INT94614

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Context Info
Confidence 0.35
First Reported 2001
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 2.54
Pain Relevance 1.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (PTGER3) cell death (PTGER3) plasma membrane (PTGER3)
biological_process (PTGER3) signal transducer activity (PTGER3)
Anatomy Link Frequency
colon 1
afferent neurons 1
PTGER3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Spinal cord 9 98.16 Very High Very High Very High
Intracerebroventricular 3 98.00 Very High Very High Very High
intrathecal 3 96.92 Very High Very High Very High
Inflammation 14 96.48 Very High Very High Very High
cINOD 12 92.40 High High
imagery 1 88.24 High High
antinociception 1 88.04 High High
analgesia 1 87.24 High High
antagonist 13 85.84 High High
agonist 28 85.12 High High
Disease Link Frequency Relevance Heat
Colon Cancer 65 98.84 Very High Very High Very High
Cancer 25 96.48 Very High Very High Very High
INFLAMMATION 24 96.48 Very High Very High Very High
Uterine Fibroids 72 95.84 Very High Very High Very High
Frailty 1 94.00 High High
Disease 8 88.68 High High
Rheumatoid Arthritis 23 78.00 Quite High
Overactive Bladder 4 75.00 Quite High
Nociception 6 71.20 Quite High
Neuroblastoma 3 69.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both DG041 and CM9 showed a high affinity for EP3 receptors at subnanomolar concentrations without significant selectivity for any splice variants.
EP3 Binding (affinity) of
1) Confidence 0.35 Published 2008 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 18632791 Disease Relevance 0.14 Pain Relevance 0.48
According to such a scenario, and within the context of colon cancerogenesis, PGE2 signalling via EP3 could be a priming step for CRC cell mitogenesis that becomes shut off at later time points as aberrant proliferation takes over.


EP3 Binding (signalling) of in colon associated with colon cancer
2) Confidence 0.24 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2615781 Disease Relevance 0.56 Pain Relevance 0.03
R2 and PTGER3 and the complex interplay among five distinct nuclear receptors (ER, RAR, RXR, NR4A1 and PPAR?)
PTGER3 Binding (interplay) of
3) Confidence 0.22 Published 2007 Journal BMC Womens Health Section Body Doc Link PMC1852551 Disease Relevance 1.49 Pain Relevance 0
Five genes from maternal data (CRHBP, FV, IL-5, tPA, and PTGER3) and three in fetal data (CBS, IL-10RA, and TREM1) that showed highly significant associations with PTB were analyzed for haplotype association.
PTGER3 Binding (associations) of
4) Confidence 0.21 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2553267 Disease Relevance 0 Pain Relevance 0
Two non-overlapping haplotypes were associated in PTGER3, rs977214-rs6665776-rs594454 and rs2050066-6424414-rs2300167 both located in intronic regions.
PTGER3 Binding (associated) of
5) Confidence 0.21 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2553267 Disease Relevance 0 Pain Relevance 0
Five genes from maternal data (CRHBP, FV, IL-5, tPA, and PTGER3) and three in fetal data (CBS, IL-10RA, and TREM1) that showed highly significant associations with PTB were analyzed for haplotype association.
PTGER3 Spec (analyzed) Binding (association) of
6) Confidence 0.21 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2553267 Disease Relevance 0 Pain Relevance 0
Only recently, human prostaglandin E synthase (PGE-S) has been identified and cloned as a membrane bound, microsomal, glutathione-dependent inducible enzyme.
PGE-S Binding (bound) of
7) Confidence 0.19 Published 2002 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 12512699 Disease Relevance 0 Pain Relevance 0.08
Prostaglandins then bind to G-protein-coupled receptors located in intrinsic spinal neurons (receptor types DP and EP2) and primary afferent neurons (EP1, EP3, EP4 and IP).
EP3 Binding (bind) of in afferent neurons
8) Confidence 0.02 Published 2001 Journal Prog. Neurobiol. Section Abstract Doc Link 11275357 Disease Relevance 0.35 Pain Relevance 0.99

General Comments

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