INT94548

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Context Info
Confidence 0.77
First Reported 2001
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 9
Total Number 10
Disease Relevance 5.15
Pain Relevance 0.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Fas) aging (Fas) extracellular region (Fas)
plasma membrane (Fas) nucleus (Fas) cytoplasm (Fas)
Anatomy Link Frequency
lymphocyte 1
apoptotic cells 1
smooth muscle cells 1
neural 1
Fas (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 2 100.00 Very High Very High Very High
abdominal pain 1 92.24 High High
Inflammation 3 91.36 High High
cerebral cortex 54 90.92 High High
Chronic pancreatitis 3 86.96 High High
alcohol 7 86.24 High High
antagonist 18 77.56 Quite High
Hippocampus 6 63.56 Quite High
withdrawal 4 60.80 Quite High
metalloproteinase 24 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 512 98.94 Very High Very High Very High
Death 137 95.76 Very High Very High Very High
Cancer 25 93.84 High High
Injury 100 92.84 High High
Abdominal Pain 1 92.24 High High
INFLAMMATION 3 91.36 High High
Sepsis 49 89.32 High High
Pancreatitis 3 86.96 High High
Infection 14 85.20 High High
Suicidal Behaviour 162 84.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The cellular localization of Fas and FasL mRNA and protein was determined with in situ hybridization (ISH) and immunohistochemistry (IHC).
Localization (localization) of Fas
1) Confidence 0.77 Published 2001 Journal Dig. Dis. Sci. Section Abstract Doc Link 11270781 Disease Relevance 0.71 Pain Relevance 0.21
Our experiments focused predominantly on the pool of Fas receptors that localized to the cell surface, because this population constitutes the bioactive proportion of Fas receptors that contributes to apoptosis sensitivity.
Localization (localized) of Fas associated with apoptosis
2) Confidence 0.46 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.50 Pain Relevance 0.12
One issue that remains to be addressed is whether estrogen suppresses cell-surface Fas expression by acting as a non-classical transcription repressor, or by suppressing translocation of Fas from intracellular compartments to the cell-surface in a manner that is antagonistic to that observed for p53 [34].
Localization (translocation) of Fas
3) Confidence 0.46 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.27 Pain Relevance 0.04
Earlier studies have proposed a possibility that if Fas-cross linking be increased to 20h, the percentage of apoptotic cells may fall gradually; possibly owing to gradual deletion of Fas-sensitive cells however we did not investigate later time points in the present study.


Localization (deletion) of Fas in apoptotic cells associated with apoptosis
4) Confidence 0.41 Published 2007 Journal International Journal of Biological Sciences Section Body Doc Link PMC1989035 Disease Relevance 1.64 Pain Relevance 0.03
Co-localization of Fas with FADD and FLIP
Localization (localization) of Fas
5) Confidence 0.41 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.26 Pain Relevance 0
Collectively, these data indicate that only a fraction (~1/4th) of all Fas-expressing cells actually localize Fas to the cell-surface, in vitro.


Localization (localize) of Fas
6) Confidence 0.41 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.25 Pain Relevance 0
The transcription factor p53 induces Fas gene transcription [33], the translocation of Fas from Golgi complex to cell surface [34], and activates Fas-mediated apoptosis in un-transformed vascular smooth muscle cells [34] and mammary epithelial tumors [35].
Localization (translocation) of Fas in smooth muscle cells associated with cancer and apoptosis
7) Confidence 0.41 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.35 Pain Relevance 0
In the initial experiment, we utilized flow cytometric analysis to examine the localization of Fas to the cell surface of freshly isolated embryonic rat (gestational day (GD)-15) cortical neural cells by immuno-labeling for Fas in the absence of detergent.
Spec (examine) Localization (localization) of Fas in neural
8) Confidence 0.41 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.19 Pain Relevance 0.03
Different lymphocyte subsets were quantified on the basis of surface antigen expression (CD3, CD4, CD8, CD20), secreted cytokines (IL-4, IL-6, IFNgamma) and Fas and FasL proteins in the gastric mucosa.
Localization (secreted) of Fas in lymphocyte associated with cytokine
9) Confidence 0.13 Published 2009 Journal Acta Biochim. Pol. Section Abstract Doc Link 19572057 Disease Relevance 0.57 Pain Relevance 0.19
We conducted readability and usability testing of the survey on a sample of 30 volunteers who were active or retired FAs.
Localization (retired) of FAs
10) Confidence 0.05 Published 2007 Journal Environ Health Section Body Doc Link PMC2064907 Disease Relevance 0.40 Pain Relevance 0.04

General Comments

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