INT94745

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Context Info
Confidence 0.15
First Reported 2001
Last Reported 2001
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.48
Pain Relevance 0.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il1b) signal transduction (Tlr4) aging (Il1b)
extracellular region (Il1b) plasma membrane (Tlr4) intracellular (Tlr4)
Anatomy Link Frequency
spleen 2
Tlr4 (Mus musculus)
Il1b (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 2 99.58 Very High Very High Very High
antidepressant 5 97.36 Very High Very High Very High
fluoxetine 4 94.84 High High
Disease Link Frequency Relevance Heat
Fever 1 87.80 High High
Hypothermia 1 86.80 High High
Acute-phase Reaction 1 84.56 Quite High
Weight Loss 1 73.84 Quite High
Body Weight 1 73.64 Quite High
Appetite Loss 1 73.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effects of antidepressants on the responsiveness to LPS are probably not mediated by their effects on peripheral proinflammatory cytokine production, because LPS-induced expression of TNFalpha and IL-1beta mRNA in the spleen (assessed by semiquantitative in situ hybridization) was not altered following chronic treatment with either fluoxetine or imipramine.
LPS Positive_regulation (induced) of Transcription (expression) of IL-1beta in spleen associated with antidepressant, fluoxetine and cytokine
1) Confidence 0.15 Published 2001 Journal Neuropsychopharmacology Section Abstract Doc Link 11282253 Disease Relevance 0.48 Pain Relevance 0.56

General Comments

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