INT947

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Context Info
Confidence 0.59
First Reported 1979
Last Reported 2010
Negated 5
Speculated 0
Reported most in Abstract
Documents 20
Total Number 20
Disease Relevance 4.09
Pain Relevance 5.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
bowel 4
plasma 2
intestinal cells 1
olfactory nerve 1
small intestine 1
Mln (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 11 100.00 Very High Very High Very High
abdominal pain 9 100.00 Very High Very High Very High
antagonist 7 100.00 Very High Very High Very High
narcan 7 100.00 Very High Very High Very High
agonist 5 100.00 Very High Very High Very High
Cholecystokinin 13 99.92 Very High Very High Very High
Neuropeptide 8 99.92 Very High Very High Very High
Somatostatin 9 99.76 Very High Very High Very High
substance P 2 99.28 Very High Very High Very High
Opioid 2 99.28 Very High Very High Very High
Disease Link Frequency Relevance Heat
Abdominal Pain 9 100.00 Very High Very High Very High
Syndrome 1 99.98 Very High Very High Very High
Intestinal Obstruction 6 99.44 Very High Very High Very High
Functional Bowel Disorder 7 98.92 Very High Very High Very High
Stress 1 98.76 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

17 98.56 Very High Very High Very High
Diarrhoea 3 96.24 Very High Very High Very High
Systemic Sclerosis 102 91.16 High High
Dislocations 1 79.20 Quite High
Vomiting 4 79.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Endogenous motilin levels were not affected by meal ingestion.
Neg (not) Regulation (affected) of motilin
1) Confidence 0.59 Published 2002 Journal Dig. Dis. Sci. Section Abstract Doc Link 12184523 Disease Relevance 0.15 Pain Relevance 0.08
Motilin in children with recurrent abdominal pain: a controlled study.
Regulation (controlled) of Motilin associated with abdominal pain
2) Confidence 0.45 Published 1994 Journal Acta Paediatr. Section Title Doc Link 8086735 Disease Relevance 0.61 Pain Relevance 0.67
The action of motilin was unaffected by extrinsic denervation (cervical vagotomy or splanchnicectomy), hexamethonium, and propranolol.
Neg (unaffected) Regulation (unaffected) of motilin
3) Confidence 0.45 Published 1988 Journal Gastroenterology Section Abstract Doc Link 3410223 Disease Relevance 0 Pain Relevance 0.18
Effects and mechanisms of action of motilin on the cat sphincter of Oddi.
Regulation (Effects) of motilin associated with narcan
4) Confidence 0.45 Published 1988 Journal Gastroenterology Section Title Doc Link 3410223 Disease Relevance 0 Pain Relevance 0.20
Perfusion of the segments with naloxone (up to 3.0 micrograms/ml) did not affect the responses of the bowel to motilin, suggesting that opioid systems are not directly involved in the contractile responses.
Neg (not) Regulation (affect) of motilin in bowel associated with narcan and opioid
5) Confidence 0.44 Published 1986 Journal Eur. J. Pharmacol. Section Abstract Doc Link 3792443 Disease Relevance 0 Pain Relevance 0.23
Cholinergic regulation of motilin release from isolated canine intestinal cells.
Regulation (regulation) of motilin in intestinal cells
6) Confidence 0.38 Published 1993 Journal Peptides Section Title Doc Link 8483799 Disease Relevance 0 Pain Relevance 0.18
The actions of motilin, luteinizing hormone releasing hormone, cholecystokinin, somatostatin, vasoactive intestinal peptide, and other peptides on rat cerebral cortical neurons.
Regulation (actions) of motilin in neurons associated with somatostatin, enkephalin and cholecystokinin
7) Confidence 0.34 Published 1980 Journal Can. J. Physiol. Pharmacol. Section Title Doc Link 6107174 Disease Relevance 0 Pain Relevance 0.58
Altered motilin levels have been found in irritable bowel syndrome (IBS) patients, but in these studies motilin levels were analysed without the knowledge of the phases of MMC.
Regulation (Altered) of motilin in bowel associated with spastic colon
8) Confidence 0.26 Published 2005 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 15670264 Disease Relevance 0.33 Pain Relevance 0.51
We designed a model of intestinal obstruction (IO) to study the histological alterations in the intestinal wall and the mesenteric lymph nodes (MLN).
Regulation (alterations) of MLN in MLN associated with intestinal obstruction
9) Confidence 0.24 Published 1989 Journal G E N Section Abstract Doc Link 2535559 Disease Relevance 0.63 Pain Relevance 0.13
The motilin receptor antagonists GM 109 and [phe3, leu13]-motilin, both shifted the concentration-response curves for each agonist to the right, but did not affect concentration-response relationships for the muscarinic agonist carbachol.
Neg (not) Regulation (affect) of motilin associated with antagonist and agonist
10) Confidence 0.12 Published 1999 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 10081621 Disease Relevance 0 Pain Relevance 0.41
Changes in plasma levels of motilin and PYY may contribute to the clinical expression of IBS, such as the presence of visceral hypersensitivity or a predominant bowel habit.


Regulation (Changes) of motilin in bowel
11) Confidence 0.10 Published 2006 Journal Scand. J. Gastroenterol. Section Body Doc Link 16484122 Disease Relevance 0 Pain Relevance 0
Since it is known that gastric acidification modulates the action of motilin [26], we examined the relationship between the effects of ghrelin on gastroduodenal motility and intragastric pH.
Regulation (modulates) of motilin
12) Confidence 0.07 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2915652 Disease Relevance 0 Pain Relevance 0
Effect of methionine-enkephalin analog (FK 33-824) on plasma motilin.
Regulation (Effect) of motilin in plasma associated with enkephalin
13) Confidence 0.06 Published 1986 Journal Gastroenterol. Jpn. Section Title Doc Link 3770354 Disease Relevance 0 Pain Relevance 0.45
The effect of motilin is a direct one, whereas the effect of somatostatin is probably due to inhibition of regulatory peptides which in turn inhibit the emptying in the sense of a feedback.
Regulation (effect) of motilin associated with somatostatin
14) Confidence 0.06 Published 1988 Journal Z Gastroenterol Verh Section Abstract Doc Link 2454545 Disease Relevance 0 Pain Relevance 0.27
The effects of motilin, neurotensin, and thyrotropin-releasing hormone were greatly reduced or abolished by perfusion of the preparation with tetrodotoxin.
Regulation (effects) of motilin associated with tetrodotoxin
15) Confidence 0.06 Published 1979 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 115560 Disease Relevance 0 Pain Relevance 0.52
When the IBS patients were divided into subgroups based on the predominant syndrome changes in the plasma levels of gastrin, motilin and pancreatic polypeptide (PP) were seen.
Regulation (changes) of motilin in plasma associated with syndrome and spastic colon
16) Confidence 0.05 Published 1987 Journal Scand. J. Gastroenterol. Suppl. Section Abstract Doc Link 3477012 Disease Relevance 0.35 Pain Relevance 0.75
In addition, the olfactory nerve fibres were not immunoreactive for methionine- and leucine-enkephalins, motilin, neuropeptide Y, substance P, cholecystokinin-8 and tyrosine-hydroxylase.
Neg (not) Regulation (immunoreactive) of motilin in olfactory nerve associated with neuropeptide, enkephalin, cholecystokinin and substance p
17) Confidence 0.05 Published 1989 Journal Brain Res. Section Abstract Doc Link 2765872 Disease Relevance 0 Pain Relevance 0.25
Cells immunoreactive for motilin, CCK, GIP, and secretin were observed in the proximal small intestine and those immunoreactive for neurotensin were found only in the ileum.
Regulation (immunoreactive) of motilin in small intestine associated with cholecystokinin
18) Confidence 0.03 Published 2000 Journal Anat Histol Embryol Section Abstract Doc Link 10916880 Disease Relevance 0 Pain Relevance 0.41
Thus, small bowel-related and gastric motility-independent factors including increased stiffness of small bowel wall with altered muscle function [12,16,60], altered motilin levels [61] and/or an "acidic stress" with sensorimotor disorders [62,63] are likely involved in this dysfunction.
Regulation (altered) of motilin in bowel associated with stress
19) Confidence 0.02 Published 2008 Journal BMC Gastroenterol Section Body Doc Link PMC2276219 Disease Relevance 0.83 Pain Relevance 0.03
This notion is supported further by the finding that activation markers were up regulated on CD11c+ T cells both in the lung and in the draining MLN.
Regulation (regulated) of MLN in lung
20) Confidence 0.01 Published 2005 Journal Respir Res Section Body Doc Link PMC1184101 Disease Relevance 0.34 Pain Relevance 0.03

General Comments

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