INT94649

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Context Info
Confidence 0.77
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 19
Total Number 20
Disease Relevance 5.11
Pain Relevance 6.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Grm1) plasma membrane (Grm1) nucleus (Grm1)
signal transducer activity (Grm1)
Anatomy Link Frequency
striatum 2
T cells 2
retina 1
VPL 1
prefrontal 1
Grm1 (Mus musculus)
Pain Link Frequency Relevance Heat
Pyramidal cell 41 100.00 Very High Very High Very High
Glutamate receptor 39 100.00 Very High Very High Very High
antagonist 14 100.00 Very High Very High Very High
Glutamate 16 99.84 Very High Very High Very High
analgesia 4 99.54 Very High Very High Very High
Thalamus 45 99.52 Very High Very High Very High
Hippocampus 10 99.40 Very High Very High Very High
projection neuron 2 99.28 Very High Very High Very High
Central nervous system 5 99.00 Very High Very High Very High
Spinal cord 7 98.58 Very High Very High Very High
Disease Link Frequency Relevance Heat
Retina Disease 144 100.00 Very High Very High Very High
Cognitive Disorder 44 99.10 Very High Very High Very High
Targeted Disruption 294 98.86 Very High Very High Very High
Ganglion Cysts 23 98.24 Very High Very High Very High
Pain 15 97.80 Very High Very High Very High
INFLAMMATION 12 97.24 Very High Very High Very High
Neurological Disease 6 96.24 Very High Very High Very High
Sprains And Strains 4 95.68 Very High Very High Very High
Hyperalgesia 5 92.92 High High
Nociception 12 89.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Metabotropic glutamate receptor 1 (mGluR1) is expressed in the dendrites of M/T cells and is thought to participate in intraglomerular interactions among M/T cells.
Gene_expression (expressed) of mGluR1 in T cells associated with glutamate receptor
1) Confidence 0.77 Published 2009 Journal J. Neurophysiol. Section Abstract Doc Link 19164106 Disease Relevance 0 Pain Relevance 0.17
Metabotropic glutamate receptor 1 (mGluR1) is expressed in the dendrites of M/T cells and is thought to participate in intraglomerular interactions among M/T cells.
Gene_expression (expressed) of Metabotropic glutamate receptor 1 in T cells associated with glutamate receptor
2) Confidence 0.77 Published 2009 Journal J. Neurophysiol. Section Abstract Doc Link 19164106 Disease Relevance 0 Pain Relevance 0.17
In contrast, small prefrontal boutons formed synapses mainly with PV+ thalamic projection neurons with metabotropic glutamate receptors, mGluR1a (Fig. 11, m1).
Gene_expression (projection neurons) of mGluR1 in prefrontal associated with glutamate receptor and pyramidal cell
3) Confidence 0.65 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1952177 Disease Relevance 0 Pain Relevance 0.30
Here we report the presence of phospholipase C-coupled group I mGluRs (mGluR1 and mGluR5) outside the central nervous system on peripheral unmyelinated sensory afferents.
Gene_expression (presence) of mGluR1 in central nervous system associated with central nervous system and unmyelinated
4) Confidence 0.65 Published 2001 Journal Nat. Neurosci. Section Abstract Doc Link 11276233 Disease Relevance 0.38 Pain Relevance 0.54
Finally, Vim mRNA is expressed at a roughly similar level, while significantly fewer cFos, Slc1a3, and Grm1 transcripts are expressed in the WT mouse retina.
Gene_expression (expressed) of Grm1 in retina
5) Confidence 0.64 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2719914 Disease Relevance 0.07 Pain Relevance 0
We also measured the expression levels (Figure 4C) of six genes in addition to Clrn1 and Thy1: cFos, Slc1a3, Grm1, Rho, Rp1, and Vim.
Gene_expression (expression) of Grm1
6) Confidence 0.64 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2719914 Disease Relevance 0.10 Pain Relevance 0.04
When compared to expression levels in the WT animal, the loss of photoreceptors resulted in reduced expression of the immediate early gene transcription factor cFos, as well as Slc1a3 and Grm1, a glutamate transporter and receptor, respectively.
Gene_expression (expression) of Grm1 in photoreceptors associated with glutamate
7) Confidence 0.64 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2719914 Disease Relevance 0.09 Pain Relevance 0.05
For quantitative gene expression in animal models of retinal degeneration (C3H mice, RCS and P23H-3 rats), SYBR green was the reporter molecule used to assess expression of several retinal transcripts: cFos, Slc1a3, Grm1, Rhod, Rp-1, Thy1, Clrn1, and Vim.
Gene_expression (expression) of Grm1 associated with retina disease
8) Confidence 0.50 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2719914 Disease Relevance 0.20 Pain Relevance 0.04
Metabotropic glutamate receptor 1 (mGluR1) is highly expressed in striatonigral projection neurons of rat striatum.
Gene_expression (expressed) of Metabotropic glutamate receptor 1 in striatum associated with glutamate receptor and projection neuron
9) Confidence 0.31 Published 2002 Journal Synapse Section Abstract Doc Link 11891880 Disease Relevance 0 Pain Relevance 0.37
Metabotropic glutamate receptor 1 (mGluR1) is highly expressed in striatonigral projection neurons of rat striatum.
Gene_expression (expressed) of mGluR1 in striatum associated with glutamate receptor and projection neuron
10) Confidence 0.31 Published 2002 Journal Synapse Section Abstract Doc Link 11891880 Disease Relevance 0 Pain Relevance 0.37
The mouse thalamus also has been shown to express a high level of metabotropic glutamate receptor type 1 (mGluR1), which stimulates PLCbetas through activation of Galphaq/11 protein.
Gene_expression (express) of mGluR1 in thalamus associated with glutamate receptor and thalamus
11) Confidence 0.10 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 12954872 Disease Relevance 0.66 Pain Relevance 0.46
Two other pathways, the Metabotropic glutamate receptor group I pathway and the Muscarinic acetylcholine receptor 1 and 3 signaling pathway, related with Glutamate, are also present.
Gene_expression (pathway) of Metabotropic glutamate receptor group I associated with glutamate and glutamate receptor
12) Confidence 0.09 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2708922 Disease Relevance 0.38 Pain Relevance 0.23
In contrast, PLCbeta4 knock-out mice did not show such enhancement, indicating that mGluR1 is connected to PLCbeta4 in the VPL.
Gene_expression (connected) of mGluR1 in VPL associated with targeted disruption
13) Confidence 0.09 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 12954872 Disease Relevance 1.15 Pain Relevance 0.86
Moreover, mGluR1-rescue mice, which express the metabotropic glutamate receptor-subtype 1 (mGluR1) only in Purkinje cells (PCs) of their cerebellum are incapable of accomplishing an object recognition test [31], indicating that other structures expressing the mGluR1 (probably the hippocampus) are necessary for the accomplishment of this long-term memory test.


Gene_expression (express) of mGluR1 in Purkinje cells associated with cognitive disorder, glutamate receptor and hippocampus
14) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920824 Disease Relevance 0.26 Pain Relevance 0.14
Moreover, mGluR1-rescue mice, which express the metabotropic glutamate receptor-subtype 1 (mGluR1) only in Purkinje cells (PCs) of their cerebellum are incapable of accomplishing an object recognition test [31], indicating that other structures expressing the mGluR1 (probably the hippocampus) are necessary for the accomplishment of this long-term memory test.


Gene_expression (expressing) of mGluR1 in hippocampus associated with cognitive disorder, glutamate receptor and hippocampus
15) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920824 Disease Relevance 0.25 Pain Relevance 0.17
In conclusion, YM-298198 is a newly synthesized, high-affinity, selective, and noncompetitive antagonist of mGluR1 that will be a useful pharmacological tool due to its highly active properties in vitro and in vivo.
Gene_expression (synthesized) of mGluR1 associated with antagonist
16) Confidence 0.04 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15976016 Disease Relevance 0.09 Pain Relevance 0.47
Here, we describe the radioligand binding properties and pharmacological effects of a newly synthesized, high-affinity, selective, and noncompetitive mGluR1 antagonist, 6-amino-N-cyclohexyl-N,3-dimethylthiazolo[3,2-a]benzimidazole-2-carboxamide (YM-298198).
Gene_expression (synthesized) of mGluR1 associated with antagonist
17) Confidence 0.04 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15976016 Disease Relevance 0.10 Pain Relevance 0.25
We demonstrated previously that the group I metabotropic glutamate receptors (mGluRs) mGlu1 and mGlu5 are expressed in the peripheral terminals of sensory neurons and that activation of group I mGluRs in the skin increases thermal sensitivity.
Gene_expression (expressed) of mGlu1 in skin associated with glutamate receptor
18) Confidence 0.00 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12196566 Disease Relevance 0.17 Pain Relevance 0.49
Both MS-275 and SAHA up-regulated the expression of mGlu2 receptors in the dorsal root ganglion (DRG) and spinal cord under conditions in which they caused analgesia, without changing the expression of mGlu1a, mGlu4, or mGlu5 receptors.
Gene_expression (expression) of mGlu1a in dorsal root ganglion associated with ganglion cysts, dorsal root ganglion, analgesia and spinal cord
19) Confidence 0.00 Published 2009 Journal Mol. Pharmacol. Section Abstract Doc Link 19255242 Disease Relevance 0.65 Pain Relevance 0.91
This potentiation is not associated with increased mGlu1 or mGlu5 receptor expression but is associated with increased levels of phosphorylated ERK in dorsal horn neurons.
Gene_expression (expression) of mGlu1 in neurons associated with dorsal horn neuron
20) Confidence 0.00 Published 2004 Journal Pain Section Abstract Doc Link 15327816 Disease Relevance 0.56 Pain Relevance 0.57

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