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Context Info
Confidence 0.78
First Reported 2001
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.54
Pain Relevance 0.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (COX5A) small molecule metabolic process (COX5A)
Anatomy Link Frequency
brain 1
COX5A (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 7 99.88 Very High Very High Very High
COX-2 inhibitor 1 96.68 Very High Very High Very High
Parenteral administration 1 94.08 High High
Inflammation 2 88.64 High High
Pain 1 87.52 High High
addiction 1 86.24 High High
Central nervous system 3 82.08 Quite High
Lasting pain 1 54.60 Quite High
COX2 1 25.00 Low Low
cOX1 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Pathologic Processes 1 91.12 High High
INFLAMMATION 3 88.64 High High
Pain 2 87.52 High High
Fever 1 87.04 High High
Gastrointestinal Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We also touch on the COX-1/COX-2 selectivity of NSAIDs, the localization of COX enzymes in kidneys, and clinical studies examining the renal effects of selective COX-2 inhibitors.
Localization (localization) of COX associated with cinod and cox-2 inhibitor
1) Confidence 0.78 Published 2001 Journal Am. J. Med. Sci. Section Abstract Doc Link 11269794 Disease Relevance 0.19 Pain Relevance 0.56
Data on PPIs, H(2)RAs, NSAIDs, and cyclooxygenase (COX)-2 inhibitors dispensed between 1997 and 2006 were gathered from Medicare Australia and are expressed as defined daily doses (DDDs) per 1000 concession beneficiaries per day (CBPDs).
Localization (cyclooxygenase) of COX
2) Confidence 0.73 Published 2009 Journal Clin Ther Section Body Doc Link 19446158 Disease Relevance 0 Pain Relevance 0
Furthermore, the cyclooxygenase enzymes (COX), which are responsible for the PGs biosynthesis, have been localized in the brain as well as peripherally.
Localization (localized) of COX in brain
3) Confidence 0.68 Published 2003 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 15075457 Disease Relevance 0.35 Pain Relevance 0.34

General Comments

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