INT94546

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Context Info
Confidence 0.56
First Reported 2001
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 13
Total Number 15
Disease Relevance 6.99
Pain Relevance 0.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Fas) aging (Fas) extracellular region (Fas)
plasma membrane (Fas) nucleus (Fas) cytoplasm (Fas)
Anatomy Link Frequency
pancreas 2
acinar cells 2
smooth muscle cells 1
Fas (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammatory response 2 98.40 Very High Very High Very High
Chronic pancreatitis 12 91.96 High High
Inflammation 18 81.00 Quite High
cytokine 14 71.68 Quite High
antagonist 8 61.80 Quite High
anesthesia 8 30.44 Quite Low
alcohol 8 10.28 Low Low
cerebral cortex 18 5.00 Very Low Very Low Very Low
tolerance 9 5.00 Very Low Very Low Very Low
metalloproteinase 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 182 99.18 Very High Very High Very High
Hypersensitivity 212 99.12 Very High Very High Very High
INFLAMMATION 21 98.40 Very High Very High Very High
Disorder Of Lipid Metabolism 96 97.24 Very High Very High Very High
Hepatocellular Cancer 4 95.30 Very High Very High Very High
Repression 4 93.48 High High
Cancer 13 92.60 High High
Pancreatitis 12 91.96 High High
Stress 32 88.28 High High
Chorioamnionitis 66 85.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Meanwhile, the mRNA expression of its response genes, FAS, ME and G6PDH, were also determined.
Spec (determined) Transcription (expression) of FAS
1) Confidence 0.56 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2846940 Disease Relevance 0.60 Pain Relevance 0
An apoptotic index in acinar cells correlated to the expression of Fas and FasL mRNA.
Transcription (expression) of Fas in acinar cells
2) Confidence 0.52 Published 2007 Journal Pancreatology Section Body Doc Link 17449963 Disease Relevance 0.07 Pain Relevance 0
Fas and FasL mRNAs in the pancreas were detected with a reverse transcription-polymerase chain reaction method.
Transcription (detected) of Fas in pancreas
3) Confidence 0.51 Published 2001 Journal Dig. Dis. Sci. Section Abstract Doc Link 11270781 Disease Relevance 0.73 Pain Relevance 0.22
Fas and FasL mRNA were expressed when the pancreas was still pathologically normal, and showed a biphasic peak at 12 and 20 weeks.
Transcription (expressed) of Fas in pancreas
4) Confidence 0.51 Published 2001 Journal Dig. Dis. Sci. Section Abstract Doc Link 11270781 Disease Relevance 0.69 Pain Relevance 0.25
An apoptotic index in acinar cells correlated to the expression of Fas and FasL mRNAs.
Transcription (expression) of Fas in acinar cells associated with apoptosis
5) Confidence 0.51 Published 2001 Journal Dig. Dis. Sci. Section Abstract Doc Link 11270781 Disease Relevance 0.62 Pain Relevance 0.24
FAS, ME and G6PDH mRNA expression was downregulated by SSC treatment, with a decrease of 20.1% (P < 0.05), 33.9% (P < 0.05) and 26.7% (P < 0.05) separately (Figure 3).


Transcription (expression) of FAS associated with hypersensitivity
6) Confidence 0.42 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2846940 Disease Relevance 0.48 Pain Relevance 0
The results suggested that the stimulated FAS, ME and G6PDH transcription may occur after SREBP-1c activation caused by OA.
Transcription (transcription) of FAS
7) Confidence 0.42 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2846940 Disease Relevance 0.53 Pain Relevance 0
As a result of the low SREBP-1c expression in rats fed SSC, there was a concomitant significant reduction in the expression of FAS, ME and G6PDH mRNA.
Transcription (expression) of FAS associated with hypersensitivity
8) Confidence 0.42 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2846940 Disease Relevance 0.60 Pain Relevance 0
Both the mouse and human Fas genes contain a p53 response element (p53RE) within intron #1 that drives transcription of the Fas gene [33].
Transcription (transcription) of Fas
9) Confidence 0.41 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.21 Pain Relevance 0.03
Consistent with the activity of the enzymes correlated to lipogenesis capacity, mRNA expression of FAS, G6PDH and ME decreased (35%,59% and 44%) (P < 0.01)dramatically by dietary cholesterol (Figure 1A).
Transcription (expression) of FAS associated with disorder of lipid metabolism
10) Confidence 0.34 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2820024 Disease Relevance 0.18 Pain Relevance 0
Quantitative RT-PCR for Fas ligand mRNA expression
Transcription (expression) of Fas
11) Confidence 0.33 Published 2004 Journal Comp Hepatol Section Body Doc Link PMC2410251 Disease Relevance 0 Pain Relevance 0
The functional significance of these polymorphisms has not been fully elucidated but they may modulate TNFRSF6 transcription, Fas expression and thus apoptotic and inflammatory responses.
Transcription (transcription) of TNFRSF6 associated with inflammatory response and apoptosis
12) Confidence 0.32 Published 2005 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC554771 Disease Relevance 1.20 Pain Relevance 0.14
Actually, recent findings showed that human hepatoma HepG2 cells which were treated with H2O2 accumulated triglycerides through up-regulation of genes encoding SREBP-1c and other genes involved in fatty acid metabolism [8], and experiments from our research group revealed a higher mRNA expression of fatty acid synthase (FAS), glucose-6-phosphate dehydrogenase (G6PDH) and stearoyl-CoA desaturase (SCD)-1 in HepG2 cells treated with pro-oxidant CuSO4 compared to untreated cells [9].
Transcription (expression) of FAS associated with hepatocellular cancer
13) Confidence 0.31 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2881051 Disease Relevance 0.75 Pain Relevance 0
The transcription factor p53 induces Fas gene transcription [33], the translocation of Fas from Golgi complex to cell surface [34], and activates Fas-mediated apoptosis in un-transformed vascular smooth muscle cells [34] and mammary epithelial tumors [35].
Transcription (transcription) of Fas in smooth muscle cells associated with cancer and apoptosis
14) Confidence 0.31 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.35 Pain Relevance 0
Synthesis of cDNA and determination of mRNA abundance of SREBP-1c, FAS (EC 2.3.1.85), DGAT-2 (EC 2.3.1.20), S14, PTB1B (EC 3.1.3.48), XBP1 in native and spliced form, IRE-1 and glyceraldehyd-3-phosphat dehydrogenase (GAPDH) were performed by real-time detection PCR as recently described in detail [9].
Transcription (abundance) of FAS
15) Confidence 0.23 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2881051 Disease Relevance 0 Pain Relevance 0

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