INT94534
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
Ramelteon inhibited forskolin-stimulated cAMP production in the CHO cells that express the human MT1 or MT2 receptors. | |||||||||||||||
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The goals of this study were to determine the expression of metallothionein isoform 1 and 2 proteins (MT-1 and MT-2) in bladder cancer and then to determine which MT isoform-specific genes promoted the expression of these proteins. | |||||||||||||||
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Ramelteon showed very high affinity for human MT1 (Mel1a) and MT2 (Mel1b) receptors (expressed in Chinese hamster ovary [CHO] cells), and chick forebrain melatonin receptors (consisting of Mel1a and Mel1c receptors) with Ki values of 14.0, 112, and 23.1 pM, respectively, making the affinities of ramelteon for these receptors 3-16 times higher than those of melatonin. | |||||||||||||||
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The MT-1 and MT-2 proteins are encoded by a family of eight genes (MT-1A, MT-1B, MT-1E, MT-1F, MT-1G, MT-IH, MT-1X, and MT-2A), and reverse transcriptase-polymerase chain reaction was used to determine which genes were expressed in the normal bladder and in bladder cancer. | |||||||||||||||
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This analysis demonstrated that both normal and cancerous bladder tissue expressed mRNA for the MT-2A and MT-1X genes. | |||||||||||||||
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The MT-1 and MT-2 proteins are encoded by a family of eight genes (MT-1A, MT-1B, MT-1E, MT-1F, MT-1G, MT-IH, MT-1X, and MT-2A), and reverse transcriptase-polymerase chain reaction was used to determine which genes were expressed in the normal bladder and in bladder cancer. | |||||||||||||||
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However, it might be concluded that the genes: RNF138, STEAP3 and MT2A are differently expressed in inflamed descending colonic mucosa of CD smokers versus never-smoking CD patients, supporting the notion that the colonic mucosa from that segment of CD patients is in fact affected by the patient's smoking status a circumstance, which has to be taken into consideration when performing genome-wide gene expression profiles of CD patients and probably also of UC patients. | |||||||||||||||
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In order to verify the DNA micro-array findings, the expression measures of ring finger protein 138 (RNF138), PGM2L1, metallothionein 2A (MT2A), STEAP3, and potassium inwardly-rectifying channel, subfamily J, member 2 (KCNJ2) were quantified by RT-PCR in all included samples from the CD inflamed group. | |||||||||||||||
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The present study demonstrates that the genes, RNF138, MT2A, and STEAP3 are differently expressed in the inflamed descending colon of smoking versus never-smoking CD patients, which might be of relevance for the poorer clinical course among CD smokers. | |||||||||||||||
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0.50.7; p<0.01), while the MT2 group had a higher PR (18.8%) than the ST1 group (POR? | |||||||||||||||
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Among the groups in the heavy endemic areas, the PRs in the MT2 and MT1 groups were 18.8% and 8.4% in 2004, respectively. | |||||||||||||||
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The relative risks were significantly lower in the MT2 and ST6M groups in the heavy endemic areas and in all groups in moderate endemic areas. | |||||||||||||||
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Among 7 villages, 6 villages have a population of approximately 2,000 except for one village in Zhaoyuan (MT2 group) with a population of about 4,000. | |||||||||||||||
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All the residents of the study areas were enrolled in the project except for MT2 group in Zhaoyuan County, where half of the residents were subjected for this study. | |||||||||||||||
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In the high endemic areas, the MT2 group showed a higher incidence rate than the ST1 group (RR? | |||||||||||||||
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