INT94563

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Context Info
Confidence 0.42
First Reported 1998
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 9
Disease Relevance 7.00
Pain Relevance 0.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
cerebral cortex 1
neurons 1
striatum 1
cerebellar cortex 1
H2-Q10 (Mus musculus)
H2-Q10 - Q10R (1)
Pain Link Frequency Relevance Heat
cerebral cortex 5 99.68 Very High Very High Very High
hyperexcitability 1 99.64 Very High Very High Very High
dorsal root ganglion 4 98.80 Very High Very High Very High
Angina 4 96.40 Very High Very High Very High
imagery 14 82.68 Quite High
sodium channel 2 73.44 Quite High
burning pain 1 69.28 Quite High
Spinal cord 10 38.96 Quite Low
Peripheral nervous system 2 33.68 Quite Low
Pain 3 32.48 Quite Low
Disease Link Frequency Relevance Heat
Hypolipidemia 18 99.80 Very High Very High Very High
Cerebellar Ataxia 96 99.76 Very High Very High Very High
Friedreich Ataxia 106 99.28 Very High Very High Very High
Ganglion Cysts 5 98.80 Very High Very High Very High
Erythermalgia 8 98.40 Very High Very High Very High
Coronary Artery Disease 7 98.04 Very High Very High Very High
Hepatotoxicity 4 97.40 Very High Very High Very High
Syndrome 66 97.28 Very High Very High Very High
Stress 307 97.24 Very High Very High Very High
Coronary Heart Disease 14 97.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Preliminary data also demonstrate significant increases in Coenzyme Q9 and Q10 levels in the cerebral cortex, striatum, and cerebellar cortex of dwarf mice (Brown-Borg and Sharma, unpublished data).
Gene_expression (levels) of Q10 in cerebellar cortex associated with cerebral cortex
1) Confidence 0.42 Published 2006 Journal Age (Dordr) Section Body Doc Link PMC2464727 Disease Relevance 0.24 Pain Relevance 0.05
Preliminary data also demonstrate significant increases in Coenzyme Q9 and Q10 levels in the cerebral cortex, striatum, and cerebellar cortex of dwarf mice (Brown-Borg and Sharma, unpublished data).
Gene_expression (levels) of Q10 in cerebral cortex associated with cerebral cortex
2) Confidence 0.14 Published 2006 Journal Age (Dordr) Section Body Doc Link PMC2464727 Disease Relevance 0.24 Pain Relevance 0.05
Preliminary data also demonstrate significant increases in Coenzyme Q9 and Q10 levels in the cerebral cortex, striatum, and cerebellar cortex of dwarf mice (Brown-Borg and Sharma, unpublished data).
Gene_expression (levels) of Q10 in striatum associated with cerebral cortex
3) Confidence 0.14 Published 2006 Journal Age (Dordr) Section Body Doc Link PMC2464727 Disease Relevance 0.24 Pain Relevance 0.05
Coenzyme Q10 is normally present in the low density lipoprotein cholesterol fraction and inhibits its oxidation.
Gene_expression (present) of Q10
4) Confidence 0.12 Published 1998 Journal J Assoc Physicians India Section Abstract Doc Link 11273351 Disease Relevance 1.10 Pain Relevance 0.17
Coenzyme Q10 is known for producing minor gastrointestinal discomfort and elevation in SGOT and LDH when used.
Gene_expression (producing) of Q10
5) Confidence 0.12 Published 1998 Journal J Assoc Physicians India Section Abstract Doc Link 11273351 Disease Relevance 1.03 Pain Relevance 0.16
For most ARCA there is no specific drug treatment except for coenzyme Q10 deficiency and abetalipoproteinemia.



Gene_expression (deficiency) of Q10 associated with hypolipidemia and cerebellar ataxia
6) Confidence 0.07 Published 2006 Journal Orphanet J Rare Dis Section Abstract Doc Link PMC1664553 Disease Relevance 1.15 Pain Relevance 0.04
Coenzyme Q10 deficiency with cerebellar ataxia
Gene_expression (deficiency) of Q10 associated with cerebellar ataxia
7) Confidence 0.07 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1664553 Disease Relevance 1.33 Pain Relevance 0
Using current-clamp, we show that the expression of Q10R induces hyperexcitability in DRG neurons, but produces an increase in excitability that is smaller than the change produced by I848T, an early-onset erythromelalgia mutation.
Gene_expression (expression) of Q10R (Q10R) in neurons associated with dorsal root ganglion, erythermalgia and hyperexcitability
8) Confidence 0.02 Published 2009 Journal Brain Section Abstract Doc Link 19369487 Disease Relevance 1.13 Pain Relevance 0.35
In addition, enhanced levels of H2CoQ10 and NADPH-CoQ reductase activity showed more resistant to oxidative stress than those of normal levels.
Gene_expression (levels) of H2CoQ10 associated with stress
9) Confidence 0.01 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2275764 Disease Relevance 0.54 Pain Relevance 0

General Comments

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