INT94628

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Context Info
Confidence 0.75
First Reported 2001
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 12
Total Number 12
Disease Relevance 5.58
Pain Relevance 2.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (CD1D) histone binding (CD1D) plasma membrane (CD1D)
cytoplasm (CD1D)
Anatomy Link Frequency
lymph node 1
GBM 1
crest 1
CD1D (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 148 100.00 Very High Very High Very High
unmyelinated 2 99.42 Very High Very High Very High
Pain 4 95.84 Very High Very High Very High
headache 2 94.00 High High
anesthesia 6 93.44 High High
Pain threshold 6 90.44 High High
cINOD 1 82.40 Quite High
abdominal pain 1 82.12 Quite High
dexamethasone 10 79.76 Quite High
Inflammation 30 77.88 Quite High
Disease Link Frequency Relevance Heat
Glioblastoma 38 99.82 Very High Very High Very High
Nociception 8 99.42 Very High Very High Very High
Langerhans-cell Histiocytosis 7 98.68 Very High Very High Very High
Interdigitating Dendritic Cell Sarcoma 7 98.14 Very High Very High Very High
Histiocytosis 1 96.84 Very High Very High Very High
Pain 9 95.84 Very High Very High Very High
Papular Skin Disease 1 94.08 High High
Headache 2 94.00 High High
Eosinophilic Granuloma 1 93.92 High High
Diabetes Insipidus 1 93.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
An iliac crest bone biopsy showed an eosinophil-rich infiltrate admixed with histiocytoid cells with reniform nuclei, which expressed S100 and CD1a, consistent with a diagnosis of LCH.
Gene_expression (expressed) of CD1a in crest associated with langerhans-cell histiocytosis
1) Confidence 0.75 Published 2008 Journal J. Cutan. Pathol. Section Abstract Doc Link 18840155 Disease Relevance 1.05 Pain Relevance 0.09
Definitive diagnosis is made by histopathology including immunohistochemical detection of S-100, HLA-DR and CD1a antigens.
Gene_expression (detection) of CD1a
2) Confidence 0.75 Published 2008 Journal Neurocirugia (Astur) Section Abstract Doc Link 18936863 Disease Relevance 0.45 Pain Relevance 0.19
Cutaneous A beta fibers and nociceptive A delta fibers, but not unmyelinated C fibers, contribute to the generation of the electrically evoked R3 component.
Gene_expression (generation) of R3 associated with nociception and unmyelinated
3) Confidence 0.52 Published 2001 Journal Pain Section Abstract Doc Link 11275397 Disease Relevance 0.56 Pain Relevance 0.62
This study was conducted to investigate the contribution of nociceptive A delta and C fibers to the generation of the electrically evoked R3 blink reflex.
Gene_expression (generation) of R3 associated with nociception
4) Confidence 0.52 Published 2001 Journal Pain Section Abstract Doc Link 11275397 Disease Relevance 0.47 Pain Relevance 0.45
Morphologic and cytochemical analysis of biopsies from the abdominal mass and inguinal node were consistent with a diagnosis of IDCS, and immunohistochemical stains of the lymph node were positive for CLA, Kp-1, S-100, while negative for CD1a, CD3, CD20, CKER, and HMB45.
Neg (negative) Gene_expression (negative) of CD1a in lymph node associated with interdigitating dendritic cell sarcoma
5) Confidence 0.26 Published 2002 Journal Leuk. Lymphoma Section Abstract Doc Link 12153170 Disease Relevance 1.16 Pain Relevance 0.08
However, these unusual CD4+ CD56+ cells, preferentially found in GBM, do not express CD1d or V?
Neg (not) Gene_expression (express) of CD1d in GBM associated with glioblastoma
6) Confidence 0.23 Published 2010 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2952949 Disease Relevance 1.00 Pain Relevance 0
The R3 and G4 open reading frames
Gene_expression (The) of R3
7) Confidence 0.12 Published 2007 Journal Retrovirology Section Body Doc Link PMC1839114 Disease Relevance 0.07 Pain Relevance 0
Similar conclusions were drawn from HTLV mutant proviruses deleted in the ORFs encoding the p12I and p13II/p30II orthologs of R3 and G4 [240-242].
Gene_expression (encoding) of R3
8) Confidence 0.12 Published 2007 Journal Retrovirology Section Body Doc Link PMC1839114 Disease Relevance 0.28 Pain Relevance 0
The response of HMC-1 cells to the stimulant calcium ionophore was investigated to assess the releasability of HMC-1 cells. 0.25?
Gene_expression (cells.) of HMC-1
9) Confidence 0.05 Published 2004 Journal BMC Pharmacol Section Body Doc Link PMC526189 Disease Relevance 0 Pain Relevance 0.12
Intracellular Ca(2+) triggered the activation of mitogen-activated protein kinase (MAPK) in HMC-1, especially p42 and p44 isoforms of extracellular signal-regulated kinase (ERK) and p38 MAPK, but not c-Jun N-terminal kinase (JNK).
Gene_expression (isoforms) of HMC-1
10) Confidence 0.04 Published 2005 Journal Cytokine Section Abstract Doc Link 16343928 Disease Relevance 0.16 Pain Relevance 0.20
significantly induced production of these cytokines in HMC-1, while epinephrine alone did not.
Gene_expression (production) of HMC-1 associated with cytokine
11) Confidence 0.01 Published 2004 Journal BMC Immunol Section Abstract Doc Link PMC521685 Disease Relevance 0.38 Pain Relevance 0.37
Plasmid DNA was obtained with double-cesium chloride purification (BioServe Biotechnologies, Laurel, MD), while SuperFect reagent (Qiagen) was used for transient transfections of HMC-1 cells.
Gene_expression (transfections) of HMC-1
12) Confidence 0.01 Published 2004 Journal BMC Immunol Section Body Doc Link PMC521685 Disease Relevance 0 Pain Relevance 0

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