INT94540

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Context Info
Confidence 0.49
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 5.51
Pain Relevance 0.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (MT1X) cytoplasm (MT1X)
Anatomy Link Frequency
bladder 4
MT1X (Homo sapiens)
Pain Link Frequency Relevance Heat
interstitial cystitis 5 83.16 Quite High
methotrexate 1 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Bladder Cancer 45 99.60 Very High Very High Very High
Cancer 33 99.24 Very High Very High Very High
Apoptosis 60 91.48 High High
Carcinoma In Situ 5 87.52 High High
Colon Cancer 43 84.24 Quite High
Interstitial Cystitis 5 83.16 Quite High
Cystitis 5 82.12 Quite High
Bladder Disease 5 81.40 Quite High
Reprotox - General 1 10 43.12 Quite Low
Death 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These studies suggest that the overexpression of MT-1/2 protein in bladder cancer is a result of the overexpression of the MT-1X gene.
Gene_expression (overexpression) of MT-1X in bladder associated with bladder cancer
1) Confidence 0.49 Published 2001 Journal Cancer Detect. Prev. Section Abstract Doc Link 11270423 Disease Relevance 0.83 Pain Relevance 0
The level of MT-1X expression did not vary with tumor grade.
Gene_expression (expression) of MT-1X associated with cancer
2) Confidence 0.49 Published 2001 Journal Cancer Detect. Prev. Section Abstract Doc Link 11270423 Disease Relevance 0.95 Pain Relevance 0.06
Comparison of expression relative to that of beta-actin demonstrated that the level of MT-1X mRNA was overexpressed greatly in bladder cancer as compared to the level in normal bladder tissue.
Gene_expression (overexpressed) of MT-1X in bladder associated with bladder cancer
3) Confidence 0.42 Published 2001 Journal Cancer Detect. Prev. Section Abstract Doc Link 11270423 Disease Relevance 1.01 Pain Relevance 0.06
The MT-1 and MT-2 proteins are encoded by a family of eight genes (MT-1A, MT-1B, MT-1E, MT-1F, MT-1G, MT-IH, MT-1X, and MT-2A), and reverse transcriptase-polymerase chain reaction was used to determine which genes were expressed in the normal bladder and in bladder cancer.
Gene_expression (expressed) of MT-1X in bladder associated with bladder cancer
4) Confidence 0.38 Published 2001 Journal Cancer Detect. Prev. Section Abstract Doc Link 11270423 Disease Relevance 1.11 Pain Relevance 0.08
This analysis demonstrated that both normal and cancerous bladder tissue expressed mRNA for the MT-2A and MT-1X genes.
Gene_expression (expressed) of MT-1X in bladder
5) Confidence 0.38 Published 2001 Journal Cancer Detect. Prev. Section Abstract Doc Link 11270423 Disease Relevance 1.08 Pain Relevance 0.07
DROSHA, ITGB4, IGF1R, MT1X, MT1E, BRAF) was likewise affected by Par-4 overexpression in HT29 cells (Figure 2A; see Additional file 2 for gene symbols and their corresponding gene names).


Gene_expression (overexpression) of MT1X
6) Confidence 0.20 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2883962 Disease Relevance 0.52 Pain Relevance 0

General Comments

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