INT946

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Context Info
Confidence 0.57
First Reported 1979
Last Reported 2008
Negated 1
Speculated 4
Reported most in Abstract
Documents 60
Total Number 64
Disease Relevance 4.61
Pain Relevance 34.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Nts)
Anatomy Link Frequency
striatum 3
nucleus 2
CEA 2
nucleus accumbens 2
plasma 1
Nts (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 87 100.00 Very High Very High Very High
Dynorphin 59 100.00 Very High Very High Very High
Dopamine 56 100.00 Very High Very High Very High
Neuropeptide 32 100.00 Very High Very High Very High
Somatostatin 28 100.00 Very High Very High Very High
gABA 21 100.00 Very High Very High Very High
Substantia nigra 18 100.00 Very High Very High Very High
substance P 16 100.00 Very High Very High Very High
Rostral ventrolateral medulla 15 100.00 Very High Very High Very High
bradykinin 8 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hyperalgesia 6 99.96 Very High Very High Very High
Schizophrenia 3 99.84 Very High Very High Very High
Pain 6 99.54 Very High Very High Very High
Bardet-biedl Syndrome 5 99.40 Very High Very High Very High
Aging 1 99.40 Very High Very High Very High
Hypoxia 1 98.76 Very High Very High Very High
Functional Bowel Disorder 2 98.60 Very High Very High Very High
Diabetes Mellitus 10 97.56 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

2 97.56 Very High Very High Very High
Hypothermia 3 95.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Levels of CRH and neurotensin mRNAs were decreased on the lesioned side in the CEA and oval nucleus of the BST (BSTov) relative to the intact side and to unoperated controls.
Negative_regulation (decreased) of neurotensin in oval nucleus associated with amygdala
1) Confidence 0.57 Published 2002 Journal Brain Res. Section Abstract Doc Link 12126877 Disease Relevance 0 Pain Relevance 0.67
In the rat prefrontal cortex (PFC), neurotensin is exclusively localized to dopamine axons and has been suggested to be decreased in schizophrenia.
Negative_regulation (decreased) of neurotensin in cortex associated with dopamine and schizophrenia
2) Confidence 0.56 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 15716398 Disease Relevance 0.19 Pain Relevance 0.36
After depletion of internal Ca2+ stores by repetitive stimulation with CCH and caffeine in Ca(2+)-free buffer, reintroduction of external Ca2+ restored neurotensin inhibition of the contraction induced by CCH.
Negative_regulation (inhibition) of neurotensin in external
3) Confidence 0.55 Published 1992 Journal Am. J. Physiol. Section Abstract Doc Link 1279984 Disease Relevance 0 Pain Relevance 0.11
These results demonstrate that the inhibitory effect of neurotensin in rat ileum longitudinal muscle is apamin sensitive and cannot be observed in the presence of the Ca(2+)-channel blockers nitrendipine or verapamil.
Negative_regulation (effect) of neurotensin in longitudinal muscle
4) Confidence 0.55 Published 1992 Journal Am. J. Physiol. Section Abstract Doc Link 1279984 Disease Relevance 0 Pain Relevance 0.10
Dynorphin inhibition of the neurotensin contractile activity on the myenteric plexus.
Negative_regulation (inhibition) of neurotensin associated with dynorphin
5) Confidence 0.45 Published 1984 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 6141281 Disease Relevance 0.07 Pain Relevance 0.65
Desensitization of the neurotensin receptors antagonized the contractile activity of neurotensin.
Negative_regulation (Desensitization) of neurotensin
6) Confidence 0.43 Published 1995 Journal Eur. J. Pharmacol. Section Abstract Doc Link 7796847 Disease Relevance 0 Pain Relevance 0.16
We perfused rats intragastrically with warmed saline and stimulated acid secretion with intravenous pentagastrin, 32 micrograms/kg/hr, and found that anesthesia with pentobarbital resulted in marked inhibition of acid secretion by intravenous neurotensin; however, anesthesia with urethane prevented this inhibitory effect of neurotensin from occurring.
Negative_regulation (effect) of neurotensin associated with anesthesia
7) Confidence 0.43 Published 1991 Journal Life Sci. Section Abstract Doc Link 1671292 Disease Relevance 0 Pain Relevance 0.42
It antagonizes turning behaviour induced in mice and rats (after striatal or ventral tegmental area administration of neurotensin, respectively), hypolocomotion induced by intracerebroventricular injection of neurotensin in rats, and reverses the inhibitory effect of neurotensin (nucleus accumbens injection) on amphetamine-induced hyperlocomotion in rats.
Negative_regulation (effect) of neurotensin in nucleus accumbens associated with nucleus accumbens, ventral tegmentum and intracerebroventricular
8) Confidence 0.43 Published 1995 Journal Fundam Clin Pharmacol Section Abstract Doc Link 8808171 Disease Relevance 0.08 Pain Relevance 0.69
The present results suggest that in rat proximal colon the inhibitory action of neurotensin is largely due to production of nitric oxide (NO), likely released from neural prejunctional sites.
Negative_regulation (action) of neurotensin in neural
9) Confidence 0.43 Published 1997 Journal Am. J. Physiol. Section Abstract Doc Link 9277430 Disease Relevance 0 Pain Relevance 0.14
Anesthetic dependence of the inhibitory effect of neurotensin on pentagastrin-stimulated acid secretion in rats.
Negative_regulation (effect) of neurotensin associated with addiction
10) Confidence 0.43 Published 1991 Journal Life Sci. Section Title Doc Link 1671292 Disease Relevance 0 Pain Relevance 0.40
These actions of neurotensin are not blocked by naloxone whereas those of morphine are.
Negative_regulation (blocked) of neurotensin associated with narcan and morphine
11) Confidence 0.43 Published 1982 Journal Regul. Pept. Section Abstract Doc Link 6895946 Disease Relevance 0.17 Pain Relevance 0.49
The direct and indirect contractile response to neurotensin (100 nM) was abolished in Ca(2+)-free solution, and was antagonized by nifedipine (1-5-10 nM) and potentiated by Bay K 8644 (methyl 1,4-dihydro-2,6-dimethyl-3-nitro-4-(2-trifluoromethylphenyl)- pyridine-5-carboxylate) (10-100-1000 nM).
Negative_regulation (abolished) of neurotensin
12) Confidence 0.43 Published 1997 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9042600 Disease Relevance 0 Pain Relevance 0.08
Both SR 142948A, a non-selective neurotensin receptor type-1 and type-2 antagonist, and SR 48692, a selective type-1 receptor antagonist, blocked the depolarizing effect of neurotensin, and which themselves had no effect on membrane potential.
Negative_regulation (effect) of neurotensin associated with antagonist
13) Confidence 0.43 Published 2004 Journal Neuroscience Section Abstract Doc Link 15120846 Disease Relevance 0 Pain Relevance 0.30
Further, neurotensin was also found to block the dopamine-independent increase in locomotion and rearing produced by the injection of D-Ala2-Met- 5enkephalinamide into the nucleus accumbens.
Negative_regulation (block) of neurotensin in nucleus accumbens associated with nucleus accumbens and dopamine
14) Confidence 0.42 Published 1984 Journal Neuroscience Section Abstract Doc Link 6738859 Disease Relevance 0 Pain Relevance 1.03
Both neurotensin and norepinephrine in doses causing maximal inhibition of field-stimulated responses decreased (by 40 to 60%) contractile responses to 9 X 10(-10) mol (approximately the intra-arterial ED50 dose) of acetylcholine.
Negative_regulation (decreased) of neurotensin
15) Confidence 0.42 Published 1984 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 6329497 Disease Relevance 0 Pain Relevance 0.20
While TRH neither antagonizes opioid analgesia nor alters pain thresholds itself, it blocks neurotensin analgesia.
Negative_regulation (blocks) of neurotensin associated with pain, opioid and analgesia
16) Confidence 0.41 Published 1984 Journal Peptides Section Abstract Doc Link 6433331 Disease Relevance 0.65 Pain Relevance 1.15
In comparison to values from lesioned, vehicle-treated controls, intermittent administration of SKF 38393 reduced somatostatin and neuropeptide Y (down 61% and 57%, respectively), increased neurotensin (up 105%) and dynorphin (up 184%) and had no effect on enkephalin; continuous SKF 38393 decreased neuropeptide Y by 39% but did not alter levels of the other peptides.
Negative_regulation (reduced) of neurotensin associated with dynorphin, neuropeptide, somatostatin and enkephalin
17) Confidence 0.41 Published 1992 Journal Brain Res. Section Abstract Doc Link 1356580 Disease Relevance 0 Pain Relevance 1.16
Continuous quinpirole elevated somatostatin and neuropeptide Y levels (up 43% and 33%, respectively), but reduced the lesion-induced increases in both neurotensin (down 51%) and enkephalin (down 24%) content.
Negative_regulation (reduced) of neurotensin associated with neuropeptide, somatostatin and enkephalin
18) Confidence 0.41 Published 1992 Journal Brain Res. Section Abstract Doc Link 1356580 Disease Relevance 0 Pain Relevance 1.21
Although the inhibitory effect of norepinephrine and neurotensin was similar, the effect of neurotensin did not appear to occur by an adrenergic mechanism because alpha- and beta-receptor blockade had no effect.
Negative_regulation (effect) of neurotensin
19) Confidence 0.41 Published 1982 Journal Am. J. Physiol. Section Abstract Doc Link 7137356 Disease Relevance 0 Pain Relevance 0.17
The inhibitory effect of neurotensin on spontaneous acetylcholine- and pentagastrin-stimulated contractions was associated with a decrease in the amplitude and duration of the plateau potential of the gastric action potential.
Negative_regulation (effect) of neurotensin associated with action potential
20) Confidence 0.41 Published 1982 Journal Am. J. Physiol. Section Abstract Doc Link 7137356 Disease Relevance 0 Pain Relevance 0.17

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