INT94688

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Context Info
Confidence 0.21
First Reported 2001
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 4
Total Number 7
Disease Relevance 2.35
Pain Relevance 2.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein targeting (Gphn) plasma membrane (Gphn) cytoskeleton (Gphn)
intracellular (Gphn) protein binding, bridging (Gphn) cytoplasm (Gphn)
Anatomy Link Frequency
spinal cord 2
Gphn (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 11 99.82 Very High Very High Very High
Kinase C 11 99.78 Very High Very High Very High
Opioid 1 99.24 Very High Very High Very High
Analgesic 1 98.88 Very High Very High Very High
allodynia 31 97.32 Very High Very High Very High
narcan 7 96.96 Very High Very High Very High
diabetic neuropathy 1 94.72 High High
Dorsal horn 55 92.92 High High
Pain 24 88.52 High High
Pyramidal cell 72 87.68 High High
Disease Link Frequency Relevance Heat
Epilepsy 48 98.72 Very High Very High Very High
Neuropathic Pain 51 97.32 Very High Very High Very High
Nociception 38 94.80 High High
Diabetic Neuropathy 1 94.72 High High
Diabetes Mellitus 2 93.12 High High
Pain 25 88.52 High High
Status Epilepticus 171 85.08 High High
Convulsion 54 85.08 High High
Targeted Disruption 7 82.40 Quite High
INFLAMMATION 37 80.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We also detected a down-regulation of the gephyrin gene and an up-regulation of the GABARAP gene in accordance with the results obtained from the hippocampi of humans with TLE [86].
Negative_regulation (down-regulation) of gephyrin associated with epilepsy
1) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2873964 Disease Relevance 0.34 Pain Relevance 0.10
2 subunit-containing GABAA receptors [87], [88], and the gephyrin down-regulation could further corroborate the hypothesis that the ?
Negative_regulation (down-regulation) of gephyrin
2) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2873964 Disease Relevance 0.37 Pain Relevance 0.19
We also detected a down-regulation of the gephyrin (?
Negative_regulation (down-regulation) of gephyrin
3) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2873964 Disease Relevance 0.30 Pain Relevance 0.11
In this study, pharmacological effects of a novel PKC-beta isoform selective inhibitor, JTT-010 ((2R)-3-(2-aminomethyl-2,3-dihydro-1H-3a-azacyclopenta(a)inden-8-yl)-4-phenylaminopyrrole-2,5-dione monomethanesulphonate), on diabetic neuropathy were examined.
Spec (examined) Negative_regulation (inhibitor) of isoform associated with kinase c and diabetic neuropathy
4) Confidence 0.06 Published 2005 Journal Diabetes Obes Metab Section Abstract Doc Link 16050952 Disease Relevance 0.34 Pain Relevance 0.35
To test this hypothesis, we used a recently developed, selective inhibitor of the gamma isoform of PKC (KIG31-1) [44]–[47].
Negative_regulation (inhibitor) of isoform
5) Confidence 0.01 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2043493 Disease Relevance 0.61 Pain Relevance 0.40
Enhanced mu-opioid responses in the spinal cord of mice lacking protein kinase Cgamma isoform.
Negative_regulation (lacking) of isoform in spinal cord associated with analgesic, opioid and spinal cord
6) Confidence 0.00 Published 2001 Journal J. Biol. Chem. Section Title Doc Link 11278552 Disease Relevance 0.31 Pain Relevance 1.10
Repeated s.c. administration of naloxone for 7 days resulted in a significant enhancement of the increased [(35)S]GTPgammaS binding by DAMGO to membranes of the spinal cord obtained from mice lacking the protein kinase Cgamma isoform.
Negative_regulation (lacking) of isoform in spinal cord associated with narcan and spinal cord
7) Confidence 0.00 Published 2003 Journal Neurosci. Lett. Section Abstract Doc Link 12566163 Disease Relevance 0.07 Pain Relevance 0.71

General Comments

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