INT94550

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Context Info
Confidence 0.38
First Reported 2001
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0
Pain Relevance 0.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (CYP2C19) oxidoreductase activity (CYP2C19) endoplasmic reticulum (CYP2C19)
enzyme binding (CYP2C19)
CYP2C19 (Homo sapiens)
Pain Link Frequency Relevance Heat
fluoxetine 10 99.70 Very High Very High Very High
opiate 5 51.20 Quite High
Nicotine 32 5.00 Very Low Very Low Very Low
Dopamine 14 5.00 Very Low Very Low Very Low
Nucleus accumbens 8 5.00 Very Low Very Low Very Low
addiction 6 5.00 Very Low Very Low Very Low
Ventral tegmentum 5 5.00 Very Low Very Low Very Low
Peripheral nervous system 5 5.00 Very Low Very Low Very Low
cocaine 4 5.00 Very Low Very Low Very Low
cannabis 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Myelodysplastic Syndromes 16 5.00 Very Low Very Low Very Low
Vomiting 6 5.00 Very Low Very Low Very Low
Worm Infection 4 5.00 Very Low Very Low Very Low
Infection 4 5.00 Very Low Very Low Very Low
Stress 2 5.00 Very Low Very Low Very Low
Cerebral Palsy 1 5.00 Very Low Very Low Very Low
Bacterial Infection 1 5.00 Very Low Very Low Very Low
Malaria 1 5.00 Very Low Very Low Very Low
Sleep Disorders 1 5.00 Very Low Very Low Very Low
Tremor 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Fluoxetine substantially inhibited the metabolism of the CYP2C19 substrate (S)-mephenytoin.
Negative_regulation (inhibited) of Gene_expression (metabolism) of CYP2C19 associated with fluoxetine
1) Confidence 0.38 Published 2001 Journal J Clin Psychopharmacol Section Abstract Doc Link 11270912 Disease Relevance 0 Pain Relevance 0.69
For several key enzymes, CYP1A2, CYP2A6, CYP2C19 and CYP2E1, these ratios were particularly low (?
Negative_regulation (low) of Gene_expression (enzymes) of CYP2C19
2) Confidence 0.27 Published 2008 Journal Proceedings of the Royal Society B: Biological Sciences Section Body Doc Link PMC2367444 Disease Relevance 0 Pain Relevance 0.05

General Comments

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