INT94465

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Context Info
Confidence 0.38
First Reported 2000
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 43
Total Number 44
Disease Relevance 29.76
Pain Relevance 10.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Hand1) nucleoplasm (Hand1) enzyme binding (Hand1)
DNA binding (Hand1) cytoplasm (Hand1) nucleolus (Hand1)
Anatomy Link Frequency
Th1 cells 10
T-cell 6
spleen 5
macrophages 4
microglia 4
Hand1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 1008 100.00 Very High Very High Very High
chemokine 174 100.00 Very High Very High Very High
Inflammation 887 99.98 Very High Very High Very High
rheumatoid arthritis 123 99.50 Very High Very High Very High
narcan 7 98.72 Very High Very High Very High
Endocannabinoid 16 98.40 Very High Very High Very High
interstitial cystitis 41 96.56 Very High Very High Very High
tolerance 33 93.96 High High
Arthritis 224 93.40 High High
Central nervous system 46 93.32 High High
Disease Link Frequency Relevance Heat
Colitis 17 100.00 Very High Very High Very High
INFLAMMATION 951 99.98 Very High Very High Very High
Cryptococcus Infection 90 99.92 Very High Very High Very High
Arthropathy 10 99.88 Very High Very High Very High
Infection 660 99.60 Very High Very High Very High
Rheumatoid Arthritis 132 99.50 Very High Very High Very High
Cystitis 70 99.36 Very High Very High Very High
Graft Vs Host Disease 1 99.36 Very High Very High Very High
Hypersensitivity 143 98.56 Very High Very High Very High
Sprains And Strains 452 98.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover in C57BL/6 mice, naloxone treatment was able to accelerate skin-graft rejection, a Th1-mediated phenomenon, by increasing Th1 cytokine production.
Positive_regulation (increasing) of Gene_expression (production) of Th1 in skin associated with narcan, graft vs host disease and cytokine
1) Confidence 0.38 Published 2000 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 11268404 Disease Relevance 0.10 Pain Relevance 0.85
We have identified, using serial analysis of gene expression, transcripts that are overexpressed in regulatory T cells compared with Th1 and Th2 clones.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of Th1 in regulatory T cells
2) Confidence 0.33 Published 2002 Journal J. Immunol. Section Abstract Doc Link 11801640 Disease Relevance 0.09 Pain Relevance 0.11
Furthermore, evidence suggests that endocannabinoids have immunosuppressant and anti-inflammatory properties, they downregulate the production of T helper 1 (Th1) cytokines, enhancing the production of T helper 2 (Th2) cytokines, since a polarization of T cell response towards a Th2 phenotype has been associated with therapeutic benefit in MS, while a shift towards Th1 has been associated with disease progression (Matsuda et al 1990; Hemmer 2002).
Positive_regulation (cytokines) of Gene_expression (production) of Th1 in T cell associated with endocannabinoid, multiple sclerosis, inflammation, disease progression and cytokine
3) Confidence 0.33 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2626929 Disease Relevance 0.84 Pain Relevance 0.80
Our results indicate that induction of Th1 response by therapy with CpG-ODN is partially dependent on IFN-?
Positive_regulation (induction) of Gene_expression (response) of Th1
4) Confidence 0.30 Published 2005 Journal Respir Res Section Body Doc Link PMC555575 Disease Relevance 0.78 Pain Relevance 0.22
production after IM vaccination is consistent with the heightened Th1-like response indicated by the reduced IgG1/IgG2a ratio in the IM groups, since IFN-?
Positive_regulation (since) of Gene_expression (consistent) of Th1
5) Confidence 0.28 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2651574 Disease Relevance 0.16 Pain Relevance 0
Serum levels of these CXCR3 ligands and local T helper type 1 (Th1) cytokines were also increased.
Positive_regulation (increased) of Gene_expression (levels) of Th1 associated with cytokine
6) Confidence 0.27 Published 2008 Journal J Immune Based Ther Vaccines Section Abstract Doc Link PMC2583981 Disease Relevance 0.58 Pain Relevance 0.34
The homing of adoptively transferred Th1 cells was performed as previously described (44).
Positive_regulation (transferred) of Gene_expression (transferred) of Th1 in Th1 cells
7) Confidence 0.25 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2525589 Disease Relevance 0.58 Pain Relevance 0.05
has also been demonstrated, based on the induction of inducible nitric oxide synthase (14) and of IL-12 in antigen-presenting cells, in turn increasing the IL-10 synthesis of Th1 cells (15).
Positive_regulation (increasing) of Gene_expression (synthesis) of Th1 in Th1 cells
8) Confidence 0.25 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2525589 Disease Relevance 0.74 Pain Relevance 0.34
A mouse line of mutated gp130 in which the SHP-2/SOCS3-binding site was disrupted developed a RA-like joint disease with increased production of Th1-type cytokines and immunoglobulins of the IgG2a and IgG2b classes [78].
Positive_regulation (increased) of Gene_expression (production) of Th1-type in joint associated with rheumatoid arthritis, arthropathy and cytokine
9) Confidence 0.24 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 1.36 Pain Relevance 0.52
OVA-specific 6-d-old Th1 cells ectopically overexpressing twist1 and control Th1 cells were transferred intravenously into naive BALB/c mice.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of Th1 in Th1 cells
10) Confidence 0.23 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2525589 Disease Relevance 0.52 Pain Relevance 0.16
S7 displays in vivo migration capacity of twist1 overexpressing and control Th1 cells to remaining organs despite footpad and draining lymph nodes in the DTH response.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of Th1 in Th1 cells associated with hypersensitivity
11) Confidence 0.23 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2525589 Disease Relevance 0.45 Pain Relevance 0.26
, but it significantly suppressed IL-4 production by spleen cells, resulting in an increased Th1/Th2 response.
Positive_regulation (increased) of Gene_expression (response) of Th1 in spleen
12) Confidence 0.21 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206348 Disease Relevance 1.06 Pain Relevance 0.45
In this study, we found that OVA-induced airway inflammation was inhibited after Ag85B vaccine treatment; meanwhile, Th1 cytokine production was increased while the Th2 cytokine production was decreased in the lung and spleen.
Positive_regulation (increased) of Gene_expression (production) of Th1 in spleen associated with inflammation and cytokine
13) Confidence 0.21 Published 2009 Journal Respir Res Section Body Doc Link PMC2713210 Disease Relevance 0.67 Pain Relevance 0.40
-mediated (Th1) response production necessary for microbial defense.
Positive_regulation (necessary) of Gene_expression (production) of Th1
14) Confidence 0.21 Published 2010 Journal Respir Res Section Body Doc Link PMC2841591 Disease Relevance 1.35 Pain Relevance 0.15
We also observed that T cells produce higher amounts of Th1 cytokines such as IFN-?
Positive_regulation (amounts) of Gene_expression (produce) of Th1 in T cells associated with cytokine
15) Confidence 0.21 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 0.50 Pain Relevance 0.08
In mice, adoptive transfer of Th1 clones increased cell infiltration and caused reversible HP (4).
Positive_regulation (transfer) of Gene_expression (transfer) of Th1 associated with hypersensitivity pneumonitis
16) Confidence 0.20 Published 2010 Journal Immune Network Section Body Doc Link PMC2837154 Disease Relevance 1.11 Pain Relevance 0.19
In mice, adoptive transfer of Th1 clones increased cell infiltration and caused reversible HP (4).
Positive_regulation (increased) of Gene_expression (transfer) of Th1 associated with hypersensitivity pneumonitis
17) Confidence 0.20 Published 2010 Journal Immune Network Section Body Doc Link PMC2837154 Disease Relevance 1.11 Pain Relevance 0.19
plus CD40L pre-treatment of microglia resulted in markedly enhanced levels of the Th1-promoting cytokines IL-6, TNF-?
Positive_regulation (enhanced) of Gene_expression (levels) of Th1 in microglia associated with cytokine
18) Confidence 0.20 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1298325 Disease Relevance 0.13 Pain Relevance 0.30
plus CD40L pre-treatment of microglia resulted in markedly enhanced levels of the Th1-promoting cytokines IL-6, TNF-?
Positive_regulation (resulted) of Gene_expression (levels) of Th1 in microglia associated with cytokine
19) Confidence 0.20 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1298325 Disease Relevance 0.13 Pain Relevance 0.31
in a Th1 model of colitis and upregulate IFN-?
Positive_regulation (upregulate) of Gene_expression (model) of Th1 associated with colitis
20) Confidence 0.19 Published 2010 Journal PPAR Research Section Body Doc Link PMC2796461 Disease Relevance 0.80 Pain Relevance 0.29

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