INT94630

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Context Info
Confidence 0.03
First Reported 2001
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.10
Pain Relevance 1.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Adarb1, Fos) nucleus (Adarb1, Fos) nucleoplasm (Adarb1)
aging (Fos) mRNA processing (Adarb1) RNA binding (Adarb1)
Anatomy Link Frequency
forebrain 2
lateral 1
Adarb1 (Rattus norvegicus)
Fos (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 7 100.00 Very High Very High Very High
parabrachial 4 100.00 Very High Very High Very High
mu opioid receptor 2 100.00 Very High Very High Very High
nMDA receptor 2 100.00 Very High Very High Very High
Neuronal nitric oxide synthase 1 93.44 High High
Glutamate receptor 1 89.12 High High
agonist 1 88.04 High High
Enkephalin 1 86.60 High High
antagonist 2 86.52 High High
cerebral cortex 1 68.32 Quite High
Disease Link Frequency Relevance Heat
Cognitive Disorder 2 97.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Activating mu-opioid receptors in the lateral parabrachial nucleus increases c-Fos expression in forebrain areas associated with caloric regulation, reward and cognition.
Positive_regulation (Activating) of receptors in lateral Positive_regulation (increases) of Gene_expression (expression) of c-Fos in forebrain associated with cognitive disorder, mu opioid receptor and parabrachial
1) Confidence 0.03 Published 2009 Journal Neuroscience Section Title Doc Link 19422884 Disease Relevance 0.10 Pain Relevance 0.50
Because activation of NMDA receptors mediates morphine-induced c-Fos expression, we tested the hypothesis that activation of nNOS is involved in this cascade.
Positive_regulation (activation) of receptors Positive_regulation (mediates) of Gene_expression (expression) of c-Fos associated with nmda receptor and morphine
2) Confidence 0.02 Published 2001 Journal Brain Res. Bull. Section Abstract Doc Link 11275410 Disease Relevance 0 Pain Relevance 0.83

General Comments

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