INT94658

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.70
First Reported 2001
Last Reported 2010
Negated 0
Speculated 5
Reported most in Abstract
Documents 51
Total Number 56
Disease Relevance 33.65
Pain Relevance 27.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (F2rl1) signal transducer activity (F2rl1)
Anatomy Link Frequency
visceral 4
sensory neurons 4
nociceptors 4
neurons 4
dorsal root ganglion 4
F2rl1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain 118 100.00 Very High Very High Very High
nociceptor 108 100.00 Very High Very High Very High
agonist 92 100.00 Very High Very High Very High
nMDA receptor 196 99.82 Very High Very High Very High
Inflammation 611 99.76 Very High Very High Very High
Neuropeptide 6 99.76 Very High Very High Very High
qutenza 83 99.44 Very High Very High Very High
spastic colon 108 99.36 Very High Very High Very High
dorsal root ganglion 394 99.32 Very High Very High Very High
Root ganglion neuron 12 99.24 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 623 99.76 Very High Very High Very High
Nociception 227 99.68 Very High Very High Very High
Pain 134 99.60 Very High Very High Very High
Hyperplasia 1 99.44 Very High Very High Very High
Neurogenic Inflammation 16 99.38 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

310 99.36 Very High Very High Very High
Ganglion Cysts 431 99.32 Very High Very High Very High
Apoptosis 1 99.26 Very High Very High Very High
Hypersensitivity 134 99.08 Very High Very High Very High
Hyperalgesia 37 98.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Stimulation of PAR-2 excites and sensitizes rat cutaneous C-nociceptors to heat.
Positive_regulation (Stimulation) of PAR-2 in nociceptors associated with c fibre and nociceptor
1) Confidence 0.70 Published 2004 Journal Neuroreport Section Title Doc Link 15486484 Disease Relevance 0.19 Pain Relevance 1.22
These data provide novel evidence that activation of peripheral PAR-2 is pro-nociceptive, producing thermal hyperalgesia and also triggering pain sensation, by itself, independently of mast cell degranulation.
Positive_regulation (activation) of PAR-2 in mast cell associated with nociception, pain and thermal hyperalgesia
2) Confidence 0.70 Published 2001 Journal Neuroreport Section Abstract Doc Link 11277570 Disease Relevance 0.76 Pain Relevance 0.43
The Fos expression caused by PAR-2 activation was inhibited by ablation of capsaicin-sensitive sensory neurons.
Positive_regulation (activation) of PAR-2 in sensory neurons associated with qutenza
3) Confidence 0.69 Published 2004 Journal Neuroreport Section Abstract Doc Link 15232294 Disease Relevance 0.41 Pain Relevance 0.43
Our data thus reveal that activation of PAR-2 in the parotid gland can cause activation of trigeminal nociceptive neurons via capsaicin-sensitive sensory nerves most probably by a non-inflammatory mechanism.
Positive_regulation (activation) of PAR-2 in neurons associated with nociception, inflammation and qutenza
4) Confidence 0.69 Published 2004 Journal Neuroreport Section Abstract Doc Link 15232294 Disease Relevance 0.50 Pain Relevance 0.44
To clarify involvement of protease-activated receptor-2 (PAR-2) in parotid pain, we examined whether PAR-2 activation in the parotid gland could activate trigeminal nociceptive neurons in anesthetized rats, by analyzing immunoreactive Fos as a nociceptive marker.
Positive_regulation (activation) of PAR-2 in parotid gland associated with nociception and pain
5) Confidence 0.69 Published 2004 Journal Neuroreport Section Abstract Doc Link 15232294 Disease Relevance 0.37 Pain Relevance 0.29
Activation of trigeminal nociceptive neurons by parotid PAR-2 activation in rats.
Positive_regulation (activation) of PAR-2 in neurons associated with nociception and qutenza
6) Confidence 0.69 Published 2004 Journal Neuroreport Section Title Doc Link 15232294 Disease Relevance 0.45 Pain Relevance 0.60
We found that activation of PAR-2 in these cells strongly inhibited M-type potassium currents (conducted by Kv7 potassium channels).
Positive_regulation (activation) of PAR-2 associated with potassium channel
7) Confidence 0.69 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 18971466 Disease Relevance 1.08 Pain Relevance 0.47
In this study we investigated the nociceptive pathways induced by activation of protease-activated receptor 2 (PAR-2) in damage-sensing (nociceptive) neurons from rat dorsal root ganglion (DRG).
Spec (investigated) Positive_regulation (activation) of protease-activated receptor 2 in dorsal root ganglion associated with ganglion cysts, nociception and dorsal root ganglion
8) Confidence 0.69 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 18971466 Disease Relevance 1.01 Pain Relevance 0.46
In this study we investigated the nociceptive pathways induced by activation of protease-activated receptor 2 (PAR-2) in damage-sensing (nociceptive) neurons from rat dorsal root ganglion (DRG).
Spec (investigated) Positive_regulation (activation) of PAR-2 in dorsal root ganglion associated with ganglion cysts, nociception and dorsal root ganglion
9) Confidence 0.69 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 18971466 Disease Relevance 1.07 Pain Relevance 0.47
Activation of protease-activated receptor-2 (PAR-2), a receptor activated by trypsin/tryptase, induces neurally mediated gastric mucus secretion accompanied by mucosal cytoprotection.
Positive_regulation (Activation) of PAR-2
10) Confidence 0.69 Published 2002 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12106807 Disease Relevance 0 Pain Relevance 0
Activation of protease-activated receptor-2 (PAR-2), a receptor activated by trypsin/tryptase, induces neurally mediated gastric mucus secretion accompanied by mucosal cytoprotection.
Positive_regulation (Activation) of protease-activated receptor-2
11) Confidence 0.69 Published 2002 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12106807 Disease Relevance 0 Pain Relevance 0
Our results provide novel evidence that in addition to stimulating neurally mediated mucus secretion, activation of PAR-2 suppresses gastric acid secretion independently of prostanoid production or sensory neurons.
Positive_regulation (activation) of PAR-2 in sensory neurons
12) Confidence 0.69 Published 2002 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12106807 Disease Relevance 0 Pain Relevance 0.10
Moreover, protein kinase A does not participate in the inhibition of P2X3 currents caused by PAR2 activation.
Positive_regulation (activation) of PAR2
13) Confidence 0.69 Published 2010 Journal Neuroreport Section Abstract Doc Link 20118742 Disease Relevance 0.46 Pain Relevance 0.39
These results suggest that the enhanced pain response caused by PAR2 activation is not through direct increase of the P2X3 current amplitude, and the acceleration of P2X3 opening may participate in the enhanced pain response in a long-time view.
Positive_regulation (activation) of PAR2 associated with pain
14) Confidence 0.69 Published 2010 Journal Neuroreport Section Abstract Doc Link 20118742 Disease Relevance 0.50 Pain Relevance 0.43
Activation of PAR2 modulates diverse gastrointestinal functions, such as motility, ionic exchange, paracellular permeability, sensory functions and inflammation (27).
Positive_regulation (Activation) of PAR2 associated with inflammation
15) Confidence 0.68 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2923781 Disease Relevance 0.99 Pain Relevance 0.65
The present findings demonstrate that activation of the PAR-2 localized on capsaicin-sensitive trigeminal nociceptive afferent nerves induces vasodilatation in the dural vascular bed by mechanisms involving NO and CGRP release.
Positive_regulation (activation) of PAR-2 in nerves associated with nociception, qutenza, increased venous pressure under development and calcitonin gene-related peptide
16) Confidence 0.68 Published 2009 Journal Neuroscience Section Abstract Doc Link 19362118 Disease Relevance 0.34 Pain Relevance 1.02
The present work explored the functional significance of the capsaicin-sensitive subpopulation of dural afferent nerves via their contribution to the meningeal vascular responses evoked through activation of the proteinase-activated receptor 2 (PAR-2).
Positive_regulation (activation) of PAR-2 in nerves associated with qutenza
17) Confidence 0.68 Published 2009 Journal Neuroscience Section Abstract Doc Link 19362118 Disease Relevance 0.39 Pain Relevance 0.57
The present work explored the functional significance of the capsaicin-sensitive subpopulation of dural afferent nerves via their contribution to the meningeal vascular responses evoked through activation of the proteinase-activated receptor 2 (PAR-2).
Positive_regulation (activation) of proteinase-activated receptor 2 in nerves associated with qutenza
18) Confidence 0.68 Published 2009 Journal Neuroscience Section Abstract Doc Link 19362118 Disease Relevance 0.39 Pain Relevance 0.57
Thus, specific expression of spinal Fos following peripheral PAR-2 activation is detectable in mast cell-depleted rats, suggesting activation of spinal nociceptive neurons, which is partially mediated by activation of PKC.
Positive_regulation (activation) of PAR-2 in mast cell associated with nociception and kinase c
19) Confidence 0.65 Published 2002 Journal Neuroreport Section Abstract Doc Link 11930172 Disease Relevance 0.25 Pain Relevance 0.33
The role of protease activated receptor-2 (PAR-2) activation in trigeminal nociception and in induction of functional competence in the delta opioid receptor (DOR) is not known.
Positive_regulation (activation) of protease activated receptor-2 associated with nociception and opioid receptor
20) Confidence 0.61 Published 2006 Journal Pain Section Abstract Doc Link 16781076 Disease Relevance 0.31 Pain Relevance 0.72

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox