Relevance 1.43
Expression of Nav1.7 has been reported to increase in sensory neurons subsequent to induction of inflammation [24].
Gene_expression (Expression) of Nav1 in sensory neurons associated with inflammation and nav1.7
10) Confidence 0.78 Published 2005 Journal Mol Pain Section Body Doc Link PMC1215513 Disease Relevance 1.20 Pain Relevance 1.89
Nav1.8 is expressed exclusively in sensory neurons and is not found in the CNS [9].
Gene_expression (expressed) of Nav1 in sensory neurons associated with nav1.8
11) Confidence 0.78 Published 2005 Journal Mol Pain Section Body Doc Link PMC1215513 Disease Relevance 0.83 Pain Relevance 1.24
This indicates that there is a population of sensory neurons, the size of which has yet to be determined, that express Nav1.7 but not Nav1.8.
Gene_expression (express) of Nav1 in sensory neurons associated with nav1.8 and nav1.7
12) Confidence 0.78 Published 2005 Journal Mol Pain Section Body Doc Link PMC1215513 Disease Relevance 0.94 Pain Relevance 2.17
The expression of Nav1.1, Nav1.2, Nav1.6, Nav1.7, Nav1.8 and Nav1.9 subunits is down-regulated, whereas only Nav1.3, a TTX-sensitive channel, is up-regulated following peripheral nerve injury [10-16].
Gene_expression (expression) of Nav1 in peripheral nerve associated with nav1.1, nav1.2, nav1.8, nav1.9, nav1.3, tetrodotoxin, nervous system injury, nav1.6, nav1.7 and peripheral nerve injury
13) Confidence 0.78 Published 2006 Journal Mol Pain Section Body Doc Link PMC1630424 Disease Relevance 0.82 Pain Relevance 2.29
The expression of Nav1.1, Nav1.2, Nav1.6, Nav1.7, Nav1.8 and Nav1.9 subunits is down-regulated, whereas only Nav1.3, a TTX-sensitive channel, is up-regulated following peripheral nerve injury [10-16].
Gene_expression (expression) of Nav1 in peripheral nerve associated with nav1.1, nav1.2, nav1.8, nav1.9, nav1.3, tetrodotoxin, nervous system injury, nav1.6, nav1.7 and peripheral nerve injury
14) Confidence 0.78 Published 2006 Journal Mol Pain Section Body Doc Link PMC1630424 Disease Relevance 0.82 Pain Relevance 2.29
This is thought to be a direct result of expression of Nav1.3 as it possesses similar inactivation kinetics when expressed in cell lines [18].
Gene_expression (expression) of Nav1 associated with nav1.3
15) Confidence 0.78 Published 2006 Journal Mol Pain Section Body Doc Link PMC1630424 Disease Relevance 0.39 Pain Relevance 1.86
Nav1.3 is expressed throughout the embryonic nervous system but is down-regulated in adults [11,17].
Gene_expression (expressed) of Nav1 in embryonic nervous system associated with nav1.3
16) Confidence 0.78 Published 2006 Journal Mol Pain Section Body Doc Link PMC1630424 Disease Relevance 0.60 Pain Relevance 2.14
The expression of Nav1.1, Nav1.2, Nav1.6, Nav1.7, Nav1.8 and Nav1.9 subunits is down-regulated, whereas only Nav1.3, a TTX-sensitive channel, is up-regulated following peripheral nerve injury [10-16].
Gene_expression (expression) of Nav1 in peripheral nerve associated with nav1.1, nav1.2, nav1.8, nav1.9, nav1.3, tetrodotoxin, nervous system injury, nav1.6, nav1.7 and peripheral nerve injury
17) Confidence 0.78 Published 2006 Journal Mol Pain Section Body Doc Link PMC1630424 Disease Relevance 0.82 Pain Relevance 2.30
Coinciding with the re-expression of the Nav1.3 channel in injured neurons, the voltage-gated sodium currents recover from inactivation fourfold faster than that in uninjured neurons [13].
Gene_expression (expression) of Nav1 in neurons associated with nav1.3
18) Confidence 0.78 Published 2006 Journal Mol Pain Section Body Doc Link PMC1630424 Disease Relevance 0.46 Pain Relevance 1.97
Therefore, it is hypothesized that mis-expression of VGSCs and in particular the re-expression of Nav1.3 is an important factor contributing to the hyperexcitability of injured neurons.
Gene_expression (expression) of Nav1 in neurons associated with nav1.3 and hyperexcitability
19) Confidence 0.78 Published 2006 Journal Mol Pain Section Body Doc Link PMC1630424 Disease Relevance 0.44 Pain Relevance 1.95
The expression of Nav1.1, Nav1.2, Nav1.6, Nav1.7, Nav1.8 and Nav1.9 subunits is down-regulated, whereas only Nav1.3, a TTX-sensitive channel, is up-regulated following peripheral nerve injury [10-16].
Gene_expression (expression) of Nav1 in peripheral nerve associated with nav1.1, nav1.2, nav1.8, nav1.9, nav1.3, tetrodotoxin, nervous system injury, nav1.6, nav1.7 and peripheral nerve injury
20) Confidence 0.78 Published 2006 Journal Mol Pain Section Body Doc Link PMC1630424 Disease Relevance 0.82 Pain Relevance 2.30

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