INT94454

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Context Info
Confidence 0.72
First Reported 2001
Last Reported 2010
Negated 8
Speculated 1
Reported most in Abstract
Documents 73
Total Number 82
Disease Relevance 63.94
Pain Relevance 10.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (CD68) plasma membrane (CD68)
Anatomy Link Frequency
macrophages 19
microglia 7
adipose tissue 6
fat 3
monocyte 2
CD68 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 626 99.80 Very High Very High Very High
Arthritis 319 99.64 Very High Very High Very High
Inflammation 838 99.56 Very High Very High Very High
cytokine 315 99.20 Very High Very High Very High
tolerance 66 98.20 Very High Very High Very High
metalloproteinase 176 97.20 Very High Very High Very High
drug abuse 8 95.72 Very High Very High Very High
Substantia nigra 539 94.88 High High
Infliximab 35 94.24 High High
Inflammatory response 36 93.92 High High
Disease Link Frequency Relevance Heat
Obesity 1769 99.98 Very High Very High Very High
Cancer 370 99.86 Very High Very High Very High
Rheumatoid Arthritis 706 99.80 Very High Very High Very High
Histiocytic Sarcoma 66 99.70 Very High Very High Very High
Seronegative Spondarthritis 273 99.64 Very High Very High Very High
Death 577 99.60 Very High Very High Very High
Infection 126 99.60 Very High Very High Very High
INFLAMMATION 908 99.56 Very High Very High Very High
Disease 665 99.54 Very High Very High Very High
Insulin Resistance 132 99.50 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunohistochemically, most tumor cells expressed vimentin, alpha-1 anti-chymotrypsin, alpha-1 antitrypsin and CD68.
Gene_expression (expressed) of CD68 associated with cancer
1) Confidence 0.72 Published 2007 Journal Histol. Histopathol. Section Abstract Doc Link 17701913 Disease Relevance 0.87 Pain Relevance 0.09
Microscopic examination revealed an inflammatory lesion composed of plasma cells, scattered lymphocytes and numerous large histocytic cells, which exhibited emperi polesis and were CD1 a negative, but positive for CD68 and S100.
Gene_expression (positive) of CD68 in lymphocytes associated with inflammation
2) Confidence 0.68 Published 2002 Journal Brain Pathol. Section Abstract Doc Link 12408240 Disease Relevance 0.88 Pain Relevance 0.18
The granular cells of the current case were positive for neuron-specific enolase (NSE), S-100 protein, GFAP, vimentin, CD 68, lysozyme, and alpha-1-antitrypsin.
Gene_expression (positive) of CD 68 in neuron
3) Confidence 0.65 Published 2008 Journal Neuropathology Section Abstract Doc Link 18466222 Disease Relevance 0.89 Pain Relevance 0.08
The dilutions used were: CD3 1:100; CD4 1:25; CD8 1:100; CD68 1:50; EG2 1:200; NE 1:200; AA1 1:100; CD20 1:400.
Gene_expression (1:25) of CD68
4) Confidence 0.65 Published 2005 Journal Respir Res Section Body Doc Link PMC1140754 Disease Relevance 0.08 Pain Relevance 0
In the present study, we observed relationships between high adiposity, insulin resistance, and the adipose tissue expression of macrophage cell surface receptor CD68.
Gene_expression (expression) of CD68 in macrophage associated with obesity and insulin resistance
5) Confidence 0.65 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC3010654 Disease Relevance 1.62 Pain Relevance 0.12
In addition, adipose tissue CD68 expressions were related to the expressions of TNF-?
Gene_expression (expressions) of CD68 in adipose tissue associated with obesity
6) Confidence 0.65 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC3010654 Disease Relevance 1.64 Pain Relevance 0.14
In summary, the present study demonstrated relationships between obesity, adipose tissue inflammation reflected by increased adipose tissue expressions of CD68 and TNF-?
Gene_expression (expressions) of CD68 in adipose tissue associated with inflammation and obesity
7) Confidence 0.65 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC3010654 Disease Relevance 2.16 Pain Relevance 0.31
Our data demonstrate that obesity is linked to increased adipose tissue expressions of CD68 and TNF-?
Gene_expression (expressions) of CD68 in adipose tissue associated with obesity
8) Confidence 0.65 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC3010654 Disease Relevance 1.62 Pain Relevance 0.13
However, compared to cachectic and normal-weight COPD patients, those with obesity had median values of adipose tissue expressions of CD68 higher by 240% and 89%, and of TNF-?
Gene_expression (expressions) of CD68 in adipose tissue associated with pulmonary disease and obesity
9) Confidence 0.65 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC3010654 Disease Relevance 1.73 Pain Relevance 0.26
Immunohistochemical staining reveals that macrophages in tenosynovial tissues express CD13, CD14, CD33, HLA-DR, and CD68 antigens on their surfaces and express interleukin (IL)-1 beta, tumor necrosis factor (TNF)-alpha, and IL-6.
Gene_expression (express) of CD68 in macrophages associated with necrosis and cancer
10) Confidence 0.64 Published 2001 Journal Semin Dial Section Abstract Doc Link 11264784 Disease Relevance 0.84 Pain Relevance 0.12
However, some cells expressed the macrophage marker CD68.
Gene_expression (expressed) of CD68 in macrophage
11) Confidence 0.62 Published 2006 Journal J. Oral Pathol. Med. Section Body Doc Link 16430741 Disease Relevance 0.08 Pain Relevance 0
Immunohistochemistry results were positive for CD34 and CD68.
Gene_expression (positive) of CD68
12) Confidence 0.62 Published 2006 Journal Skinmed Section Abstract Doc Link 16957440 Disease Relevance 0.38 Pain Relevance 0.16
However, YKL-40 may only be produced by a subgroup of macrophages (CD14+ and CD16+) in adipose tissue, as seen in other diseases (1), in contrast with CD68, which is produced by all monocytes and macrophages.
Gene_expression (produced) of CD68 in macrophages associated with obesity and disease
13) Confidence 0.60 Published 2008 Journal Diabetes Section Body Doc Link PMC2570404 Disease Relevance 1.12 Pain Relevance 0.04
Given that YKL-40 is produced by macrophages, it is surprising that CD68 mRNA expression in adipose tissue did not correlate with plasma YKL-40.
Gene_expression (expression) of CD68 mRNA in plasma associated with obesity
14) Confidence 0.60 Published 2008 Journal Diabetes Section Body Doc Link PMC2570404 Disease Relevance 1.11 Pain Relevance 0.04
His skin specimen revealed infiltration in the dermis and subcutaneous fat tissue by leukemic cells that were positive for the leukocyte common antigen (LCA, CD45), CD15, CD33, CD68, and HLA-DR.
Gene_expression (positive) of CD68 in fat
15) Confidence 0.58 Published 2001 Journal Leuk. Lymphoma Section Abstract Doc Link 11426568 Disease Relevance 0.77 Pain Relevance 0.08
CD68 was diffusely positive in both the histiocytes and spindle cell component in all cases.
Gene_expression (positive) of CD68 in histiocytes
16) Confidence 0.58 Published 2005 Journal Int. J. Surg. Pathol. Section Abstract Doc Link 15864383 Disease Relevance 1.34 Pain Relevance 0.33
The spindle cells were diffuse positive for VIM, ACT, CD68 and negative for desmin, MNF116, SyN, S100, HMB45, and CD117.
Neg (negative) Gene_expression (positive) of CD68 in spindle cells
17) Confidence 0.58 Published 2007 Journal Rom J Morphol Embryol Section Abstract Doc Link 18060198 Disease Relevance 0.85 Pain Relevance 0.21
OPN was localized in two distinct cell types, i.e., fibroblast-like cells negative for CD68 and tartrate-resistant acid phosphatase (TRAP) and multinucleated macrophages positive for CD68 and TRAP.
Neg (negative) Gene_expression (negative) of CD68 in macrophages
18) Confidence 0.58 Published 2001 Journal Virchows Arch. Section Abstract Doc Link 11469694 Disease Relevance 0.38 Pain Relevance 0.13
Fragments of the tumor were fixed in 10% formaldehyde, included in paraffin, and the sections were stained with HE, VG and immunohistochemically with vimentin (VIM), MNF116, SyN, smooth muscle actin (ACT), desmin, CD68, S100, HMB45, and CD117.
Gene_expression (stained) of CD68 in smooth muscle associated with cancer
19) Confidence 0.58 Published 2007 Journal Rom J Morphol Embryol Section Abstract Doc Link 18060198 Disease Relevance 0.93 Pain Relevance 0.23
The OGCs expressed bone-osteoclast markers (MMP9, TRAP, cathepsin K) and a histiocyte marker (CD68), but not an MHC class II antigen, HLA-DR.
Neg (not) Gene_expression (expressed) of CD68 in histiocyte
20) Confidence 0.57 Published 2010 Journal Diagn Pathol Section Abstract Doc Link PMC2936386 Disease Relevance 0.77 Pain Relevance 0.08

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