INT94650

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Context Info
Confidence 0.77
First Reported 2001
Last Reported 2010
Negated 4
Speculated 0
Reported most in Body
Documents 32
Total Number 38
Disease Relevance 11.26
Pain Relevance 14.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Grm5) plasma membrane (Grm5) cytoplasm (Grm5)
signal transducer activity (Grm5)
Anatomy Link Frequency
oocytes 3
face 3
central nervous system 2
astrocytes 2
spinal nerve 1
Grm5 (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate receptor 112 100.00 Very High Very High Very High
Calcium channel 74 99.84 Very High Very High Very High
allodynia 10 99.84 Very High Very High Very High
Sciatic nerve 11 99.80 Very High Very High Very High
Pain 108 99.62 Very High Very High Very High
Central nervous system 28 99.44 Very High Very High Very High
amygdala 14 99.44 Very High Very High Very High
Pyramidal cell 166 99.34 Very High Very High Very High
IPN 10 99.28 Very High Very High Very High
Eae 109 99.12 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nervous System Injury 19 99.96 Very High Very High Very High
Neuropathic Pain 29 99.84 Very High Very High Very High
Inflammatory Pain 10 99.28 Very High Very High Very High
Anxiety Disorder 143 99.24 Very High Very High Very High
Pain 140 99.08 Very High Very High Very High
Targeted Disruption 290 98.94 Very High Very High Very High
Nociception 24 98.84 Very High Very High Very High
Depression 270 98.64 Very High Very High Very High
Alcohol Addiction 7 98.26 Very High Very High Very High
Hyperalgesia 28 98.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here we report the presence of phospholipase C-coupled group I mGluRs (mGluR1 and mGluR5) outside the central nervous system on peripheral unmyelinated sensory afferents.
Gene_expression (presence) of mGluR5 in central nervous system associated with central nervous system and unmyelinated
1) Confidence 0.77 Published 2001 Journal Nat. Neurosci. Section Abstract Doc Link 11276233 Disease Relevance 0.38 Pain Relevance 0.54
It should also be noted that coexpression of CaM with mGluR5a in the absence of Siah1a yields no changes in calcium current modulation (data not shown).
Gene_expression (coexpression) of mGluR5
2) Confidence 0.75 Published 2001 Journal BMC Neurosci Section Body Doc Link PMC58838 Disease Relevance 0 Pain Relevance 0
In cells expressing mGluR5a and GFP-Siah1a-CT, inhibition was reduced to 14 ± 3 (n = 6; p < 0.05; figure 5B).
Gene_expression (expressing) of mGluR5
3) Confidence 0.75 Published 2001 Journal BMC Neurosci Section Body Doc Link PMC58838 Disease Relevance 0.05 Pain Relevance 0.09
The metabotropic glutamate receptor subtype 5 (mGluR5) has been implicated in anxiety, depression, pain, mental retardation, and addiction.
Gene_expression (metabotropic) of mGluR5 associated with addiction, pain, intellectual impairment, depression, glutamate receptor and anxiety disorder
4) Confidence 0.67 Published 2009 Journal J. Med. Chem. Section Abstract Doc Link 19445453 Disease Relevance 0.39 Pain Relevance 0.40
As with mGluR5b, mGluR5a produced a rapid and reversible calcium current inhibition when 100 ?
Gene_expression (produced) of mGluR5
5) Confidence 0.65 Published 2001 Journal BMC Neurosci Section Body Doc Link PMC58838 Disease Relevance 0.07 Pain Relevance 0.09
Double-labeling experiments showed that the increased mGluR5 was predominantly expressed in the neurons and sparsely expressed in the processes of astrocytes following repeated treatment with morphine.
Gene_expression (expressed) of mGluR5 in astrocytes associated with morphine
6) Confidence 0.61 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 16000152 Disease Relevance 0 Pain Relevance 1.66
Double-labeling experiments showed that the increased mGluR5 was predominantly expressed in the neurons and sparsely expressed in the processes of astrocytes following repeated treatment with morphine.
Gene_expression (expressed) of mGluR5 in astrocytes associated with morphine
7) Confidence 0.61 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 16000152 Disease Relevance 0 Pain Relevance 1.64
The underlying cause for our findings is unclear, but altered OSS behavior in both mGluR5 KO and Het mice suggests that even subtle variation in mGluR5 expression is capable of altering reinforcement behavior in this paradigm.
Gene_expression (expression) of mGluR5 associated with targeted disruption
8) Confidence 0.60 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2994905 Disease Relevance 0.57 Pain Relevance 0.29
To determine if altered mGluR5 expression levels also affected locomotor activity relevant to OSS, we tested locomotor activity in a novel environment and after habituation.
Gene_expression (expression) of mGluR5 associated with eae
9) Confidence 0.60 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2994905 Disease Relevance 0.12 Pain Relevance 0.41
Recent studies have indicated that metabotropic glutamate receptors mGluR5, mGluR2/3 and mGluR7 are present in the regions of central nervous system important for nociceptive transmission, but their involvement in neuropathic pain has not been well established.
Gene_expression (present) of mGluR5 in central nervous system associated with nociception, glutamate receptor, neuropathic pain and central nervous system
10) Confidence 0.58 Published 2008 Journal Pain Section Abstract Doc Link 18442882 Disease Relevance 0.70 Pain Relevance 1.00
Thus, spinal administration of selective agonists such as dihydroxy phenyl glycine produced allodynia, while mGluR5 was shown to be significantly over-expressed in some, but not all, chronic pain models [91].
Neg (not) Gene_expression (expressed) of mGluR5 in spinal associated with allodynia, lasting pain and agonist
11) Confidence 0.58 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206352 Disease Relevance 1.12 Pain Relevance 1.03
Cells expressing an extracellularly myc-tagged mGluR5a (mGluR5a-myc) exhibited calcium current inhibition of 42 ± 4% (n = 6) upon glutamate application.
Gene_expression (expressing) of mGluR5 associated with glutamate
12) Confidence 0.58 Published 2001 Journal BMC Neurosci Section Body Doc Link PMC58838 Disease Relevance 0 Pain Relevance 0.26
Analysis of FR-1 operant responding for food reinforcer revealed no significant effect of mGluR5 genotype on either active (F(2,91)?
Gene_expression (genotype) of mGluR5
13) Confidence 0.52 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2994905 Disease Relevance 0.15 Pain Relevance 0
Consistent with the mGluR5 receptor being critical in anxiety-like behavior, there was a significant effect of genotype on center time in the NOF (F(2,28)?
Gene_expression (receptor) of mGluR5 associated with anxiety disorder
14) Confidence 0.52 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2994905 Disease Relevance 0.53 Pain Relevance 0.33
A modified Irwin screen indicated that in most regards, there were no differences between mGluR5 genotypes.
Gene_expression (genotypes) of mGluR5
15) Confidence 0.52 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2994905 Disease Relevance 0.71 Pain Relevance 0.03
Considering that variation in the human mGluR5 gene (GRM5) has been linked to alcohol dependence [37], the present findings may provide additional insight to the relationship between GRM5 variation and its influence on traits such as anxiety and sensation seeking.
Gene_expression (variation) of GRM5 associated with addiction, anxiety disorder and alcohol
16) Confidence 0.52 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2994905 Disease Relevance 0.49 Pain Relevance 0.14
This suggests that, although mGluR5 transmission is critical for the establishment of incentive motivational properties of a cue stimulus (i.e. auditory or visual cue), it does not appear to interfere with the acute conditioned reinforcement or perception of the cue stimuli.
Gene_expression (transmission) of mGluR5
17) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2994905 Disease Relevance 0.15 Pain Relevance 0.24
Here we show that responses to capsaicin or inflammatory pain were significantly reduced in mice lacking glutamate receptor 5 (GluR5) but not GluR6 subunits.
Neg (lacking) Gene_expression (lacking) of glutamate receptor 5 associated with qutenza, glutamate receptor and ipn
18) Confidence 0.34 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 15673679 Disease Relevance 0.76 Pain Relevance 0.55
We also demonstrate significantly higher levels of mGluR5 expression in the right amygdala compared with the left under baseline conditions, suggesting a potential mechanism for right hemispheric lateralization of amygdala function in pain processing.
Gene_expression (expression) of mGluR5 in amygdala associated with pain and amygdala
19) Confidence 0.26 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20554871 Disease Relevance 0.81 Pain Relevance 0.83
For further analysis, the mGluR5 PAM library of active compounds in the original HTS screen as well as the compounds selected for postscreening were clustered using the Mathematica package (72).
Gene_expression (library) of mGluR5 PAM
20) Confidence 0.23 Published 2010 Journal ACS Chemical Neuroscience Section Body Doc Link PMC2857954 Disease Relevance 0 Pain Relevance 0.04

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