INT94756

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Context Info
Confidence 0.49
First Reported 2000
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 4.59
Pain Relevance 0.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (PSEN2) endoplasmic reticulum (PSEN2) embryo development (PSEN2)
protein complex (PSEN2) cytosol (PSEN2) peptidase activity (PSEN2)
Anatomy Link Frequency
MCF7 1
apoptotic cells 1
fibroblasts 1
PSEN2 (Homo sapiens)
PSEN2 - N141I (1)
Pain Link Frequency Relevance Heat
addiction 5 100.00 Very High Very High Very High
bradykinin 75 99.98 Very High Very High Very High
Abeta 6 99.44 Very High Very High Very High
antagonist 5 95.68 Very High Very High Very High
Dismenorea 1 75.00 Quite High
Inflammation 40 50.00 Quite Low
Enkephalin 2 25.00 Low Low
agonist 9 5.00 Very Low Very Low Very Low
Rsd 6 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 77 99.68 Very High Very High Very High
Disease 212 99.64 Very High Very High Very High
Down Syndrome 16 99.28 Very High Very High Very High
Inflammatory Breast Neoplasms 114 95.84 Very High Very High Very High
Cancer 141 92.64 High High
Breast Cancer 60 92.04 High High
Necrosis 2 89.56 High High
Sprains And Strains 13 88.88 High High
Head & Neck Cancer 1 87.52 High High
Death 10 84.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The number of apoptotic cells in WB-2054-M5 cells after transfection of wild-type p53 increased and the apoptotic index markedly increased in the Ad5CMV-p53 group.
Positive_regulation (increased) of Ad5 in apoptotic cells associated with apoptosis
1) Confidence 0.49 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2816308 Disease Relevance 1.48 Pain Relevance 0
C100/TGN co-transfected with mt PS2 increased levels or ratios of intracellular as well as secreted Abeta42 at similar levels to those with C100 without signals (C100/WT), whereas C100/ER yielded a negligible level of Abeta, which was not affected by co-transfection of mt PS2.
Positive_regulation (co-transfection) of PS2 associated with abeta
2) Confidence 0.31 Published 2001 Journal J. Biol. Chem. Section Abstract Doc Link 11283011 Disease Relevance 0.30 Pain Relevance 0.12
C100/TGN co-transfected with mt PS2 increased levels or ratios of intracellular as well as secreted Abeta42 at similar levels to those with C100 without signals (C100/WT), whereas C100/ER yielded a negligible level of Abeta, which was not affected by co-transfection of mt PS2.
Positive_regulation (increased) of PS2 associated with abeta
3) Confidence 0.27 Published 2001 Journal J. Biol. Chem. Section Abstract Doc Link 11283011 Disease Relevance 0.32 Pain Relevance 0.11
As expected, estrogen stimulation (Figure 5c, lane 2 versus lane 1) greatly increased the pS2 mRNA, and Faslodex™ (Figure 5c, lane 9 versus lane 2) blocked this estrogen-stimulated change.
Positive_regulation (increased) of pS2
4) Confidence 0.23 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2246173 Disease Relevance 0 Pain Relevance 0
Expression of the ER and PgR genes, c-myb, c-erb2, c-myc, c-fos, the epidermal growth factor receptor (EGFR) gene, and pS2 (a small secreted protein isolated from MCF7 cells after induction by 17?
Positive_regulation (induction) of pS2 in MCF7
5) Confidence 0.21 Published 2000 Journal Breast Cancer Res Section Body Doc Link PMC138665 Disease Relevance 1.72 Pain Relevance 0
Compound E had neither an effect on BK-induced ERK activation in Trisomy 21 and control fibroblasts, nor on BK-stimulated ERK in PS-2 (N141I) AD fibroblasts.
Neg (nor) Positive_regulation (stimulated) of PS-2 (N141I) in fibroblasts associated with down syndrome, disease and bradykinin
6) Confidence 0.21 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2644820 Disease Relevance 0.54 Pain Relevance 0.33
The estrogen receptor ER(alpha) and the estrogen receptor-regulated progesterone receptor and pS2 mRNA levels were increased by treatment with rotundifuran and agnuside within 24 h, and the effects could be reversed by ICI 182,780.
Positive_regulation (increased) of pS2 mRNA
7) Confidence 0.17 Published 2007 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 17883902 Disease Relevance 0.07 Pain Relevance 0.12
S activity (Fig. 10).Fig. 10Activity of the pS2 promoter in vivo and its dependence on the rpoS gene function.
Positive_regulation (dependence) of pS2 associated with addiction
8) Confidence 0.04 Published 2010 Journal Mol Genet Genomics Section Body Doc Link PMC2939334 Disease Relevance 0.16 Pain Relevance 0.08

General Comments

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