INT94744

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Context Info
Confidence 0.44
First Reported 2001
Last Reported 2002
Negated 1
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 2.83
Pain Relevance 1.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il1b) aging (Il1b) extracellular region (Il1b)
Anatomy Link Frequency
spleen 2
Il1b (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 3 100.00 Very High Very High Very High
cytokine 12 99.34 Very High Very High Very High
Inflammation 3 99.28 Very High Very High Very High
fluoxetine 4 98.36 Very High Very High Very High
antidepressant 5 97.12 Very High Very High Very High
shoulder pain 5 95.28 Very High Very High Very High
Neuropathic pain 1 93.80 High High
visual analogue scale 1 45.68 Quite Low
Pain 5 43.52 Quite Low
Inflammatory response 1 36.84 Quite Low
Disease Link Frequency Relevance Heat
Synovitis 4 100.00 Very High Very High Very High
Wallerian Degeneration 15 99.44 Very High Very High Very High
INFLAMMATION 4 99.28 Very High Very High Very High
Disease 5 96.28 Very High Very High Very High
Shoulder Pain 5 95.28 Very High Very High Very High
Neuropathic Pain 1 93.80 High High
Acute-phase Reaction 1 91.60 High High
Fever 1 87.32 High High
Hypothermia 1 86.32 High High
Necrosis 1 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast to rapid-WD, the production of TNFalpha, IL-1alpha, and IL-1beta protein was deficient in slow-WD, although their mRNAs were expressed. mRNA expression and protein production of TNFalpha, IL-1alpha, and IL-1beta were differentially regulated during rapid-WD and slow-WD, suggesting that mRNA expression, by itself, is no indication of the functional involvement of cytokines in WD.
Regulation (regulated) of Transcription (expression) of IL-1beta associated with wallerian degeneration and cytokine
1) Confidence 0.44 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 11943808 Disease Relevance 1.32 Pain Relevance 0.26
The effects of antidepressants on the responsiveness to LPS are probably not mediated by their effects on peripheral proinflammatory cytokine production, because LPS-induced expression of TNFalpha and IL-1beta mRNA in the spleen (assessed by semiquantitative in situ hybridization) was not altered following chronic treatment with either fluoxetine or imipramine.
Neg (not) Regulation (altered) of Transcription (expression) of IL-1beta in spleen associated with antidepressant, fluoxetine and cytokine
2) Confidence 0.26 Published 2001 Journal Neuropsychopharmacology Section Abstract Doc Link 11282253 Disease Relevance 0.48 Pain Relevance 0.56
The mRNA expression levels of interleukin-1beta (IL-1beta) and interleukin-1 receptor antagonists produced in the synovitis reflect the magnitude of inflammation.
Regulation (reflect) of Transcription (expression) of interleukin-1beta associated with inflammation, antagonist and synovitis
3) Confidence 0.00 Published 2002 Journal J. Orthop. Res. Section Abstract Doc Link 12472254 Disease Relevance 1.02 Pain Relevance 0.43

General Comments

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