INT94532

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Context Info
Confidence 0.36
First Reported 2001
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 4.25
Pain Relevance 0.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (MT2A) nucleus (MT2A) cytoplasm (MT2A)
Anatomy Link Frequency
hippocampus 2
MT2 1
bladder 1
cortex 1
MT2A (Homo sapiens)
Pain Link Frequency Relevance Heat
Hippocampus 28 100.00 Very High Very High Very High
5HT 10 100.00 Very High Very High Very High
cytokine 6 96.76 Very High Very High Very High
Spinal cord 36 95.08 Very High Very High Very High
interstitial cystitis 1 92.44 High High
Inflammation 33 75.40 Quite High
Inflammatory response 24 69.88 Quite High
Central nervous system 10 57.88 Quite High
Pain 3 53.60 Quite High
agonist 3 50.00 Quite Low
Disease Link Frequency Relevance Heat
Disease 91 100.00 Very High Very High Very High
Stress 70 98.68 Very High Very High Very High
Bladder Cancer 9 94.40 High High
Motor Neuron Diseases 321 94.16 High High
Bladder Disease 1 94.04 High High
Cystitis 1 92.96 High High
Interstitial Cystitis 1 92.44 High High
Hypoxia 18 89.96 High High
Hepatic Insufficiency 5 84.48 Quite High
Targeted Disruption 12 79.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunohistochemical analysis disclosed no immunoreactivity for MT-1 and MT-2 (designated as MT-1/2 to reflect the nonspecificity of the antibody for the two isoforms) in cells comprising the normal bladder or in nonmalignant bladder disorders, such as cystitis and interstitial cystitis.
Neg (no) Regulation (immunoreactivity) of MT-2 in bladder associated with cystitis, interstitial cystitis and bladder disease
1) Confidence 0.36 Published 2001 Journal Cancer Detect. Prev. Section Abstract Doc Link 11270423 Disease Relevance 0.72 Pain Relevance 0.09
The pharmacological activity of the metabolites for 5HT-2C, MT1, and MT2 receptors is not clearly established.
Regulation (metabolites) of MT2 in MT2 associated with 5ht
2) Confidence 0.32 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2785860 Disease Relevance 0.22 Pain Relevance 0.05
In particular, ATP1A3, EGR1, and CHGB experience opposing deregulation in the SALS motor cortex compared to the AD hippocampus, with ANXA2, ATP6V1A, EIF4A2, NSF, and all the metallothioneins detected in the hippocampus (MT1E, MT1G, MT1X, MT2A) also showing markedly different regulation between both tissues.


Regulation (regulation) of MT2A in hippocampus associated with hippocampus and disease
3) Confidence 0.14 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1796866 Disease Relevance 0.94 Pain Relevance 0.30
In particular, ATP1A3, EGR1, and CHGB experience opposing deregulation in the SALS motor cortex compared to the AD hippocampus, with ANXA2, ATP6V1A, EIF4A2, NSF, and all the metallothioneins detected in the hippocampus (MT1E, MT1G, MT1X, MT2A) also showing markedly different regulation between both tissues.


Regulation (deregulation) of MT2A in hippocampus associated with hippocampus and disease
4) Confidence 0.14 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1796866 Disease Relevance 1.05 Pain Relevance 0.32
Indicating protective responses in the SALS motor cortex, we observed the up-regulation at the mRNA level of metallothioneins (MT1E, MT1G, MT1L, MT1M, MT1X, MT2A), neuroprotective, anti-oxidant stress-response proteins induced by metal ions, cytokines, and other stress stimuli [108].
Regulation (regulation) of MT2A in cortex associated with stress and cytokine
5) Confidence 0.14 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1796866 Disease Relevance 1.32 Pain Relevance 0.22

General Comments

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