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Context Info
Confidence 0.17
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.39
Pain Relevance 1.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Sp1) nucleus (Sp1) intracellular (Sp1)
DNA binding (Sp1) transcription factor binding (Sp1) cytoplasm (Sp1)
Sp1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
mu opioid receptor 8 99.24 Very High Very High Very High
cINOD 10 97.52 Very High Very High Very High
metalloproteinase 2 80.96 Quite High
opioid receptor 1 75.00 Quite High
tetrodotoxin 1 74.64 Quite High
Morphine 1 64.48 Quite High
Disease Link Frequency Relevance Heat
Lung Cancer 1 83.88 Quite High
Repression 1 82.40 Quite High
INFLAMMATION 2 79.04 Quite High
Embryonal Carcinoma 1 70.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Sp1 overexpression studies also led to increases in cytochrome c transactivation and mRNA levels.
Positive_regulation (overexpression) of Gene_expression (overexpression) of Sp1
1) Confidence 0.17 Published 2001 Journal J. Biol. Chem. Section Abstract Doc Link 11279044 Disease Relevance 0 Pain Relevance 0.07
Electrophoretic mobility shift assays show that Sp1 and Sp3 proteins constitutively bind to this consensus sequence and overexpression of Sp1 may enhance MMP-2 expression.
Positive_regulation (overexpression) of Gene_expression (overexpression) of Sp1
2) Confidence 0.14 Published 2002 Journal J. Biol. Chem. Section Abstract Doc Link 12087091 Disease Relevance 0.32 Pain Relevance 0.85
Overexpression of Sp1 strongly enhanced MOR promoter activity, and the histone deacetylase inhibitor trichostatin A also increased promoter activity.
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of Sp1 associated with mu opioid receptor
3) Confidence 0.13 Published 2010 Journal Mol. Pharmacol. Section Abstract Doc Link 20385708 Disease Relevance 0.07 Pain Relevance 0.36

General Comments

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