INT94540

Context Info Confidence 0.49 First Reported 2001 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 6 Total Number 6 Disease Relevance 5.51 Pain Relevance 0.28

nucleus (MT1X) cytoplasm (MT1X)

Anatomy Link Frequency bladder 4 MT1X (Homo sapiens)

Pain Link Frequency Relevance Heat interstitial cystitis 5 83.16 methotrexate 1 5.00 cINOD 1 5.00

Disease Link Frequency Relevance Heat Bladder Cancer 45 99.60 Cancer 33 99.24 Apoptosis 60 91.48 Carcinoma In Situ 5 87.52 Colon Cancer 43 84.24 Interstitial Cystitis 5 83.16 Cystitis 5 82.12 Bladder Disease 5 81.40 Reprotox - General 1 10 43.12 Death 6 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

These studies suggest that the overexpression of MT-1/2 protein in bladder cancer is a result of the overexpression of the MT-1X gene.

Gene_expression (overexpression) of MT-1X in bladder associated with bladder cancer

1) Confidence 0.49 Published 2001 Journal Cancer Detect. Prev. Section Abstract Doc Link 11270423 Disease Relevance 0.83 Pain Relevance 0

The level of MT-1X expression did not vary with tumor grade.

Gene_expression (expression) of MT-1X associated with cancer

2) Confidence 0.49 Published 2001 Journal Cancer Detect. Prev. Section Abstract Doc Link 11270423 Disease Relevance 0.95 Pain Relevance 0.06

Comparison of expression relative to that of beta-actin demonstrated that the level of MT-1X mRNA was overexpressed greatly in bladder cancer as compared to the level in normal bladder tissue.

Gene_expression (overexpressed) of MT-1X in bladder associated with bladder cancer

3) Confidence 0.42 Published 2001 Journal Cancer Detect. Prev. Section Abstract Doc Link 11270423 Disease Relevance 1.01 Pain Relevance 0.06

The MT-1 and MT-2 proteins are encoded by a family of eight genes (MT-1A, MT-1B, MT-1E, MT-1F, MT-1G, MT-IH, MT-1X, and MT-2A), and reverse transcriptase-polymerase chain reaction was used to determine which genes were expressed in the normal bladder and in bladder cancer.

Gene_expression (expressed) of MT-1X in bladder associated with bladder cancer

4) Confidence 0.38 Published 2001 Journal Cancer Detect. Prev. Section Abstract Doc Link 11270423 Disease Relevance 1.11 Pain Relevance 0.08

This analysis demonstrated that both normal and cancerous bladder tissue expressed mRNA for the MT-2A and MT-1X genes.

Gene_expression (expressed) of MT-1X in bladder

5) Confidence 0.38 Published 2001 Journal Cancer Detect. Prev. Section Abstract Doc Link 11270423 Disease Relevance 1.08 Pain Relevance 0.07

DROSHA, ITGB4, IGF1R, MT1X, MT1E, BRAF) was likewise affected by Par-4 overexpression in HT29 cells (Figure 2A; see Additional file 2 for gene symbols and their corresponding gene names).

Gene_expression (overexpression) of MT1X

6) Confidence 0.20 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2883962 Disease Relevance 0.52 Pain Relevance 0

General Comments

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