INT9456

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Context Info
Confidence 0.78
First Reported 1992
Last Reported 2008
Negated 1
Speculated 1
Reported most in Abstract
Documents 9
Total Number 13
Disease Relevance 1.69
Pain Relevance 4.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Anpep) peptidase activity (Anpep)
Anatomy Link Frequency
brain 2
spinal cord 1
Anpep (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 16 99.84 Very High Very High Very High
Analgesic 4 98.44 Very High Very High Very High
Spinal cord 9 98.40 Very High Very High Very High
Opioid 4 97.48 Very High Very High Very High
Neuropeptide 4 96.44 Very High Very High Very High
Pain 71 94.44 High High
Limbic system 4 94.40 High High
Hippocampus 5 92.60 High High
Antinociceptive 3 87.28 High High
Raphe 3 82.92 Quite High
Disease Link Frequency Relevance Heat
Mental Disorders 56 98.24 Very High Very High Very High
Pain 70 94.44 High High
Urological Neuroanatomy 5 91.16 High High
Disease 16 63.68 Quite High
Knee Injuries 4 60.32 Quite High
Frailty 16 59.04 Quite High
Arthritis 8 50.00 Quite Low
Athletic Injuries 4 25.44 Quite Low
Knee Osteoarthritis 4 5.00 Very Low Very Low Very Low
Hip Osteoarthritis 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This iodinated probe could allow the ex vivo and in vivo localization of aminopeptidase N in various tissues to be investigated and may also be used to evaluate quantitative changes in aminopeptidase N expression in pathological situations.
Gene_expression (expression) of aminopeptidase N
1) Confidence 0.78 Published 2001 Journal Neuroscience Section Abstract Doc Link 11672613 Disease Relevance 0.05 Pain Relevance 0.59
First discrete autoradiographic distribution of aminopeptidase N in various structures of rat brain and spinal cord using the selective iodinated inhibitor [125I]RB 129.
Gene_expression (distribution) of aminopeptidase N in brain associated with spinal cord
2) Confidence 0.67 Published 2001 Journal Neuroscience Section Title Doc Link 11672613 Disease Relevance 0.07 Pain Relevance 0.47
The coordinated changes (in some regions) of NEP and APN expression were opposite to those previously observed for PPII mRNA and activity levels in limbic regions.
Gene_expression (expression) of APN
3) Confidence 0.61 Published 2007 Journal J. Mol. Neurosci. Section Abstract Doc Link 17952634 Disease Relevance 0.09 Pain Relevance 0.24
To understand the specificity of this phenomenon, we studied APN and NEP expression in brains of partially or fully kindled rats (stage II and V), sacrificed 6 h after last stimulus, compared with sham-operated animals.
Gene_expression (expression) of APN in brains
4) Confidence 0.42 Published 2007 Journal J. Mol. Neurosci. Section Abstract Doc Link 17952634 Disease Relevance 0.06 Pain Relevance 0.30
High performance liquid chromatography and high performance liquid chromatography/electrospray ionization-mass spectrometry were used to study the effect of N-terminal acetylation and the inhibition activity of acetylated enkephalins on the aminopeptidase M (EC 3.4.11.2)-catalyzed hydrolysis of methionine (Met-enk) and leucine enkephalins (Leu-enk).
Gene_expression (hydrolysis) of aminopeptidase M associated with enkephalin
5) Confidence 0.32 Published 1999 Journal Peptides Section Abstract Doc Link 10503775 Disease Relevance 0 Pain Relevance 0.43
First discrete autoradiographic distribution of aminopeptidase N in various structures of rat brain and spinal cord using the selective iodinated inhibitor [125I]RB 129.
Gene_expression (distribution) of aminopeptidase N in spinal cord associated with spinal cord
6) Confidence 0.23 Published 2001 Journal Neuroscience Section Title Doc Link 11672613 Disease Relevance 0.07 Pain Relevance 0.47
Aminopeptidase inhibitory properties and analgesic activity of (2S,3R)-3,7-diamino-2-hydroxy-heptanoic acid containing tripeptide analogues of the N-terminal tripeptide of probestin.

(2S,3R)-3,7-Diamino-2-hydroxy-heptanoyl-Leu-Pro-OH [(2S,3R)-DAHHA-Leu-Pro-OH, 4], analogue of the N-terminal tripeptide of probestin, has been synthesized, and tested as inhibitor of AP-B, Leu-AP, AP-M, and enkephalin-degrading APs, and as analgesic.

Gene_expression (synthesized) of AP-M associated with analgesic and enkephalin
7) Confidence 0.07 Published 1992 Journal Arch. Pharm. (Weinheim) Section Title Doc Link 1417460 Disease Relevance 0 Pain Relevance 0.61
The potential EI targets appear to be APN (Aminopeptidase N), NEP (Neutral endopeptidase), DPP-III (Dipeptidyl peptidase).
Spec (appear) Gene_expression (appear) of APN
8) Confidence 0.06 Published 2008 Journal Curr Drug Targets Section Abstract Doc Link 18855623 Disease Relevance 0.14 Pain Relevance 0.45
EMR conceived of the study, participated in the design of the study, carried out data collection,TKR, APM, and ACL studies, and helped to draft the manuscript.
Gene_expression (collection) of APM
9) Confidence 0.06 Published 2008 Journal Health Qual Life Outcomes Section Body Doc Link PMC2527304 Disease Relevance 0 Pain Relevance 0
More troublesome for documenting potential improvements in scores were ceiling effects at baseline, which were observed in the SF and RE subscales for all groups and in the RP and GH subscales for APM group.
Gene_expression (group) of APM
10) Confidence 0.06 Published 2008 Journal Health Qual Life Outcomes Section Body Doc Link PMC2527304 Disease Relevance 0.37 Pain Relevance 0.18
Although no comparable data are currently available for APM, previous studies with THR, TKR, and ACL patients also documented greatest changes in the physical domains [18,38-42].
Neg (no) Gene_expression (available) of APM
11) Confidence 0.06 Published 2008 Journal Health Qual Life Outcomes Section Body Doc Link PMC2527304 Disease Relevance 0.43 Pain Relevance 0.15
One exception was the GH subscale, with small deteriorations relative to baseline scores recorded for THR and TKR groups at five years and for the APM group at three months follow-up.
Gene_expression (groups) of APM
12) Confidence 0.06 Published 2008 Journal Health Qual Life Outcomes Section Body Doc Link PMC2527304 Disease Relevance 0.40 Pain Relevance 0.21
The native endomorphin-1, H-Tyr-Pro-Trp-Phe-NH2 (1), and endomorphin-2, H-Tyr-Pro-Phe-Phe-NH2 (2), and an analog of endomorphin-2, H-Tyr-Pro-Phe-Phe-OH (3), were synthetized, and the levels of their resistance against carboxypeptidase A, carboxypeptidase Y, aminopeptidase M and proteinase A were determined.
Gene_expression (resistance) of aminopeptidase M
13) Confidence 0.03 Published 1999 Journal J Chromatogr A Section Abstract Doc Link 10420597 Disease Relevance 0 Pain Relevance 0.16

General Comments

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