INT94538

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Context Info
Confidence 0.37
First Reported 2001
Last Reported 2001
Negated 0
Speculated 1
Reported most in Abstract
Documents 1
Total Number 4
Disease Relevance 3.60
Pain Relevance 0.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transferase activity, transferring glycosyl groups (ALG1) endoplasmic reticulum (ALG1)
Anatomy Link Frequency
bladder 4
ALG1 (Homo sapiens)
Pain Link Frequency Relevance Heat
interstitial cystitis 4 98.04 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 8 99.76 Very High Very High Very High
Bladder Cancer 36 99.44 Very High Very High Very High
Carcinoma In Situ 4 99.24 Very High Very High Very High
Interstitial Cystitis 4 98.04 Very High Very High Very High
Cystitis 4 97.00 Very High Very High Very High
Bladder Disease 4 96.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunohistochemical analysis demonstrated that MT-1/2 was overexpressed in all samples of carcinoma in situ and in high-grade bladder cancer, with variable overexpression in low-grade bladder cancer and dysplastic lesions.
Gene_expression (overexpressed) of MT-1 in bladder associated with bladder cancer and carcinoma in situ
1) Confidence 0.37 Published 2001 Journal Cancer Detect. Prev. Section Abstract Doc Link 11270423 Disease Relevance 0.88 Pain Relevance 0.10
The goals of this study were to determine the expression of metallothionein isoform 1 and 2 proteins (MT-1 and MT-2) in bladder cancer and then to determine which MT isoform-specific genes promoted the expression of these proteins.
Spec (determine) Gene_expression (expression) of MT-1 in bladder associated with bladder cancer
2) Confidence 0.37 Published 2001 Journal Cancer Detect. Prev. Section Abstract Doc Link 11270423 Disease Relevance 0.55 Pain Relevance 0.07
These studies suggest that the overexpression of MT-1/2 protein in bladder cancer is a result of the overexpression of the MT-1X gene.
Gene_expression (overexpression) of MT-1 in bladder associated with bladder cancer
3) Confidence 0.37 Published 2001 Journal Cancer Detect. Prev. Section Abstract Doc Link 11270423 Disease Relevance 1.01 Pain Relevance 0.05
The MT-1 and MT-2 proteins are encoded by a family of eight genes (MT-1A, MT-1B, MT-1E, MT-1F, MT-1G, MT-IH, MT-1X, and MT-2A), and reverse transcriptase-polymerase chain reaction was used to determine which genes were expressed in the normal bladder and in bladder cancer.
Gene_expression (expressed) of MT-1 in bladder associated with bladder cancer
4) Confidence 0.29 Published 2001 Journal Cancer Detect. Prev. Section Abstract Doc Link 11270423 Disease Relevance 1.14 Pain Relevance 0.09

General Comments

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