INT94623

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Context Info
Confidence 0.62
First Reported 2001
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.17
Pain Relevance 2.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (ADAM18)
Anatomy Link Frequency
neuronal 1
ADAM18 (Homo sapiens)
ADAM18 - L858F (1)
Pain Link Frequency Relevance Heat
Nav1.7 98 99.90 Very High Very High Very High
qutenza 13 99.84 Very High Very High Very High
Pain 25 97.08 Very High Very High Very High
Pain threshold 1 95.92 Very High Very High Very High
addiction 6 92.44 High High
peripheral neuropathy 1 55.64 Quite High
Quantitative sensory testing 1 50.56 Quite High
sodium channel 10 50.00 Quite Low
dorsal root ganglion 10 5.00 Very Low Very Low Very Low
nav1.8 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pain 26 97.08 Very High Very High Very High
Neuropathic Pain 2 68.64 Quite High
Peripheral Neuropathy 1 55.64 Quite High
Erythermalgia 27 50.00 Quite Low
Ganglion Cysts 12 5.00 Very Low Very Low Very Low
Complex Regional Pain Syndromes 2 5.00 Very Low Very Low Very Low
Nociception 2 5.00 Very Low Very Low Very Low
Disease 2 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 2 5.00 Very Low Very Low Very Low
Myotonic Disorders 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Skin biopsies were obtained and were processed for immunohistochemical localization of (ENFs) using the pan neuronal marker protein gene product 9.5.
Localization (localization) of neuronal marker protein gene product 9.5 in neuronal
1) Confidence 0.62 Published 2001 Journal Pain Section Abstract Doc Link 11275380 Disease Relevance 1.17 Pain Relevance 2.00
Thus for both WT and L858F, the sensitivity of the channels to small voltage changes close to the midpoint of activation is decreased at low temperatures.


Localization (decreased) of L858F (L858F) associated with nav1.7
2) Confidence 0.00 Published 2007 Journal Mol Pain Section Body Doc Link PMC1781932 Disease Relevance 0 Pain Relevance 0.94

General Comments

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