INT9455

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Context Info
Confidence 0.31
First Reported 1982
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 0.52
Pain Relevance 2.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Rnpep) extracellular space (Rnpep) extracellular region (Rnpep)
Golgi apparatus (Rnpep) plasma membrane (Rnpep)
Anatomy Link Frequency
brain 1
Rnpep (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 11 99.20 Very High Very High Very High
narcan 24 99.02 Very High Very High Very High
antinociception 32 98.08 Very High Very High Very High
Analgesic 42 97.88 Very High Very High Very High
Dorsal horn 1 92.28 High High
Hyperalgesia 3 90.24 High High
antagonist 9 88.64 High High
Antinociceptive 24 86.72 High High
Opioid 24 65.32 Quite High
Pain 7 56.96 Quite High
Disease Link Frequency Relevance Heat
Hyperalgesia 3 90.24 High High
Amnesia 2 89.80 High High
Cognitive Disorder 9 75.00 Quite High
Nociception 6 75.00 Quite High
Stress 1 66.76 Quite High
Injury 2 64.72 Quite High
Pain 14 56.96 Quite High
Disease 18 5.00 Very Low Very Low Very Low
Targeted Disruption 8 5.00 Very Low Very Low Very Low
Alzheimer's Dementia 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
L-Ornithine and L-arginine, when given i.c.v. at 10-100 mu g/mouse, elicited antinociception even in intact mice, the effects being abolished by naloxone or naltrindole, and potentiated by bestatin, an inhibitor of aminopeptidase and kyotorphinase.
Negative_regulation (inhibitor) of aminopeptidase associated with antinociception and narcan
1) Confidence 0.31 Published 1996 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8720473 Disease Relevance 0.09 Pain Relevance 0.81
The effects of thiorphan on brain met5-enkephalin content and hot plate latencies were significantly potentiated by bestatin, which inhibits aminopeptidase B and leucine aminopeptidase.
Negative_regulation (inhibits) of aminopeptidase B in brain associated with enkephalin
2) Confidence 0.26 Published 1982 Journal Neuropharmacology Section Abstract Doc Link 6750433 Disease Relevance 0.07 Pain Relevance 0.49
Aminopeptidase inhibitory properties and analgesic activity of (2S,3R)-3,7-diamino-2-hydroxy-heptanoic acid containing tripeptide analogues of the N-terminal tripeptide of probestin.

(2S,3R)-3,7-Diamino-2-hydroxy-heptanoyl-Leu-Pro-OH [(2S,3R)-DAHHA-Leu-Pro-OH, 4], analogue of the N-terminal tripeptide of probestin, has been synthesized, and tested as inhibitor of AP-B, Leu-AP, AP-M, and enkephalin-degrading APs, and as analgesic.

Negative_regulation (inhibitor) of AP-B associated with analgesic and enkephalin
3) Confidence 0.03 Published 1992 Journal Arch. Pharm. (Weinheim) Section Title Doc Link 1417460 Disease Relevance 0 Pain Relevance 0.61
These inhibitors were Bestatin, a non-specific aminopeptidase inhibitor, Thiorphan, an inhibitor of NEP and Kelatorphan, a mixed inhibitor of several aminopeptidases, all of which enhanced the antinociception under the experiment with Kelatorphan to be the most efficient one.
Negative_regulation (inhibitor) of aminopeptidase associated with antinociception
4) Confidence 0.02 Published 2010 Journal Frontiers in Neuroscience Section Body Doc Link PMC2903224 Disease Relevance 0.19 Pain Relevance 0.56
However, the mechanism of action is still unknown but may involve inhibition of the aminopeptidase activity of IRAP, since both angiotensin IV and LVV-hemorphin 7 are competitive inhibitors of the enzyme.
Negative_regulation (inhibition) of aminopeptidase
5) Confidence 0.02 Published 2008 Journal BMC Neurosci Section Abstract Doc Link PMC2604898 Disease Relevance 0.16 Pain Relevance 0

General Comments

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