INT94467

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Context Info
Confidence 0.58
First Reported 2000
Last Reported 2011
Negated 1
Speculated 3
Reported most in Body
Documents 71
Total Number 78
Disease Relevance 59.00
Pain Relevance 16.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Hand1) nucleoplasm (Hand1) enzyme binding (Hand1)
DNA binding (Hand1) cytoplasm (Hand1) nucleolus (Hand1)
Anatomy Link Frequency
Th1 cells 7
T cell 6
lung 5
macrophages 2
dendritic cells 1
Hand1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 1220 100.00 Very High Very High Very High
Opioid 4 100.00 Very High Very High Very High
narcan 18 99.98 Very High Very High Very High
Inflammatory response 71 99.96 Very High Very High Very High
Multiple sclerosis 87 99.80 Very High Very High Very High
Inflammation 1030 99.64 Very High Very High Very High
psoriasis 64 99.12 Very High Very High Very High
chemokine 312 98.98 Very High Very High Very High
Arthritis 323 98.76 Very High Very High Very High
Catecholamine 2 96.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Apoptosis 88 100.00 Very High Very High Very High
Infection 1370 99.98 Very High Very High Very High
INFLAMMATION 1082 99.96 Very High Very High Very High
Death 53 99.92 Very High Very High Very High
Multiple Sclerosis 137 99.80 Very High Very High Very High
Lung Cancer 26 99.74 Very High Very High Very High
Embryo Loss 9 99.64 Very High Very High Very High
Mycobacterial Infection 745 99.52 Very High Very High Very High
Lewis Lung Carcinoma 409 99.50 Very High Very High Very High
Cancer 639 99.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These hormones can modulate immune responses via the induction of Th1 immunity.
Positive_regulation (induction) of Th1
1) Confidence 0.58 Published 2007 Journal Allergol Int Section Abstract Doc Link 17259807 Disease Relevance 0.95 Pain Relevance 0.31
These results indicate that naloxone increases Th1 and decreases Th2 cytokine production.
Positive_regulation (increases) of Th1 associated with narcan and cytokine
2) Confidence 0.56 Published 2000 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 11268404 Disease Relevance 0.09 Pain Relevance 0.84
This would represent a counterbalance by IL-10 expression, a Th2 cytokine, as a consequence of Th1 enhancement.
Positive_regulation (enhancement) of Th1 associated with cytokine
3) Confidence 0.41 Published 2008 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2647907 Disease Relevance 0.81 Pain Relevance 0.28
Although the 2 groups of mice exhibited no quantitative or proportional differences in splenic lymphocyte populations, the apoE -/- mice showed enhanced antigen-specific proliferation of T cells of spleen, which is related to modified macrophage function, upregulation of Th1 and downregulation of Th2-autoreactive responses to P0 peptide.
Positive_regulation (upregulation) of Th1 in spleen
4) Confidence 0.38 Published 2004 Journal J. Neuropathol. Exp. Neurol. Section Abstract Doc Link 14989598 Disease Relevance 1.08 Pain Relevance 0.67
Microarray analysis, followed by real time RT-PCR validation, revealed that Th1 and Th17 cytokine-, opioid peptide-, and anti-apoptosis-related genes were up-regulated upon treatment with EA.
Positive_regulation (up-regulated) of Th1 associated with apoptosis, opioid and cytokine
5) Confidence 0.35 Published 2010 Journal Cell. Mol. Neurobiol. Section Abstract Doc Link 20041291 Disease Relevance 0.28 Pain Relevance 0.23
The cytokine profiles for mutated peptide vaccinated mice indicated a peptide-specific response with elevated Th1 (TNF-?
Positive_regulation (elevated) of Th1 associated with cytokine
6) Confidence 0.35 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2270279 Disease Relevance 0.24 Pain Relevance 0.29
In addition, naloxone induced a shift from Th1 cytokine toward Th2 cytokine balance.
Positive_regulation (induced) of Th1 associated with narcan and cytokine
7) Confidence 0.32 Published 2008 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 19033824 Disease Relevance 0.81 Pain Relevance 0.85
On day 21, anti-OVA IgG2a and interferon (IFN)-gamma as indicators of Th1 responses and anti-OVA IgG1 and interleukin (IL)-10 as those of Th2 responses were measured.
Positive_regulation (indicators) of Th1
8) Confidence 0.32 Published 2005 Journal Int J Immunopathol Pharmacol Section Abstract Doc Link 15698518 Disease Relevance 0.34 Pain Relevance 0.44
levels were comparable between the two groups of mice, indicating that PPD-specific T cells had differentiated into Th1 by the sensitization.
Positive_regulation (differentiated) of Th1 in T cells
9) Confidence 0.31 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2721999 Disease Relevance 0.88 Pain Relevance 0
Intriguingly, vaults containing another protein, GL, but not empty vaults, also significantly induced the maturation of BMDC by causing secretion of IL-12p70, IL-10 and CXCL10 but not IL-4 (data not shown) suggesting that vaults containing proteins favor induction of Th1 immune responses.
Positive_regulation (induction) of Th1
10) Confidence 0.31 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2671841 Disease Relevance 0.33 Pain Relevance 0.40
Therefore, a strategy of upregulating the Th1 immune response or downregulating the Th2 immune response may be valuable in the prophylaxis and management of bronchial asthma [7,8].
Positive_regulation (upregulating) of Th1 associated with asthma
11) Confidence 0.29 Published 2009 Journal Respir Res Section Body Doc Link PMC2713210 Disease Relevance 1.10 Pain Relevance 0.27
This nature of SOCS1-deficient DCs can be applied to anti-tumor immunity, because strong Th1 induction is believed to be important for DC-mediated vaccination.
Positive_regulation (induction) of Th1 associated with cancer
12) Confidence 0.29 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 0.49 Pain Relevance 0.08
Furthermore, evidence suggests that endocannabinoids have immunosuppressant and anti-inflammatory properties, they downregulate the production of T helper 1 (Th1) cytokines, enhancing the production of T helper 2 (Th2) cytokines, since a polarization of T cell response towards a Th2 phenotype has been associated with therapeutic benefit in MS, while a shift towards Th1 has been associated with disease progression (Matsuda et al 1990; Hemmer 2002).
Positive_regulation (shift) of Th1 in T cell associated with endocannabinoid, multiple sclerosis, inflammation, disease progression and cytokine
13) Confidence 0.28 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2626929 Disease Relevance 0.73 Pain Relevance 0.88
Our present results suggest that Toxoplasma infection in LLC-bearing mice induces antitumor activity against lung cancer through the induction of a Th1-type immune response and antiangiogenic activity.
Positive_regulation (induction) of Th1-type in lung associated with lung cancer, lewis lung carcinoma and toxoplasmosis
14) Confidence 0.28 Published 2007 Journal Journal of Korean Medical Science Section Body Doc Link PMC2694397 Disease Relevance 1.14 Pain Relevance 0.04
However, it is also possible that the increased Th1/Th17 responses in the periphery versus the joint after anti-TNF?
Spec (possible) Positive_regulation (increased) of Th1 in joint
15) Confidence 0.28 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2571924 Disease Relevance 1.33 Pain Relevance 0.33
In the present study, the antibody adjuvant effect of PSP differed between the different strains of mice, both with regard to the magnitude and whether a Th2 or a mixed Th1- and Th2-associated antibody response was increased.
Positive_regulation (increased) of Th1 in PSP associated with sprains and strains
16) Confidence 0.28 Published 2005 Journal BMC Immunol Section Body Doc Link PMC1182367 Disease Relevance 0.69 Pain Relevance 0
Since successful treatment of superficial bladder cancer with BCG requires proper induction of Th1 immunity, we have developed a rBCG-S1PT strain that induced a stronger cellular immune response than BCG.
Positive_regulation (induction) of Th1 in bladder associated with bladder cancer and sprains and strains
17) Confidence 0.28 Published 2008 Journal J Exp Clin Cancer Res Section Abstract Doc Link PMC2647907 Disease Relevance 0.49 Pain Relevance 0
Our results indicate that induction of Th1 response by therapy with CpG-ODN is partially dependent on IFN-?
Positive_regulation (induction) of Th1
18) Confidence 0.27 Published 2005 Journal Respir Res Section Body Doc Link PMC555575 Disease Relevance 0.73 Pain Relevance 0.22
Serum levels of these CXCR3 ligands and local T helper type 1 (Th1) cytokines were also increased.
Positive_regulation (increased) of Th1 associated with cytokine
19) Confidence 0.27 Published 2008 Journal J Immune Based Ther Vaccines Section Abstract Doc Link PMC2583981 Disease Relevance 0.56 Pain Relevance 0.34
These findings suggest that the therapeutic effects of BCG are due in part to the rapid accumulation of antigen presenting, and activated immune cells that are responsible for the production of a multiphasic immune response as demonstrated by the presence of TH1 (IFN-?
Positive_regulation (presence) of TH1 in immune cells
20) Confidence 0.27 Published 2007 Journal BMC Immunol Section Body Doc Link PMC1891101 Disease Relevance 0.28 Pain Relevance 0.45

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