INT94608

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Context Info
Confidence 0.23
First Reported 2001
Last Reported 2010
Negated 2
Speculated 2
Reported most in Body
Documents 19
Total Number 21
Disease Relevance 8.06
Pain Relevance 6.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell morphogenesis (P2rx7) mitochondrion organization (P2rx7) protein complex (P2rx7)
transmembrane transport (P2rx7) cytoplasm (P2rx7) cell death (P2rx7)
Anatomy Link Frequency
neurons 4
microglia 2
neuronal 1
leukocyte 1
spinal cord 1
P2rx7 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 182 100.00 Very High Very High Very High
agonist 136 100.00 Very High Very High Very High
excitatory amino acid 14 100.00 Very High Very High Very High
Pain 53 99.86 Very High Very High Very High
Inflammation 56 99.68 Very High Very High Very High
Glutamate 159 99.34 Very High Very High Very High
Hyperalgesia 9 99.22 Very High Very High Very High
Nucleus accumbens 152 98.76 Very High Very High Very High
Eae 48 98.52 Very High Very High Very High
Ventral tegmentum 36 98.04 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 70 99.86 Very High Very High Very High
INFLAMMATION 61 99.68 Very High Very High Very High
Injury 188 99.60 Very High Very High Very High
Status Epilepticus 106 99.36 Very High Very High Very High
Hyperalgesia 13 99.22 Very High Very High Very High
Neuropathic Pain 127 97.68 Very High Very High Very High
Apoptosis 107 97.60 Very High Very High Very High
Cv Unclassified Under Development 18 96.92 Very High Very High Very High
Demyelinating Disease 4 95.56 Very High Very High Very High
Motor Neuron Diseases 4 94.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
An up-regulation of P2X7-IR after injury suggests involvement of this receptor subtype in apoptotic rather than in proliferative events.



Regulation (regulation) of P2X7 associated with injury and apoptosis
1) Confidence 0.23 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072928 Disease Relevance 0.93 Pain Relevance 0.03
Modulation of P2X7 receptors in non-neuronal cells might have impact on peripheral sensory transduction under normal and pathological states.
Regulation (Modulation) of P2X7 in neuronal
2) Confidence 0.20 Published 2005 Journal Brain Res. Section Abstract Doc Link 16005856 Disease Relevance 0 Pain Relevance 0.11
Up-regulation of microglial P2X7 receptors has been observed in several pathological models, such as in vivo ischemia [41, 44, 45], as well as multiple sclerosis and amyotrophic lateral sclerosis of the human spinal cord [46].
Regulation (regulation) of P2X7 in spinal cord associated with multiple sclerosis, ischemia, motor neuron diseases and spinal cord
3) Confidence 0.20 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072928 Disease Relevance 0.93 Pain Relevance 0.30
A possible influence of P2X7 receptor stimulation on the increase in cell number of activated and ramified microglial cells after BzATP stimulation was also studied.
Spec (possible) Regulation (influence) of P2X7 in microglial cells
4) Confidence 0.20 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072928 Disease Relevance 0.39 Pain Relevance 0.07
The involvement of endogenous ATP in the development of TMJ inflammatory hyperalgesia was also determined by evaluating the effect of the general P2 receptor antagonist pyridoxal-phosphate-6-azophenyl-2',4'-disulphonic acid (PPADS) on carrageenan-induced TMJ inflammatory hyperalgesia.
Regulation (effect) of P2 receptor associated with hyperalgesia, inflammation and antagonist
5) Confidence 0.19 Published 2005 Journal Eur J Pain Section Abstract Doc Link 15629879 Disease Relevance 1.01 Pain Relevance 0.88
No anti-P2X7 immunoreactivity was observed on DRG neurons.
Regulation (immunoreactivity) of P2X7 in neurons
6) Confidence 0.17 Published 2005 Journal Brain Res. Section Abstract Doc Link 16005856 Disease Relevance 0.06 Pain Relevance 0.18
In addition, P2X7 receptor-mediated MCP-1 (released from microglia)/MIP-2 (released from astrocytes) regulation was related to SE-induced leukocyte infiltration in an IL-1?
Regulation (regulation) of P2X7 in leukocyte associated with status epilepticus
7) Confidence 0.14 Published 2010 Journal J Neuroinflammation Section Abstract Doc Link PMC2964655 Disease Relevance 0.63 Pain Relevance 0.12
Selective P2X7 receptor antagonists for chronic inflammation and pain

ATP, acting on P2X7 receptors, stimulates changes in intracellular calcium concentrations, maturation, and release of interleukin-1?

Regulation (acting) of P2X7 associated with pain, inflammation and antagonist
8) Confidence 0.14 Published 2008 Journal Purinergic Signal Section Title Doc Link PMC2721772 Disease Relevance 0.70 Pain Relevance 0.59
Inflammation was assessed by, histological evaluation, macroscopic damage score, myeloperoxidase (MPO) activity, and substance P receptor immunoreactivity (SPRIR).
Regulation (immunoreactivity) of P receptor
9) Confidence 0.13 Published 2009 Journal Hepatogastroenterology Section Body Doc Link 19621680 Disease Relevance 0.09 Pain Relevance 0
The up-regulation of P2X7-IR after injury suggests that this receptor is involved in apoptotic rather than proliferative effects.



Regulation (regulation) of P2X7 associated with injury and apoptosis
10) Confidence 0.12 Published 2007 Journal Purinergic Signal Section Abstract Doc Link PMC2072928 Disease Relevance 0.58 Pain Relevance 0.19
Microglia also express another subtype of P2X, P2X7, but this receptor subtype appears not to be involved because activation of P2X7 typically requires a higher concentration of ATP than used [55, 56] and because TNP-ATP, which does not affect P2X7 [57], prevents ATP from stimulating microglia to produce allodynia.
Neg (not) Regulation (affect) of P2X7 in microglia associated with allodynia
11) Confidence 0.09 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096756 Disease Relevance 0.98 Pain Relevance 0.82
The different pathways in the P2 receptor-mediated regulation of the finally expressed pattern of locomotor activity caused by endogenous or exogenous stimuli may have consequences for feeding behavior.
Regulation (regulation) of P2 receptor associated with eae
12) Confidence 0.09 Published 2004 Journal Purinergic Signal Section Body Doc Link PMC2096569 Disease Relevance 0.09 Pain Relevance 0.34
In relation to this, P2X7 receptors are responsible for BDNF release from Schwann cells, which display neuroprotective actions on neighbouring vestibular neurons [32].
Regulation (responsible) of P2X7 in neurons
13) Confidence 0.08 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2858808 Disease Relevance 0.08 Pain Relevance 0.15
In granule neurons, the protein Bax has been described to be phosphorylated by GSK3, and this could be one possible target for P2X7 receptors [15].
Regulation (target) of P2X7 in neurons
14) Confidence 0.08 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2858808 Disease Relevance 0.18 Pain Relevance 0.03
Recent studies have further investigated the intracellular signalling mechanisms triggered by nucleotide receptors and have demonstrated the coupling of P2Y13 and P2X7 receptors to GSK3 phosphorylation in rat cerebellar granule neurons.
Regulation (coupling) of P2X7 in neurons
15) Confidence 0.08 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2858808 Disease Relevance 0 Pain Relevance 0.05
Therefore, P2 receptor agonists and antagonists acting on most of the purinergic receptor subtypes are widely used in experimental approaches to study biological functions of these receptors.
Regulation (acting) of P2 receptor associated with antagonist and agonist
16) Confidence 0.08 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072925 Disease Relevance 0.13 Pain Relevance 0.25
Therefore, P2 receptor agonists may modulate the activity of dopaminergic cell bodies in the VTA both by local direct stimulation and/or indirect inhibitory control via dopamine release and subsequent dopamine D2 receptor stimulation in the NAc.
Spec (may) Regulation (modulate) of P2 receptor associated with nucleus accumbens, ventral tegmentum, dopamine and agonist
17) Confidence 0.07 Published 2004 Journal Purinergic Signal Section Body Doc Link PMC2096569 Disease Relevance 0 Pain Relevance 0.71
By contrast, the mRNA levels of P2X7 and P2Y12 receptors were not changed.
Neg (not) Regulation (changed) of P2X7
18) Confidence 0.05 Published 2009 Journal Mol Pain Section Body Doc Link PMC2690582 Disease Relevance 0.50 Pain Relevance 0.77
As a final test of the respective roles of glutamate and ATP release in the NTS, the effects of EAA and P2 receptor antagonists on firing of the second order relay pump neurones were examined (Fig. 8).
Regulation (effects) of P2 receptor associated with glutamate, antagonist and excitatory amino acid
19) Confidence 0.03 Published 2008 Journal The Journal of Physiology Section Body Doc Link PMC2538935 Disease Relevance 0.17 Pain Relevance 0.20
Zopiclone exerts its action by binding on the benzodiazepine receptor complex[1] and modulation of the GABAB Z receptor chloride channel macromolecular complex.
Regulation (modulation) of GABAB Z receptor
20) Confidence 0.02 Published 2010 Journal Journal of Young Pharmacists : JYP Section Body Doc Link PMC2964772 Disease Relevance 0.47 Pain Relevance 0.15

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