INT94545

Context Info Confidence 0.69 First Reported 2001 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 37 Total Number 37 Disease Relevance 12.91 Pain Relevance 11.19

cytoplasm (C7orf49)

Anatomy Link Frequency pons 1 tail 1 anterior 1 brain 1 median nerve 1 C7orf49 (Homo sapiens)

Pain Link Frequency Relevance Heat Anterior cingulate cortex 447 99.84 Somatosensory cortex 26 99.84 Fibrositis 80 99.82 Pain 584 99.58 Transcranial magnetic stimulation 5 99.12 Inflammation 2 98.80 addiction 254 98.70 visual analogue scale 33 98.56 imagery 429 98.32 primary somatosensory cortex 16 98.28

Disease Link Frequency Relevance Heat Anxiety Disorder 164 99.98 Fibromyalgia 80 99.82 Nociception 43 99.28 Gastroesophageal Reflux Disease 12 99.16 Pain 662 99.14 INFLAMMATION 2 98.80 Tics 306 98.68 Neurological Disease 8 98.52 Persistent Vegetative State 35 98.50 Neuropathic Pain 54 98.18

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Activated cerebellar structures were identified by colocalization of fMRI activation with the 'MRI Atlas of the Human Cerebellum'.

Positive_regulation (activation) of fMRI in Cerebellum

1) Confidence 0.69 Published 2008 Journal Cerebellum Section Abstract Doc Link 18418691 Disease Relevance 0.39 Pain Relevance 0.43

These sites of preoperative fMRI activation were integrated in an infrared-based frameless stereotactic device for surgical planning.

Positive_regulation (activation) of fMRI

2) Confidence 0.45 Published 2001 Journal Neurosurgery Section Body Doc Link 11270562 Disease Relevance 0.08 Pain Relevance 0

These sites of preoperative fMRI activation were integrated in an infrared-based frameless stereotactic device for surgical planning.

Positive_regulation (activation) of fMRI

3) Confidence 0.45 Published 2008 Journal Neurosurgery Section Body Doc Link 18695583 Disease Relevance 0.08 Pain Relevance 0

Furthermore, fMRI activation in SII did not differ across the different levels of stimulus intensity (nonpainful, painful) and attention (non-counting, counting).

Positive_regulation (activation) of fMRI in SII associated with pain and somatosensory cortex

4) Confidence 0.41 Published 2008 Journal Neuroimage Section Abstract Doc Link 18329293 Disease Relevance 0 Pain Relevance 0.98

On single-subject analysis, LEPs and fMRI activations were concentrated in relatively restricted volumes even though spatial sampling was quite different for both techniques.

Positive_regulation (activations) of fMRI

5) Confidence 0.41 Published 2002 Journal Neuroimage Section Abstract Doc Link 12414273 Disease Relevance 0.37 Pain Relevance 0.27

Time from onset of acid perfusion to instant of fMRI signal increase and first report of heartburn averaged 1.60 +/- 0.80 and 1.85 +/- 0.60 min, respectively.

Positive_regulation (increase) of fMRI associated with gastroesophageal reflux disease

6) Confidence 0.39 Published 2004 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 14512287 Disease Relevance 0.86 Pain Relevance 0.14

Other technique advances that may be helpful are increasing the fMRI data that can be used for resting state analyses.

Positive_regulation (increasing) of fMRI

7) Confidence 0.37 Published 2010 Journal Frontiers in Systems Neuroscience Section Body Doc Link PMC2893721 Disease Relevance 0 Pain Relevance 0

Results showed a statistically significant fMRI activation in bilateral SII but not in contralateral SI when the rare/deviant median nerve stimuli were delivered at nonpainful and painful levels as well as at the two levels of attention considered (i.e., associated with counting and non-counting tasks).

Positive_regulation (activation) of fMRI in median nerve associated with pain, somatosensory cortex and primary somatosensory cortex

8) Confidence 0.36 Published 2008 Journal Neuroimage Section Abstract Doc Link 18329293 Disease Relevance 0 Pain Relevance 1.00

Insular and SII cortices have been consistently shown by PET, fMRI, EPs, and MEG techniques to be activated bilaterally by a nociceptive stimulation.

Positive_regulation (activated) of fMRI associated with nociception

9) Confidence 0.24 Published 2002 Journal Neuroimage Section Abstract Doc Link 12414273 Disease Relevance 0.39 Pain Relevance 0.15

Additionally, we found that oscillatory reactivity may occur in widespread regions of the cortex not necessarily colocalized with fMRI activation observed consistently in normals performing the same task.

Positive_regulation (activation) of fMRI in cortex

10) Confidence 0.15 Published 2008 Journal Cerebral Cortex (New York, NY) Section Body Doc Link PMC2474453 Disease Relevance 0 Pain Relevance 0

Further, neuropathic pain patients would be expected to have reduced pain-evoked potential amplitudes but increased fMRI activation, different from volunteer or inflammatory models/conditions.

Positive_regulation (activation) of fMRI associated with pain, inflammation and neuropathic pain

11) Confidence 0.08 Published 2008 Journal BMC Anesthesiol Section Body Doc Link PMC2625333 Disease Relevance 0.98 Pain Relevance 1.42

Noxious heat induces fMRI activation in two anatomically distinct clusters within the nucleus accumbens.

Positive_regulation (activation) of fMRI in nucleus accumbens associated with pain and nucleus accumbens

12) Confidence 0.08 Published 2006 Journal Neurosci. Lett. Section Title Doc Link 16257488 Disease Relevance 0 Pain Relevance 0.63

These observations suggest that neurons were broadly tuned to these stimuli, especially at the intensity levels that are necessary to obtain robust fMRI activity throughout auditory cortex.

Positive_regulation (necessary) of fMRI in auditory cortex

13) Confidence 0.07 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1479693 Disease Relevance 0 Pain Relevance 0.07

To assess correlation between fMRI activation and evoked potential amplitude (or VAS scores), values collected for each subject were entered as covariates using simple regression analysis in SPM5.

Positive_regulation (activation) of fMRI associated with visual analogue scale

14) Confidence 0.06 Published 2008 Journal BMC Anesthesiol Section Body Doc Link PMC2625333 Disease Relevance 0 Pain Relevance 0.05

fMRI activation in primary motor and pre-motor regions

Positive_regulation (activation) of fMRI

15) Confidence 0.05 Published 2004 Journal Biomed Eng Online Section Body Doc Link PMC419711 Disease Relevance 0.25 Pain Relevance 0.11

It generates activation fMRI maps significant for evaluation of symmetry of activation in the frontal lobes.

Positive_regulation (activation) of fMRI in lobes

16) Confidence 0.04 Published 2004 Journal Biomed Eng Online Section Body Doc Link PMC419711 Disease Relevance 0.09 Pain Relevance 0.07

High-field MR scanner system is an advantage in fMRI

Positive_regulation (advantage) of fMRI

17) Confidence 0.04 Published 2004 Journal Biomed Eng Online Section Body Doc Link PMC419711 Disease Relevance 0 Pain Relevance 0.08

We look ahead to newer algorithms, enhanced fMRI sensitivity and spatial resolution by use of high field systems, ASL and phase array coils or newer contrast agents [74].

Positive_regulation (enhanced) of fMRI

18) Confidence 0.04 Published 2004 Journal Biomed Eng Online Section Body Doc Link PMC419711 Disease Relevance 0.29 Pain Relevance 0.13

Each FM patient underwent fMRI while moderately painful pressure was being applied.

Positive_regulation (underwent) of fMRI associated with pain and fibrositis

19) Confidence 0.04 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794529 Disease Relevance 1.37 Pain Relevance 1.16

Blood oxygenation level-dependent (BOLD)-based fMRI was performed in the visual cortex, and the foci of fMRI activation utilized as seeding points for 3D fiber reconstruction algorithms, thus provided the map of the axonal circuitry underlying visual information processing [49].

Positive_regulation (activation) of fMRI in Blood associated with addiction

20) Confidence 0.04 Published 2004 Journal Biomed Eng Online Section Body Doc Link PMC419711 Disease Relevance 0 Pain Relevance 0.05

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