INT9473

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Context Info
Confidence 0.48
First Reported 1992
Last Reported 2010
Negated 7
Speculated 2
Reported most in Body
Documents 66
Total Number 72
Disease Relevance 46.77
Pain Relevance 2.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (MUC1) plasma membrane (MUC1) nucleus (MUC1)
cytoplasm (MUC1)
Anatomy Link Frequency
epithelial cells 6
gastric juice 3
extracellular matrix 2
gum 1
brainstem 1
MUC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
corticosteroid 7 98.92 Very High Very High Very High
endometriosis 6 98.82 Very High Very High Very High
medulla 1 98.00 Very High Very High Very High
Inflammation 157 96.60 Very High Very High Very High
Chronic pancreatitis 38 95.92 Very High Very High Very High
Inflammatory response 87 93.08 High High
Thoracotomy 2 92.92 High High
Pain 10 89.96 High High
peptic ulcer disease 172 88.76 High High
palliative 1 87.80 High High
Disease Link Frequency Relevance Heat
Immunization 17 100.00 Very High Very High Very High
Nervous System Paraneoplastic Syndromes 16 100.00 Very High Very High Very High
Nutritional Deficiencies 12 100.00 Very High Very High Very High
Syndrome 387 99.98 Very High Very High Very High
Cancer 581 99.92 Very High Very High Very High
Sprains And Strains 1122 99.90 Very High Very High Very High
Malignant Neoplastic Disease 32 99.84 Very High Very High Very High
Bronchitis 7 99.82 Very High Very High Very High
Ataxia 1 99.80 Very High Very High Very High
Disease 519 99.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This inability to detect membrane bound MUC1 because of glycosylation differences is documented in the literature where the presence of MUC1 on hematopoietic cells in patients having certain cancers was ignored for some time [27].
MUC1 Binding (bound) of in hematopoietic cells associated with cancer
1) Confidence 0.48 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2927371 Disease Relevance 0.65 Pain Relevance 0
If all transmembrane mucins are involved in resisting rose bengal penetration, then these data conflict in principle with our findings of increased levels of membrane bound MUC1 in SS versus NDE and no difference in membrane bound MUC16 in our previous work with SS, KCS and NDE [30], since rose bengal staining is found clinically in greater amounts in Sjogren’s syndrome patients [48].
MUC1 Binding (bound) of associated with sjoegrens syndrome, syndrome and dry eye
2) Confidence 0.48 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2927371 Disease Relevance 0.84 Pain Relevance 0
When the pathogen does bind to MUC1, the extracellular domain of the mucin is released from the epithelial surface, thereby acting as a releasable decoy and preventing prolonged adherence.
mucin Binding (bind) of
3) Confidence 0.47 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2752161 Disease Relevance 0.45 Pain Relevance 0.03
We now demonstrate that the majority of H. pylori strains can bind to human MUC1 and that release of MUC1 following binding limits adhesion to the cell surface.
MUC1 Binding (bind) of associated with sprains and strains and adhesions
4) Confidence 0.47 Published 2009 Journal PLoS Pathogens Section Abstract Doc Link PMC2752161 Disease Relevance 1.20 Pain Relevance 0.08
When the pathogen does not bind to MUC1, the mucin sterically inhibits adhesion to other potential cell surface ligands.
MUC1 Neg (not) Binding (bind) of associated with adhesions
5) Confidence 0.47 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2752161 Disease Relevance 0.42 Pain Relevance 0.03
In this study we have shown that, in vitro, H. pylori carrying these adhesins caused the gastric epithelial cells to shed MUC1 which bound to the bacteria.
MUC1 Binding (bound) of in epithelial cells
6) Confidence 0.47 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2752161 Disease Relevance 0.35 Pain Relevance 0
MUC1 interacts directly with the I?
MUC1 Binding (interacts) of
7) Confidence 0.47 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2752161 Disease Relevance 1.13 Pain Relevance 0.04
This demonstrates that binding to MUC1 occurred via MUC1 oligosaccharides bound by both the BabA and SabA adhesins.
MUC1 Binding (binding) of
8) Confidence 0.47 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2752161 Disease Relevance 0.45 Pain Relevance 0
The demonstration that H. pylori binds to MUC1 and that MUC1 can be shed from the epithelial surface indicated that MUC1 could act as a releasable decoy upon bacterial adherence.
MUC1 Binding (binds) of
9) Confidence 0.47 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2752161 Disease Relevance 0.44 Pain Relevance 0
Assessment of MUC1 binding to H. pylori by confocal microscopy
MUC1 Binding (binding) of
10) Confidence 0.47 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2752161 Disease Relevance 0.10 Pain Relevance 0
H. pylori bind to MUC1 isolated from epithelial cells as well as to MUC1 shed into the gastric juice of human patients.
MUC1 Binding (bind) of in gastric juice
11) Confidence 0.47 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2752161 Disease Relevance 0.47 Pain Relevance 0
H. pylori binds to MUC1 carbohydrate structures and binding is dependent on H. pylori adhesins
MUC1 Binding (binds) of
12) Confidence 0.47 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2752161 Disease Relevance 0.24 Pain Relevance 0
A single J99 SabA deletion mutant resulted in a small non-significant decrease in MUC1 binding and a single J99 BabA deletion mutant showed intermediate MUC1 binding (Figure 2B).
MUC1 Binding (binding) of
13) Confidence 0.47 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2752161 Disease Relevance 0.44 Pain Relevance 0
A single J99 SabA deletion mutant resulted in a small non-significant decrease in MUC1 binding and a single J99 BabA deletion mutant showed intermediate MUC1 binding (Figure 2B).
MUC1 Binding (binding) of
14) Confidence 0.47 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2752161 Disease Relevance 0.34 Pain Relevance 0
Binding of H. pylori to MUC1 was determined by sandwich ELISA using biotinylated bacteria.
MUC1 Binding (Binding) of
15) Confidence 0.47 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2752161 Disease Relevance 0 Pain Relevance 0
Infection results in progressive depletion of cellular MUC1 and binding of MUC1 to H. pylori
MUC1 Binding (binding) of associated with infection
16) Confidence 0.47 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2752161 Disease Relevance 0.10 Pain Relevance 0
In contrast, binding to MUC1, as we have shown previously for other mucins [10],[11], is dependent on the presence of H. pylori adhesins.
MUC1 Binding (binding) of
17) Confidence 0.47 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2752161 Disease Relevance 0.53 Pain Relevance 0
These observations stand in contrast to our results that demonstrated no difference in membrane bound MUC1 in the conjunctiva of SS subjects compared to aqueous deficient dry eye and increased expression compared to normal subjects [30].
MUC1 Binding (bound) of in conjunctiva associated with syndrome and dry eye
18) Confidence 0.37 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2927371 Disease Relevance 0.92 Pain Relevance 0
Recent work by Argueso et al. [49], however, suggests that, in vitro, it is the interaction of the carbohydrate binding protein galectin-3 with the carbohydrate portion of both MUC1 and MUC16 that creates a protective barrier to the penetration of dye such as rose bengal.
MUC1 Binding (interaction) of
19) Confidence 0.37 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2927371 Disease Relevance 0.73 Pain Relevance 0
Our data are consistent with the interpretation that shorter forms of MUC1 are less efficient at sterically inhibiting attachment or acting as releasable decoys, thereby allowing increased bacterial binding to the epithelial surface and exacerbation of pathology.
MUC1 Binding (binding) of
20) Confidence 0.36 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2752161 Disease Relevance 0.63 Pain Relevance 0.10

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