INT9457

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Context Info
Confidence 0.57
First Reported 1992
Last Reported 1992
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0
Pain Relevance 1.02

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peptidase activity (KLK3) extracellular region (KLK3)
KLK3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 4 100.00 Very High Very High Very High
Analgesic 8 99.64 Very High Very High Very High
Antinociceptive 2 99.04 Very High Very High Very High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Aminopeptidase inhibitory properties and analgesic activity of (2S,3R)-3,7-diamino-2-hydroxy-heptanoic acid containing tripeptide analogues of the N-terminal tripeptide of probestin.

(2S,3R)-3,7-Diamino-2-hydroxy-heptanoyl-Leu-Pro-OH [(2S,3R)-DAHHA-Leu-Pro-OH, 4], analogue of the N-terminal tripeptide of probestin, has been synthesized, and tested as inhibitor of AP-B, Leu-AP, AP-M, and enkephalin-degrading APs, and as analgesic.

Negative_regulation (inhibitor) of APs associated with analgesic and enkephalin
1) Confidence 0.57 Published 1992 Journal Arch. Pharm. (Weinheim) Section Title Doc Link 1417460 Disease Relevance 0 Pain Relevance 0.61
Compounds 4 and 6 were potent and selective inhibitors of enkephalin-degrading APs and showed a prolonged antinociceptive effect.
Negative_regulation (inhibitors) of APs associated with enkephalin and antinociceptive
2) Confidence 0.42 Published 1992 Journal Arch. Pharm. (Weinheim) Section Abstract Doc Link 1417460 Disease Relevance 0 Pain Relevance 0.41

General Comments

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