INT94463

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Context Info
Confidence 0.36
First Reported 2000
Last Reported 2010
Negated 2
Speculated 3
Reported most in Body
Documents 10
Total Number 14
Disease Relevance 5.17
Pain Relevance 2.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Hand1) nucleoplasm (Hand1) enzyme binding (Hand1)
DNA binding (Hand1) cytoplasm (Hand1) nucleolus (Hand1)
Anatomy Link Frequency
macrophages 2
Peyer's patch 2
T-cell 2
neutrophils 2
Hand1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 245 100.00 Very High Very High Very High
Inflammation 103 100.00 Very High Very High Very High
qutenza 10 100.00 Very High Very High Very High
opioid receptor 1 96.56 Very High Very High Very High
Opioid 2 95.64 Very High Very High Very High
antagonist 3 95.28 Very High Very High Very High
narcan 7 94.40 High High
Enkephalin 3 86.52 High High
chemokine 36 77.24 Quite High
Arthritis 15 59.76 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 103 100.00 Very High Very High Very High
Cystitis 70 99.20 Very High Very High Very High
Colitis 71 98.40 Very High Very High Very High
Sprains And Strains 114 97.36 Very High Very High Very High
Targeted Disruption 53 96.32 Very High Very High Very High
Infection 154 94.76 High High
Malignant Neoplastic Disease 2 92.60 High High
Melioidosis 57 92.44 High High
Hypersensitivity 36 90.36 High High
Mycobacterial Infection 2 89.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We present evidence that these effects could be mediated by the modulation of Th1/Th2 cytokine production.
Regulation (modulation) of Gene_expression (production) of Th1 associated with cytokine
1) Confidence 0.36 Published 2000 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 11268404 Disease Relevance 0.06 Pain Relevance 0.67
However, the reduced OVA-specific Th1 response in IFN-?
Regulation (specific) of Gene_expression (response) of Th1
2) Confidence 0.27 Published 2005 Journal Respir Res Section Body Doc Link PMC555575 Disease Relevance 0.31 Pain Relevance 0.08
Allergen specific Th1 response as a result of CpG-ODN vaccination is partly impaired in the absence of IFN-?
Regulation (Allergen) of Gene_expression (response) of Th1
3) Confidence 0.27 Published 2005 Journal Respir Res Section Body Doc Link PMC555575 Disease Relevance 0.06 Pain Relevance 0
Interestingly, however, infectious reagents such as LPS or the TH1 cytokine INF-?
Regulation (infectious) of Gene_expression (reagents) of TH1 associated with cytokine
4) Confidence 0.24 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2817648 Disease Relevance 0.15 Pain Relevance 0.12
Since the underlying mechanisms by which this and other immunomodulatory effects occur have not been established, this report explores the in vitro modulation of Th1 and Th2 cytokine expression by these peptides.
Regulation (modulation) of Gene_expression (expression) of Th1 associated with cytokine
5) Confidence 0.23 Published 2005 Journal Neuroimmunomodulation Section Abstract Doc Link 16557034 Disease Relevance 0.09 Pain Relevance 0.33
We investigated the effects of red pepper (Capsicum annuum Lin.) extracts (capsicum extract) and its main pungent capsaicin on T helper 1 (Th1) and 2 (Th2) cytokine production in cultured murine Peyer's patch (PP) cells in vitro and ex vivo.
Spec (investigated) Regulation (effects) of Gene_expression (production) of Th1 in Peyer's patch associated with qutenza and cytokine
6) Confidence 0.21 Published 2007 Journal Life Sci. Section Abstract Doc Link 17306834 Disease Relevance 0 Pain Relevance 0.37
As with these innate immunity cells, neutrophils are compartmentalized in the MLN and tightly regulated to differentially express CXCL9 and CXCL11, CXCR3 and Th1-associated cytokines during Mycobacteria-mediated colitis.
Regulation (regulated) of Gene_expression (express) of Th1-associated in neutrophils associated with colitis and cytokine
7) Confidence 0.19 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2443107 Disease Relevance 0.82 Pain Relevance 0.05
It is possible that macrophages, NK, and CD8 cells are responsible for the increased levels of TH1 cytokines observed in this study, which would agree with other murine models [21, 30, 38, 39].
Regulation (responsible) of Gene_expression (levels) of TH1 in macrophages associated with cytokine
8) Confidence 0.17 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2852613 Disease Relevance 0.85 Pain Relevance 0.05
However, we found no significant differences in the levels of the Th1 cytokines IL-12 and IFN-?
Neg (no) Regulation (differences) of Gene_expression (levels) of Th1 associated with cytokine
9) Confidence 0.15 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2930856 Disease Relevance 1.11 Pain Relevance 0.26
Also, a stronger inflammatory TH1 response, represented by IL-12p40, IFN?
Regulation (stronger) of Gene_expression (response) of TH1 associated with inflammation
10) Confidence 0.15 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Abstract Doc Link PMC2852613 Disease Relevance 0.93 Pain Relevance 0.05
To investigate local and peripheral changes in Th1 and inflammatory cytokine expression during CYP-induced cystitis, the levels of IFN-?
Spec (investigate) Regulation (changes) of Gene_expression (expression) of Th1 associated with inflammation, cystitis and cytokine
11) Confidence 0.14 Published 2008 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC2583981 Disease Relevance 0.43 Pain Relevance 0.17
On further extrapolation of this study, the chloroform, n-butanol, and water fractions were investigated for flow cytometric studies on Th1 and Th2 cytokines, wherein, only the chloroform fraction (PLC) showed marked immunosuppressive and anti-inflammatory activity, as evidenced from the downregulation of T-cell surface markers (CD8+/CD4+) and intracellular Th1 (IL-2 and IFN-?)
Spec (investigated) Regulation (studies) of Gene_expression (cytokines) of Th1 in T-cell associated with inflammation and cytokine
12) Confidence 0.13 Published 2010 Journal Indian Journal of Pharmacology Section Body Doc Link PMC2885635 Disease Relevance 0.16 Pain Relevance 0.14
No significant change in the mean levels of TH1 cytokine (IL-2) was seen in any of their patient groups.
Neg (No) Regulation (change) of Gene_expression (cytokine) of TH1 associated with cytokine
13) Confidence 0.11 Published 2010 Journal Asian Journal of Transfusion Science Section Body Doc Link PMC2937301 Disease Relevance 0.09 Pain Relevance 0.29
We studied the effect of leukodepletion on the production of cytokines of Th1 (IFN-?)
Regulation (effect) of Gene_expression (production) of Th1 associated with cytokine
14) Confidence 0.07 Published 2010 Journal Asian Journal of Transfusion Science Section Body Doc Link PMC2937301 Disease Relevance 0.09 Pain Relevance 0.12

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