INT94534

Context Info Confidence 0.75 First Reported 2001 Last Reported 2010 Negated 0 Speculated 2 Reported most in Body Documents 8 Total Number 15 Disease Relevance 11.28 Pain Relevance 1.76

cytosol (MT2A) nucleus (MT2A) cytoplasm (MT2A)

Anatomy Link Frequency MT2 7 bladder 4 descending colon 1 forebrain 1 MT2A 1 MT2A (Homo sapiens)

Pain Link Frequency Relevance Heat Crohn's disease 240 98.32 Inflammation 36 95.88 opiate 2 93.08 dopamine receptor 2 92.76 agonist 6 92.08 interstitial cystitis 4 87.00 Nicotine 21 30.08 Bile 12 5.00 abdominal pain 9 5.00 ischemia 6 5.00

Disease Link Frequency Relevance Heat Bladder Cancer 36 99.80 Cancer 11 99.40 Nicotine Addiction 291 98.52 Disease 288 98.32 INFLAMMATION 33 95.88 Parasitic Infection 12 93.64 Sleep Disorders 2 93.48 Opisthorchiasis 18 92.40 Carcinoma In Situ 4 91.36 Infection 387 90.88

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Ramelteon inhibited forskolin-stimulated cAMP production in the CHO cells that express the human MT1 or MT2 receptors.

Gene_expression (express) of MT2 in MT2

1) Confidence 0.75 Published 2005 Journal Neuropharmacology Section Abstract Doc Link 15695169 Disease Relevance 0.06 Pain Relevance 0.25

The goals of this study were to determine the expression of metallothionein isoform 1 and 2 proteins (MT-1 and MT-2) in bladder cancer and then to determine which MT isoform-specific genes promoted the expression of these proteins.

Spec (determine) Gene_expression (expression) of MT-2 in bladder associated with bladder cancer

2) Confidence 0.63 Published 2001 Journal Cancer Detect. Prev. Section Abstract Doc Link 11270423 Disease Relevance 0.56 Pain Relevance 0.07

Ramelteon showed very high affinity for human MT1 (Mel1a) and MT2 (Mel1b) receptors (expressed in Chinese hamster ovary [CHO] cells), and chick forebrain melatonin receptors (consisting of Mel1a and Mel1c receptors) with Ki values of 14.0, 112, and 23.1 pM, respectively, making the affinities of ramelteon for these receptors 3-16 times higher than those of melatonin.

Gene_expression (expressed) of MT2 in forebrain

3) Confidence 0.58 Published 2005 Journal Neuropharmacology Section Abstract Doc Link 15695169 Disease Relevance 0.09 Pain Relevance 0.16

The MT-1 and MT-2 proteins are encoded by a family of eight genes (MT-1A, MT-1B, MT-1E, MT-1F, MT-1G, MT-IH, MT-1X, and MT-2A), and reverse transcriptase-polymerase chain reaction was used to determine which genes were expressed in the normal bladder and in bladder cancer.

Gene_expression (expressed) of MT-2A in bladder associated with bladder cancer

4) Confidence 0.49 Published 2001 Journal Cancer Detect. Prev. Section Abstract Doc Link 11270423 Disease Relevance 1.11 Pain Relevance 0.08

This analysis demonstrated that both normal and cancerous bladder tissue expressed mRNA for the MT-2A and MT-1X genes.

Gene_expression (expressed) of MT-2A in bladder

5) Confidence 0.49 Published 2001 Journal Cancer Detect. Prev. Section Abstract Doc Link 11270423 Disease Relevance 1.08 Pain Relevance 0.07

The MT-1 and MT-2 proteins are encoded by a family of eight genes (MT-1A, MT-1B, MT-1E, MT-1F, MT-1G, MT-IH, MT-1X, and MT-2A), and reverse transcriptase-polymerase chain reaction was used to determine which genes were expressed in the normal bladder and in bladder cancer.

Gene_expression (expressed) of MT-2 in bladder associated with bladder cancer

6) Confidence 0.49 Published 2001 Journal Cancer Detect. Prev. Section Abstract Doc Link 11270423 Disease Relevance 1.14 Pain Relevance 0.09

However, it might be concluded that the genes: RNF138, STEAP3 and MT2A are differently expressed in inflamed descending colonic mucosa of CD smokers versus never-smoking CD patients, supporting the notion that the colonic mucosa from that segment of CD patients is in fact affected by the patient's smoking status – a circumstance, which has to be taken into consideration when performing genome-wide gene expression profiles of CD patients and probably also of UC patients.

Gene_expression (expressed) of MT2A associated with inflammatory bowel disease, nicotine addiction and crohn's disease

7) Confidence 0.44 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2708910 Disease Relevance 2.15 Pain Relevance 0.54

In order to verify the DNA micro-array findings, the expression measures of ring finger protein 138 (RNF138), PGM2L1, metallothionein 2A (MT2A), STEAP3, and potassium inwardly-rectifying channel, subfamily J, member 2 (KCNJ2) were quantified by RT-PCR in all included samples from the CD inflamed group.

Spec (findings) Gene_expression (expression) of MT2A in MT2A associated with crohn's disease

8) Confidence 0.34 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2708910 Disease Relevance 0.82 Pain Relevance 0.15

The present study demonstrates that the genes, RNF138, MT2A, and STEAP3 are differently expressed in the inflamed descending colon of smoking versus never-smoking CD patients, which might be of relevance for the poorer clinical course among CD smokers.

Gene_expression (expressed) of MT2A in descending colon associated with nicotine addiction and crohn's disease

9) Confidence 0.34 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2708910 Disease Relevance 1.84 Pain Relevance 0.34

0.5–0.7; p<0.01), while the MT2 group had a higher PR (18.8%) than the ST1 group (POR?

Gene_expression (group) of MT2 in MT2

10) Confidence 0.21 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2821909 Disease Relevance 0.13 Pain Relevance 0

Among the groups in the heavy endemic areas, the PRs in the MT2 and MT1 groups were 18.8% and 8.4% in 2004, respectively.

Gene_expression (groups) of MT2 in MT2

11) Confidence 0.21 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2821909 Disease Relevance 0.13 Pain Relevance 0

The relative risks were significantly lower in the MT2 and ST6M groups in the heavy endemic areas and in all groups in moderate endemic areas.

Gene_expression (groups) of MT2 in MT2

12) Confidence 0.21 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2821909 Disease Relevance 1.14 Pain Relevance 0

Among 7 villages, 6 villages have a population of approximately 2,000 except for one village in Zhaoyuan (MT2 group) with a population of about 4,000.

Gene_expression (group) of MT2 in MT2

13) Confidence 0.21 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2821909 Disease Relevance 0.33 Pain Relevance 0

All the residents of the study areas were enrolled in the project except for MT2 group in Zhaoyuan County, where half of the residents were subjected for this study.

Gene_expression (group) of MT2 in MT2

14) Confidence 0.21 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2821909 Disease Relevance 0.48 Pain Relevance 0

In the high endemic areas, the MT2 group showed a higher incidence rate than the ST1 group (RR?

Gene_expression (group) of MT2 in MT2

15) Confidence 0.21 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2821909 Disease Relevance 0.20 Pain Relevance 0

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