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Context Info
Confidence 0.65
First Reported 1992
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 0.58
Pain Relevance 1.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Rnpep) extracellular space (Rnpep) extracellular region (Rnpep)
Golgi apparatus (Rnpep) plasma membrane (Rnpep)
Anatomy Link Frequency
brain 1
Rnpep (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 3 99.20 Very High Very High Very High
Analgesic 43 98.56 Very High Very High Very High
cytokine 4 91.56 High High
Opioid 25 90.88 High High
Antinociceptive 23 86.72 High High
medulla 1 86.16 High High
Potency 7 82.24 Quite High
Neuropeptide 10 79.80 Quite High
Inflammation 17 75.52 Quite High
analgesia 20 71.52 Quite High
Disease Link Frequency Relevance Heat
Adhesions 1 95.80 Very High Very High Very High
Toxicity 10 81.76 Quite High
INFLAMMATION 19 75.52 Quite High
Syndrome 5 73.36 Quite High
Systemic Lupus Erythematosus 1 68.08 Quite High
Disease 23 61.60 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 4 52.08 Quite High
Hyperalgesia 5 36.08 Quite Low
Rheumatoid Arthritis 1 33.12 Quite Low
Osteoarthritis 1 24.08 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Again, cells expressing PS1 D385TG mutants (APB10, ?)
Gene_expression (mutants) of APB
1) Confidence 0.65 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2405781 Disease Relevance 0.15 Pain Relevance 0.06
Contrary to the above cases, cell lines expressing PS1 mutants PS1-D385TG (APB10,) and PS1-D257TG/D385TG (APC5, +) did not display biphasic curves and showed inhibition of A?
Gene_expression (expressing) of APB
2) Confidence 0.58 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2405781 Disease Relevance 0.11 Pain Relevance 0
Recently, we have reported that CsA has no effect on basic and neutral aminopeptidase activities of TGE M?
Gene_expression (activities) of aminopeptidase
3) Confidence 0.07 Published 2008 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2266974 Disease Relevance 0.31 Pain Relevance 0.08
A cytosolic monkey brain aminopeptidase was responsible for cleaving tuftsin, which was inhibited by Bestatin.

Gene_expression (responsible) of aminopeptidase in brain
4) Confidence 0.04 Published 2010 Journal Frontiers in Neuroscience Section Body Doc Link PMC2903224 Disease Relevance 0 Pain Relevance 0.67
Aminopeptidase inhibitory properties and analgesic activity of (2S,3R)-3,7-diamino-2-hydroxy-heptanoic acid containing tripeptide analogues of the N-terminal tripeptide of probestin.

(2S,3R)-3,7-Diamino-2-hydroxy-heptanoyl-Leu-Pro-OH [(2S,3R)-DAHHA-Leu-Pro-OH, 4], analogue of the N-terminal tripeptide of probestin, has been synthesized, and tested as inhibitor of AP-B, Leu-AP, AP-M, and enkephalin-degrading APs, and as analgesic.

Gene_expression (synthesized) of AP-B associated with analgesic and enkephalin
5) Confidence 0.04 Published 1992 Journal Arch. Pharm. (Weinheim) Section Title Doc Link 1417460 Disease Relevance 0 Pain Relevance 0.61

General Comments

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