INT94453

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Context Info
Confidence 0.75
First Reported 2001
Last Reported 2010
Negated 6
Speculated 1
Reported most in Body
Documents 50
Total Number 54
Disease Relevance 18.41
Pain Relevance 4.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (ITGB1) plasma membrane (ITGB1)
Anatomy Link Frequency
chondrocytes 12
stem cells 5
fibroblast 3
hematopoietic cell 3
cartilage 2
ITGB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 166 100.00 Very High Very High Very High
Osteoarthritis 558 99.96 Very High Very High Very High
aspirin 3 99.32 Very High Very High Very High
cINOD 2 98.08 Very High Very High Very High
cytokine 113 89.68 High High
cva 108 82.24 Quite High
carpal tunnel syndrome 1 79.56 Quite High
ischemia 73 78.64 Quite High
Inflammation 153 77.04 Quite High
Spinal cord 77 75.68 Quite High
Disease Link Frequency Relevance Heat
Knee Osteoarthritis 540 99.96 Very High Very High Very High
Osteoarthritis 189 99.72 Very High Very High Very High
Obesity 116 99.24 Very High Very High Very High
Peripheral Arterial Disease 105 98.96 Very High Very High Very High
INFLAMMATION 171 97.88 Very High Very High Very High
Necrosis 43 97.76 Very High Very High Very High
Shock 79 97.74 Very High Very High Very High
Cancer 131 97.40 Very High Very High Very High
Adhesions 61 92.80 High High
Diabetes Mellitus 73 92.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expressions of specific genes, shown to be regulated in the cDNA array analysis, were analyzed in the individual samples using real-time PCR. cDNA arrays showed that gene expressions for matrix-metalloproteinase-2 (MMP-2), fibronectin subunit B (FNRB), vascular endothelial growth factor (VEGF), and mitogen-activated protein kinase p38 (MAPKp38) were up-regulated, while matrix-metalloproteinase-3 (MMP-3) and decorin were down-regulated, in tendinosis tissue compared with control tissue.
Gene_expression (expressions) of FNRB associated with metalloproteinase and tendinopathy
1) Confidence 0.75 Published 2003 Journal J. Orthop. Res. Section Abstract Doc Link 14554207 Disease Relevance 0.65 Pain Relevance 0.38
Although they expressed CD29 and CD90, a majority of adherent cells were negative for CD34 and CD45, which is consistent with MSCs previously reported (8,21).


Gene_expression (expressed) of CD29
2) Confidence 0.75 Published 2008 Journal Diabetes Section Body Doc Link PMC2570407 Disease Relevance 0.49 Pain Relevance 0
Under this experimental condition, the cells are homogeneous and express the surface markers CD90 and CD 29 and display adipogenic and osteogenic differentiation potential.
Gene_expression (express) of CD 29
3) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2919414 Disease Relevance 0.23 Pain Relevance 0.14
EGFP-negative cells present in the cultures displayed a clearly different morphology (data not shown) and presumably were rat fibroblast cells as they were not recognized by antibodies directed against human CD29 and CD73 (Figure 7, hCD29 vs. hCD73 dot plot on EGFP-negative cells).
Gene_expression (dot) of CD29 in fibroblast
4) Confidence 0.65 Published 2007 Journal BMC Biotechnol Section Body Doc Link PMC2225398 Disease Relevance 0.14 Pain Relevance 0.10
Flow cytometry analysis showed that the positive incidence of CD29, CD44, and CD90 were 81.56%, 88.77%, and 98.43%, respectively, while the positive incidence of CD34, CD45, CD71, and CD133 were 0.10%, 0.17%, 10.02%, and 1.56%, respectively (Figure 1C).
Gene_expression (incidence) of CD29
5) Confidence 0.65 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2905634 Disease Relevance 0 Pain Relevance 0
Proteins fibronectin 1 (FN1), integrin beta 1 (ITGB1) and platelet-derived growth factor receptor beta (PDGFRB) represent the top three 3 communication "hotpots" with the highest degree and traffic values in this network.
Gene_expression (represent) of integrin beta 1 in platelet
6) Confidence 0.62 Published 2010 Journal BMC Syst Biol Section Body Doc Link PMC2890499 Disease Relevance 0.20 Pain Relevance 0
ITGB1 and FN1 were identified among the top-3 high-traffic proteins.
Gene_expression (identified) of ITGB1
7) Confidence 0.62 Published 2010 Journal BMC Syst Biol Section Body Doc Link PMC2890499 Disease Relevance 0.56 Pain Relevance 0.04
Proteins fibronectin 1 (FN1), integrin beta 1 (ITGB1) and platelet-derived growth factor receptor beta (PDGFRB) represent the top three 3 communication "hotpots" with the highest degree and traffic values in this network.
Gene_expression (represent) of ITGB1 in platelet
8) Confidence 0.62 Published 2010 Journal BMC Syst Biol Section Body Doc Link PMC2890499 Disease Relevance 0.20 Pain Relevance 0
Cultivated MSCs were positive for CD29, CD44, and CD90, but negative for CD34, CD45, CD133, and CK12, with typical MSCs characteristics revealed by SEM.
Neg (negative) Gene_expression (negative) of CD29
9) Confidence 0.58 Published 2010 Journal Molecular Vision Section Abstract Doc Link PMC2905634 Disease Relevance 0.16 Pain Relevance 0
Many of these cells also express LFA-1 (CD11a/CD18), Mac-1 (CD11b/CD18), and VLA-4 (CD49d/CD29) on their surfaces.
Gene_expression (express) of CD29
10) Confidence 0.58 Published 2001 Journal Semin Dial Section Abstract Doc Link 11264784 Disease Relevance 0.81 Pain Relevance 0.12
Flow cytometry analysis revealed that the adherent fibroblast-like cells were consistently positive for CD29, CD44, CD105, and CD166, and were negative for CD14, CD34, and CD45.
Gene_expression (positive) of CD29 in fibroblast
11) Confidence 0.50 Published 2007 Journal J. Cell. Physiol. Section Abstract Doc Link 17171634 Disease Relevance 0.61 Pain Relevance 0.06
Adipose tissue-derived stem cells are understood to express surface markers of CD9, CD10, CD13, CD29, CD44, CD49d, CD49e, CD54, CD55, CD59, CD73, CD90, CD105, CD146, CD166, and STRO-1, and lack hematopoietic lineage markers CD11b, CD14, CD19, CD34, and CD45 [20,34,50-53].
Neg (lack) Gene_expression (express) of CD29 in stem cells associated with obesity
12) Confidence 0.29 Published 2010 Journal BMC Cell Biol Section Body Doc Link PMC2867791 Disease Relevance 0.17 Pain Relevance 0.06
The harvested cells were also analyzed for the expression of CD73, CD105, CD45, SSEA4, HLADR, HLAABC, CD14, CD31, CD44, CD29, and vWF markers, by flow cytometry.


Spec (analyzed) Gene_expression (expression) of CD29
13) Confidence 0.28 Published 2010 Journal Asian Journal of Transfusion Science Section Body Doc Link PMC2847339 Disease Relevance 0 Pain Relevance 0
MSCs strongly expressed surface proteins CD73, CD105, CD29, CD44, HLAABC, and weak-to-moderate expression of SSEA-4.
Gene_expression (expressed) of CD29
14) Confidence 0.28 Published 2010 Journal Asian Journal of Transfusion Science Section Body Doc Link PMC2847339 Disease Relevance 0.06 Pain Relevance 0
Confocal microscopy revealed that both BM-MPCs and T-MPCs expressed CD29, CD44, CD90, and CD105, but hematopoietic surface markers, including CD14, CD34, and CD45, were absent.
Gene_expression (expressed) of CD29
15) Confidence 0.28 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575631 Disease Relevance 0.14 Pain Relevance 0
IPFP cells at passage 2 expanded with and without FGF-2 stained strongly for CD13, CD44, CD90, and CD105 (markers for mesenchymal stem cells) and for CD29 (?
Gene_expression (stained) of CD29 in stem cells associated with peripheral arterial disease
16) Confidence 0.26 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575620 Disease Relevance 0.49 Pain Relevance 0
MSCs strongly expressed surface proteins CD73, CD105, CD29, CD44, HLAABC, and weak-to-moderate expression of SSEA-4.
Gene_expression (expression) of CD29
17) Confidence 0.25 Published 2010 Journal Asian Journal of Transfusion Science Section Body Doc Link PMC2847339 Disease Relevance 0.06 Pain Relevance 0
Classically, MSC are defined as being able to adhere to plastic, expressing CD29, CD73, CD44, CD90, CD105 antigens, and not expressing the hematopoietic cell markers CD34, CD45, and MHC class II antigen [35], although none of these markers appears to be exclusively expressed on MSC [36].
Neg (not) Gene_expression (expressing) of CD29 in hematopoietic cell
18) Confidence 0.25 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2956109 Disease Relevance 0 Pain Relevance 0
Classically, MSC are defined as being able to adhere to plastic, expressing CD29, CD73, CD44, CD90, CD105 antigens, and not expressing the hematopoietic cell markers CD34, CD45, and MHC class II antigen [35], although none of these markers appears to be exclusively expressed on MSC [36].
Neg (not) Gene_expression (expressing) of CD29 in hematopoietic cell
19) Confidence 0.25 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2956109 Disease Relevance 0 Pain Relevance 0
The microarray gene expression analysis of these cells indicates that the cells are negative for the hematopoietic markers CD34, CD49c, CD49d, CD62e, CD62p, CD106, CD117, CD133, CD235a, HLA-DRB4, HLA-DRB4 and HAS1, and positive for the mesenchymal markers CD13, CD29, CD44, CD49a/b, CD49e, CD73, CD105 and vimentin [18], supporting their USSCs/MSC origin.
Gene_expression (expression) of CD29
20) Confidence 0.25 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2956109 Disease Relevance 0 Pain Relevance 0

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