INT94652

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Context Info
Confidence 0.48
First Reported 2001
Last Reported 2009
Negated 1
Speculated 1
Reported most in Body
Documents 15
Total Number 21
Disease Relevance 4.18
Pain Relevance 5.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (a) generation of precursor metabolites and energy (a) extracellular region (a)
Anatomy Link Frequency
pigmentation 5
bars 1
liver 1
melanocytes 1
a (Mus musculus)
Pain Link Frequency Relevance Heat
melanocortin 1 receptor 728 100.00 Very High Very High Very High
antagonist 31 99.88 Very High Very High Very High
agonist 40 81.92 Quite High
Kinase C 7 61.52 Quite High
Central nervous system 4 46.96 Quite Low
tolerance 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Freckles 153 99.76 Very High Very High Very High
Targeted Disruption 293 97.12 Very High Very High Very High
Skin Cancer 22 96.08 Very High Very High Very High
Diabetes Mellitus 44 89.40 High High
Obesity 135 88.88 High High
Syndrome 28 88.56 High High
Hyperplasia 20 85.28 High High
Hepatocellular Cancer 4 79.28 Quite High
Hyperphagia 8 79.08 Quite High
Hyperglycemia 16 78.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This domain of ASIP is sufficient for high-affinity receptor binding in vitro.
ASIP Binding (binding) of
1) Confidence 0.48 Published 2009 Journal Pigment Cell & Melanoma Research Section Body Doc Link PMC2784899 Disease Relevance 0 Pain Relevance 0.08
Melanocortin receptors and ATRN are the only molecules known to bind ASIP (Abdel-Malek et al., 2001; He et al., 2003).
ASIP Binding (bind) of
2) Confidence 0.48 Published 2009 Journal Pigment Cell & Melanoma Research Section Body Doc Link PMC2784899 Disease Relevance 0 Pain Relevance 0.12
Because the Mc1r and Agouti proteins interact physically, we tested for epistasis by performing gene interaction analyses (MapManager QTXb [20]).
Agouti Binding (interact) of associated with melanocortin 1 receptor
3) Confidence 0.41 Published 2007 Journal PLoS Biol Section Body Doc Link PMC1945039 Disease Relevance 0 Pain Relevance 0.28
Attractin specifically binds the amino-terminal domain of ASIP, apparently behaving as an accessory receptor for ASIP.
ASIP Binding (receptor) of
4) Confidence 0.37 Published 2009 Journal Pigment Cell & Melanoma Research Section Body Doc Link PMC2784899 Disease Relevance 0 Pain Relevance 0.04
-defensins could bind dog, mouse and human MC1Rs, but not ASIP-YY.
ASIP-YY Neg (not) Binding (bind) of
5) Confidence 0.36 Published 2009 Journal Pigment Cell & Melanoma Research Section Body Doc Link PMC2784899 Disease Relevance 0.15 Pain Relevance 0.49
CBD103 might act by competitively inhibiting ASIP binding, or might elicit cAMP-independent signaling from the MC1R to promote eumelanogenesis (Candille et al., 2007).
ASIP Spec (might) Binding (binding) of associated with melanocortin 1 receptor
6) Confidence 0.36 Published 2009 Journal Pigment Cell & Melanoma Research Section Body Doc Link PMC2784899 Disease Relevance 0.14 Pain Relevance 0.50
Attractin is required for ASIP effects in the mouse, and was suggested to function to enhance ASIP–MC1R binding (Barsh, 2006).
ASIP Binding (binding) of associated with melanocortin 1 receptor
7) Confidence 0.36 Published 2009 Journal Pigment Cell & Melanoma Research Section Body Doc Link PMC2784899 Disease Relevance 0 Pain Relevance 0.19
Neither 1 nM ASIP nor 1 nM ASIP-YY affected this increase, but 10 nM and 100 nM ASIP reduced it by 2/3 and to zero respectively (Figure 5A, striped bars).
ASIP Binding (zero) of in bars
8) Confidence 0.32 Published 2009 Journal Pigment Cell & Melanoma Research Section Body Doc Link PMC2784899 Disease Relevance 0 Pain Relevance 0
Here, we focus on Mc1r and Agouti because their interaction has been well characterized in the lab mouse and thus can be extended to the study of melanism in other taxa.
Agouti Binding (interaction) of associated with melanocortin 1 receptor and freckles
9) Confidence 0.30 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2713407 Disease Relevance 0.23 Pain Relevance 0.79
In this regard, it is interesting to note that the only melanocortin receptor currently known to be expressed in a widespread manner, including in the liver, is Mc5r [61-63], but agouti protein appears to have little to no effect on antagonizing the binding of ?
agouti Binding (binding) of in liver
10) Confidence 0.29 Published 2004 Journal Mol Cancer Section Body Doc Link PMC443512 Disease Relevance 0.72 Pain Relevance 0
In addition to its normal role of regulating pigmentation through Mc1r, agouti can also antagonize ?
agouti Binding (antagonize) of in pigmentation associated with melanocortin 1 receptor
11) Confidence 0.29 Published 2004 Journal Mol Cancer Section Body Doc Link PMC443512 Disease Relevance 1.13 Pain Relevance 0.10
Recombinant murine agouti protein inhibits the binding of [125I]-NDP-?
agouti Binding (binding) of
12) Confidence 0.29 Published 2004 Journal Mol Cancer Section Body Doc Link PMC443512 Disease Relevance 0.94 Pain Relevance 0.15
For each mRNA sample, the level of agouti expression was reported as the ratio of agouti over Gapd mRNA signals.
agouti Binding (ratio) of
13) Confidence 0.29 Published 2004 Journal Mol Cancer Section Body Doc Link PMC443512 Disease Relevance 0.39 Pain Relevance 0
The protein products of three of these genes, Mc1r, Agouti, and Atrn, interact at the surface of pigment-producing cells (melanocytes) and constitute the machinery responsible for “pigment type switching,” the ability of melanocytes to switch between the production of dark brown/black (eumelanin) and light yellow/red pigment (pheomelanin).
Agouti Binding (interact) of in melanocytes associated with melanocortin 1 receptor
14) Confidence 0.29 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2713407 Disease Relevance 0.16 Pain Relevance 0.49
Large deletion in Agouti associated with melanism
Agouti Binding (associated) of associated with freckles
15) Confidence 0.29 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2713407 Disease Relevance 0.32 Pain Relevance 0.09
Two candidate genes, the melanocortin-1 receptor (Mc1r) and its antagonist, the Agouti signaling protein (Agouti), map to independent regions that together are responsible for most of the difference in pigmentation between subspecies.
signaling protein Binding (map) of in pigmentation associated with melanocortin 1 receptor and antagonist
16) Confidence 0.27 Published 2007 Journal PLoS Biol Section Abstract Doc Link PMC1945039 Disease Relevance 0 Pain Relevance 0.40
Two candidate genes, the melanocortin-1 receptor (Mc1r) and its antagonist, the Agouti signaling protein (Agouti), map to independent regions that together are responsible for most of the difference in pigmentation between subspecies.
Agouti Binding (map) of in pigmentation associated with melanocortin 1 receptor and antagonist
17) Confidence 0.27 Published 2007 Journal PLoS Biol Section Abstract Doc Link PMC1945039 Disease Relevance 0 Pain Relevance 0.40
Our results suggest that nearly all of this difference is likely due to the three pigmentation genes Agouti, Mc1r, and Kit, although it is formally possible that other closely linked loci affect the color difference between subspecies.
Agouti Binding (due) of in pigmentation associated with melanocortin 1 receptor
18) Confidence 0.27 Published 2007 Journal PLoS Biol Section Body Doc Link PMC1945039 Disease Relevance 0 Pain Relevance 0.41
Two candidate genes, the melanocortin-1 receptor (Mc1r) and its antagonist, the Agouti signaling protein (Agouti), map to independent regions that together are responsible for most of the difference in pigmentation between subspecies.
Agouti Binding (map) of in pigmentation associated with melanocortin 1 receptor and antagonist
19) Confidence 0.27 Published 2007 Journal PLoS Biol Section Abstract Doc Link PMC1945039 Disease Relevance 0 Pain Relevance 0.40
An analysis of the most extreme phenotypes among our F2 progeny shows a striking association between phenotype and the allelic variation (“light” allele derived from the beach parents [L] and “dark” allele derived from the mainland parents [D]) at Agouti and Mc1r.
Agouti Binding (association) of associated with melanocortin 1 receptor
20) Confidence 0.26 Published 2007 Journal PLoS Biol Section Body Doc Link PMC1945039 Disease Relevance 0 Pain Relevance 0.40

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