INT94466

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Context Info
Confidence 0.28
First Reported 2000
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 14
Total Number 15
Disease Relevance 7.97
Pain Relevance 4.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Hand2) nucleus (Hand2) DNA binding (Hand2)
protein complex (Hand2) transcription factor binding (Hand2)
Anatomy Link Frequency
T cells 8
Th2 cell 2
lung 2
goblet cell 2
Hand2 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 499 100.00 Very High Very High Very High
Inflammation 585 99.90 Very High Very High Very High
Catecholamine 6 99.46 Very High Very High Very High
antagonist 145 99.38 Very High Very High Very High
opioid receptor 1 96.56 Very High Very High Very High
Opioid 2 95.64 Very High Very High Very High
narcan 7 94.40 High High
chemokine 96 90.00 High High
Enkephalin 7 86.52 High High
Inflammatory response 29 74.24 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 611 99.90 Very High Very High Very High
Asthma 1078 99.84 Very High Very High Very High
Adhesions 43 99.80 Very High Very High Very High
Hyperplasia 48 99.16 Very High Very High Very High
Respiratory Syncytial Virus 5 92.60 High High
Stress 145 92.24 High High
Pneumonia 31 90.44 High High
Hypersensitivity 109 90.36 High High
Eosinophilia 59 90.00 High High
Aging 22 89.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We present evidence that these effects could be mediated by the modulation of Th1/Th2 cytokine production.
Regulation (modulation) of Gene_expression (production) of Th2 associated with cytokine
1) Confidence 0.28 Published 2000 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 11268404 Disease Relevance 0.06 Pain Relevance 0.67
These results suggest that sTNFR treatment can suppress the airway inflammation via regulation of Th2 cytokine production and adhesion molecule expression in bronchial asthma.
Regulation (regulation) of Gene_expression (production) of Th2 associated with asthma, inflammation, adhesions and cytokine
2) Confidence 0.26 Published 2009 Journal Yonsei Medical Journal Section Body Doc Link PMC2730622 Disease Relevance 1.14 Pain Relevance 0.26
Since the underlying mechanisms by which this and other immunomodulatory effects occur have not been established, this report explores the in vitro modulation of Th1 and Th2 cytokine expression by these peptides.
Regulation (modulation) of Gene_expression (expression) of Th2 associated with cytokine
3) Confidence 0.18 Published 2005 Journal Neuroimmunomodulation Section Abstract Doc Link 16557034 Disease Relevance 0.09 Pain Relevance 0.33
Neither IL-4, in Th2 polarization, nor IL-6, TGF-?
Neg (nor) Regulation (nor) of Gene_expression (polarization) of Th2
4) Confidence 0.16 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2525589 Disease Relevance 0.11 Pain Relevance 0.06
On further extrapolation of this study, the chloroform, n-butanol, and water fractions were investigated for flow cytometric studies on Th1 and Th2 cytokines, wherein, only the chloroform fraction (PLC) showed marked immunosuppressive and anti-inflammatory activity, as evidenced from the downregulation of T-cell surface markers (CD8+/CD4+) and intracellular Th1 (IL-2 and IFN-?)
Spec (investigated) Regulation (studies) of Gene_expression (cytokines) of Th2 in T-cell associated with inflammation and cytokine
5) Confidence 0.15 Published 2010 Journal Indian Journal of Pharmacology Section Body Doc Link PMC2885635 Disease Relevance 0.16 Pain Relevance 0.14
Effects of nano particles on local expression of Th2 cytokines in the presence of antigen
Regulation (Effects) of Gene_expression (expression) of Th2 associated with cytokine
6) Confidence 0.15 Published 2005 Journal Respir Res Section Body Doc Link PMC1242256 Disease Relevance 0.17 Pain Relevance 0.14
We examined the ability of H4R antagonists to therapeutically modify the effects of Th2 cytokine production such as goblet cell hyperplasia (GCH), and collagen deposition in a sub-chronic model of asthma.
Regulation (effects) of Gene_expression (production) of Th2 in goblet cell associated with asthma, antagonist, hyperplasia and cytokine
7) Confidence 0.13 Published 2010 Journal Respir Res Section Abstract Doc Link PMC2914735 Disease Relevance 0.95 Pain Relevance 0.42
These results suggest that sTNFR treatment can suppress the airway inflammation via regulation of Th2 cytokine production and adhesion molecule expression in bronchial asthma.



Regulation (regulation) of Gene_expression (production) of Th2 associated with asthma, inflammation, adhesions and cytokine
8) Confidence 0.12 Published 2009 Journal Yonsei Medical Journal Section Abstract Doc Link PMC2730622 Disease Relevance 1.01 Pain Relevance 0.32
To explore the role of local expression of Th2 cytokines in the effects of nano particles on antigen-related airway inflammation, we quantitated protein levels of IL-5, IL-4, and IL-13 in the lung tissue supernatants (Table 3).
Regulation (role) of Gene_expression (expression) of Th2 in lung associated with inflammation and cytokine
9) Confidence 0.11 Published 2005 Journal Respir Res Section Body Doc Link PMC1242256 Disease Relevance 0.17 Pain Relevance 0.15
In animal studies, PDE4 inhibitors inhibit antigen-mediated T cell proliferation and skew the T cell cytokine profile toward a Th2 phenotype by downregulating the expression or production of Th1 cytokines without affecting Th2 cytokine expression [58,59].
Neg (without) Regulation (affecting) of Gene_expression (expression) of Th2 in T cell associated with cytokine
10) Confidence 0.08 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.25 Pain Relevance 0.47
Modulators of the synthesis or action of key proinflammatory Th2 cell cytokines
Regulation (Modulators) of Gene_expression (synthesis) of Th2 in Th2 cell associated with cytokine
11) Confidence 0.08 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 1.06 Pain Relevance 0.54
Other modulators of the Th1/Th2 balance in asthma
Regulation (modulators) of Gene_expression (balance) of Th2 associated with asthma
12) Confidence 0.08 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 1.42 Pain Relevance 0.20
Glucocorticoids and catecholamines mediate a Th2 shift by up-regulating Th2 cytokine production and also by suppressing APCs and Th1 cytokine synthesis [34, 35].
Regulation (regulating) of Gene_expression (production) of Th2 associated with catecholamine and cytokine
13) Confidence 0.05 Published 2009 Journal J Ocul Biol Dis Infor Section Body Doc Link PMC2723676 Disease Relevance 1.26 Pain Relevance 0.54
In human CD4 T cells, inhibition of p38 MAPK by SB203580 or by a dominant-negative mutant of p38 MAPK reduced the expression of IL-4, IL-5, and IL-13 in response to CD3 and/or CD28 stimulation [60,61], indicating that the p38 MAPK pathway has a critical role in the regulation of Th2 cytokine expression in primary human T cells (Fig. 2).
Regulation (role) of Gene_expression (expression) of Th2 in T cells associated with cytokine
14) Confidence 0.03 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526596 Disease Relevance 0.06 Pain Relevance 0.12
In human CD4 T cells, inhibition of p38 MAPK by SB203580 or by a dominant-negative mutant of p38 MAPK reduced the expression of IL-4, IL-5, and IL-13 in response to CD3 and/or CD28 stimulation [60,61], indicating that the p38 MAPK pathway has a critical role in the regulation of Th2 cytokine expression in primary human T cells (Fig. 2).
Regulation (regulation) of Gene_expression (expression) of Th2 in T cells associated with cytokine
15) Confidence 0.03 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526596 Disease Relevance 0.06 Pain Relevance 0.12

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