INT94573

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.50
First Reported 2001
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 42
Total Number 47
Disease Relevance 15.83
Pain Relevance 15.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pik3cb) signal transduction (Pik3cb) cell adhesion (Pik3cb)
nucleus (Pik3cb) cytoplasm (Pik3cb)
Anatomy Link Frequency
striatum 4
hearts 3
plasma 2
neurons 2
SH-SY5Y 1
Pik3cb (Rattus norvegicus)
Pain Link Frequency Relevance Heat
qutenza 28 99.42 Very High Very High Very High
antagonist 139 99.34 Very High Very High Very High
ischemia 339 99.16 Very High Very High Very High
Inflammation 173 99.14 Very High Very High Very High
opioid receptor 266 99.08 Very High Very High Very High
agonist 116 98.94 Very High Very High Very High
Hyperalgesia 20 98.88 Very High Very High Very High
Dopamine 1032 98.84 Very High Very High Very High
Opioid 46 98.68 Very High Very High Very High
narcan 6 98.12 Very High Very High Very High
Disease Link Frequency Relevance Heat
Apoptosis 200 99.76 Very High Very High Very High
Death 89 99.68 Very High Very High Very High
Bordatella Infection 4 99.68 Very High Very High Very High
Cv Unclassified Under Development 197 99.16 Very High Very High Very High
INFLAMMATION 190 99.14 Very High Very High Very High
Hyperalgesia 20 98.88 Very High Very High Very High
Sepsis 131 98.76 Very High Very High Very High
Cancer 39 98.56 Very High Very High Very High
Disease 61 98.52 Very High Very High Very High
Suicidal Behaviour 1 98.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The inhibition of PI3K led to a significant reduction in the ability of AMPH infusions to induce DA efflux 45 and 90 min after treatment (Figure 3).
Negative_regulation (inhibition) of PI3K associated with dopamine
1) Confidence 0.50 Published 2007 Journal PLoS Biology Section Body Doc Link PMC2020502 Disease Relevance 0 Pain Relevance 0.33
Importantly, selective inhibition of PI3K with LY294002 within the striatum results in a profound reduction in the subsequent potential for AMPH to evoke DA efflux.
Negative_regulation (inhibition) of PI3K in striatum associated with dopamine
2) Confidence 0.50 Published 2007 Journal PLoS Biology Section Abstract Doc Link PMC2020502 Disease Relevance 0 Pain Relevance 0.29
In contrast, in vitro inhibition of either PI3K or Akt causes a decrease in DA uptake capacity and a redistribution of DAT away from the plasma membrane [11,13].
Negative_regulation (inhibition) of PI3K in plasma associated with dopamine
3) Confidence 0.50 Published 2007 Journal PLoS Biology Section Body Doc Link PMC2020502 Disease Relevance 0.06 Pain Relevance 0.33
Injection of PI3K or MEK (ERK kinase) inhibitors into the hindpaw attenuated capsaicin- and NGF-evoked heat hyperalgesia but did not change basal heat sensitivity.
Negative_regulation (inhibitors) of PI3K associated with hyperalgesia and qutenza
4) Confidence 0.42 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15385613 Disease Relevance 0.74 Pain Relevance 1.29
In acutely dissociated DRG neurons, the capsaicin-induced TRPV1 current was strikingly potentiated by NGF, and this potentiation was completely blocked by PI3K inhibitors and primarily suppressed by MEK inhibitors.
Negative_regulation (inhibitors) of PI3K in neurons associated with qutenza
5) Confidence 0.42 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15385613 Disease Relevance 0.60 Pain Relevance 1.16
ERK activation by capsaicin and NGF was also blocked by PI3K inhibitors.
Negative_regulation (inhibitors) of PI3K associated with qutenza
6) Confidence 0.42 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15385613 Disease Relevance 0.73 Pain Relevance 1.26
Furthermore, PI3K, but not ERK, inhibition blocked early induction of hyperalgesia.
Negative_regulation (inhibition) of PI3K associated with hyperalgesia
7) Confidence 0.42 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15385613 Disease Relevance 0.74 Pain Relevance 1.33
Because insulin and PI3K signaling have been shown to fine-tune DAT cell surface expression [13,29], it is possible that inhibition of PI3K signaling in vivo, by reducing DAT cell surface expression, inhibits AMPH-induced DA efflux and, hence, its behavioral effects.
Spec (possible) Negative_regulation (inhibition) of PI3K associated with dopamine
8) Confidence 0.36 Published 2007 Journal PLoS Biology Section Body Doc Link PMC2020502 Disease Relevance 0.06 Pain Relevance 0.42
In three independent experiments, STZ treatment in rats led to a 44 ± 16% decrease in Akt activity measured from striatal synaptosomes (Figure 1B), suggesting that the STZ treatment significantly downregulates basal PI3K signaling in striatum.
Negative_regulation (downregulates) of PI3K in striatum
9) Confidence 0.36 Published 2007 Journal PLoS Biology Section Body Doc Link PMC2020502 Disease Relevance 0.07 Pain Relevance 0.12
Collectively these data support the hypothesis that hypoinsulinemia, by downregulation of PI3K signaling (see Figure 3), significantly reduces AMPH-induced DA efflux because of reduced DAT plasma membrane expression.
Negative_regulation (downregulation) of PI3K in plasma associated with dopamine
10) Confidence 0.36 Published 2007 Journal PLoS Biology Section Body Doc Link PMC2020502 Disease Relevance 0 Pain Relevance 0.46
To address this concern, we selectively inhibited PI3K activity within the striatum of naive rats using LY294002 and then recorded AMPH-induced DA efflux in this region using HSCA.
Negative_regulation (inhibited) of PI3K in striatum associated with dopamine
11) Confidence 0.36 Published 2007 Journal PLoS Biology Section Body Doc Link PMC2020502 Disease Relevance 0 Pain Relevance 0.54
To verify whether inhibition of PI3K signaling induced by STZ treatment correlates with changes in AMPH-induced DA efflux, we used HSCA to measure the release and clearance kinetics of striatal DA in vivo [14,40].
Spec (whether) Negative_regulation (inhibition) of PI3K associated with dopamine
12) Confidence 0.36 Published 2007 Journal PLoS Biology Section Body Doc Link PMC2020502 Disease Relevance 0.07 Pain Relevance 0.18
Importantly, our data show that hypoinsulinemia reduces basal PI3K signaling and impairs the ability of AMPH to increase extracellular DA levels.
Negative_regulation (reduces) of PI3K associated with dopamine
13) Confidence 0.36 Published 2007 Journal PLoS Biology Section Body Doc Link PMC2020502 Disease Relevance 0 Pain Relevance 0.31
These data further support our hypothesis that STZ treatment, by decreasing PI3K signaling in striatum, downregulates AMPH-induced DA efflux measured by HSCA (Figures 2, 3 and 6) and fMRI (Figure 5).
Negative_regulation (decreasing) of PI3K in striatum associated with dopamine
14) Confidence 0.36 Published 2007 Journal PLoS Biology Section Body Doc Link PMC2020502 Disease Relevance 0.17 Pain Relevance 0.24
The morphine-induced enhancement was abolished by naloxone, an antagonist of mu opioid peptide receptor (MOP), wortmannin, a phosphoinositide 3-kinase (PI3K) inhibitor, and PD98059, a MEK inhibitor, but not by 1,10-phenanthroline, a metalloprotease inhibitor and U73122, a phospholipase C inhibitor.
Negative_regulation (inhibitor) of PI3K associated with antagonist, narcan, opioid and morphine
15) Confidence 0.30 Published 2005 Journal Peptides Section Abstract Doc Link 15990199 Disease Relevance 0 Pain Relevance 1.02
MOR transactivation was inhibited by LY294002, a PI3K inhibitor, and glibenclamide, a KATP channels blocker.
Negative_regulation (inhibitor) of PI3K
16) Confidence 0.29 Published 2010 Journal Mol Pain Section Body Doc Link 20540729 Disease Relevance 0 Pain Relevance 0
The PI3K inhibitor, LY-294002, was added at 50 ?
Negative_regulation (inhibitor) of PI3K
17) Confidence 0.28 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2858808 Disease Relevance 0.11 Pain Relevance 0.03
First, we treated freshly prepared primary rat hepatocytes with either Wortmannin (PI3K inhibitor), PD98059 (an ERK1/2 inhibitor), or AKTi-1/2 (an AKT kinase inhibitor).
Negative_regulation (inhibitor) of PI3K in hepatocytes
18) Confidence 0.24 Published 2010 Journal Journal of Lipid Research Section Body Doc Link PMC2903791 Disease Relevance 0.16 Pain Relevance 0.08
EffRep: 7.2 ± 0.2 AU, P < 0.05; Fig. 4c, d).Fig. 5The effect of inhibiting PI3K and Akt upon reperfusion in IPC effluent-treated recipient hearts.
Negative_regulation (inhibiting) of PI3K in hearts
19) Confidence 0.23 Published 2010 Journal Basic Res Cardiol Section Body Doc Link PMC3012213 Disease Relevance 0.19 Pain Relevance 0.09
It is important to mention that, in sepsis, many inflammatory pathways are activated in parallel with a reduction in the PI3K/Akt pathway, thus, merely blocking a single component of the inflammatory pathways or inducing the activation of PI3K may be insufficient to arrest the process.
Negative_regulation (reduction) of PI3K associated with inflammation and sepsis
20) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997789 Disease Relevance 1.26 Pain Relevance 0.28

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox