INT9476

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Context Info
Confidence 0.43
First Reported 1992
Last Reported 2010
Negated 1
Speculated 2
Reported most in Abstract
Documents 14
Total Number 16
Disease Relevance 4.25
Pain Relevance 7.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Jun) aging (Jun) nucleus (Jun)
DNA binding (Jun) transcription factor binding (Jun)
Anatomy Link Frequency
brain 6
astrocytes 4
trigeminal ganglion 3
medulla 2
spinal cord 2
Jun (Rattus norvegicus)
Pain Link Frequency Relevance Heat
electroacupuncture 24 100.00 Very High Very High Very High
Clonidine 14 100.00 Very High Very High Very High
qutenza 9 100.00 Very High Very High Very High
Opioid 7 100.00 Very High Very High Very High
trigeminal ganglion 6 100.00 Very High Very High Very High
addiction 3 99.36 Very High Very High Very High
Morphine 15 99.10 Very High Very High Very High
Spinal cord 13 98.84 Very High Very High Very High
withdrawal 4 98.76 Very High Very High Very High
Pain 6 98.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 6 100.00 Very High Very High Very High
Opiate Addiction 1 99.36 Very High Very High Very High
Hypotension 6 98.90 Very High Very High Very High
Headache 4 97.72 Very High Very High Very High
Nociception 2 97.08 Very High Very High Very High
Brain Injury 8 96.84 Very High Very High Very High
Hyperalgesia 6 95.44 Very High Very High Very High
Morphine Dependence 2 93.96 High High
Stress 6 89.12 High High
Drug Dependence 1 87.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Phosphorylation of ERK significantly increased but there were no significant effects on cortical expression of ERK, Jun and p-38.
Neg (no) Regulation (effects) of Gene_expression (expression) of Jun
1) Confidence 0.43 Published 2005 Journal Neurosci. Lett. Section Abstract Doc Link 16024175 Disease Relevance 0.68 Pain Relevance 0.12
Application of morphine prior to noxious stimulation differentially modulates expression of Fos, Jun and Krox-24 proteins in rat spinal cord neurons.
Regulation (modulates) of Gene_expression (expression) of Jun in spinal cord neurons associated with narcan, spinal cord and morphine
2) Confidence 0.42 Published 1994 Journal Neuroscience Section Title Doc Link 8152542 Disease Relevance 0 Pain Relevance 0.92
In this paper, we attempted to investigate whether the transcription factors regulating the gene expression of c-fos and nNOS, including activator protein-1 (AP-1), nuclear factor kappa B (NF-kappa B), and octamer factors (Oct), are activated by CFA during the development of hyperalgesia.
Spec (whether) Regulation (regulating) of Gene_expression (expression) of AP-1 associated with hyperalgesia and freund adjuvant
3) Confidence 0.38 Published 2000 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10940358 Disease Relevance 0.26 Pain Relevance 0.56
The present study investigated the effect of clonidine on the basal and inducible c-jun and c-fos mRNA expression in the nucleus tractus solitarius (middle, mNTS, and rostral, rNTS) and the rostral ventrolateral medulla (caudal, cRVLM, and rostral, rRVLM).
Spec (investigated) Regulation (effect) of Gene_expression (expression) of c-jun in medulla associated with rostral ventrolateral medulla and clonidine
4) Confidence 0.37 Published 2000 Journal Brain Res. Section Abstract Doc Link 10677633 Disease Relevance 0.05 Pain Relevance 0.49
These findings establish a causal link between clonidine inhibition of c-fos expression in brainstem and its hypotensive action, and provide the first evidence that clonidine attenuates the expression of the closely linked c-jun gene in neurons implicated in centrally mediated hypotension.
Regulation (attenuates) of Gene_expression (expression) of c-jun in neurons associated with medulla, hypotension and clonidine
5) Confidence 0.27 Published 2000 Journal Brain Res. Section Abstract Doc Link 10677633 Disease Relevance 0.29 Pain Relevance 0.70
The present work was designed (a) to study comparatively the effect of 2Hz and 100Hz electroacupuncture (EA) on the expression of oncogene c-fos/c-jun and three opioid (preproenkephalin-PPE; preprodynorphin-PPD; proopiomelanocortin-POMC) genes in the rat brain; (b) to clarify the role of Fos/Jun (AP-1) on opioid genes expression induced by EA stimulation through specific blockade of EA-induced Fos/Jun expression using antisense oligodeoxynucleotides (ODNs) of c-fos/c-jun.
Regulation (effect) of Gene_expression (expression) of jun in brain associated with opioid and electroacupuncture
6) Confidence 0.26 Published 1996 Journal Sheng Li Ke Xue Jin Zhan Section Abstract Doc Link 9592236 Disease Relevance 0 Pain Relevance 0.68
The present work was designed (a) to study comparatively the effect of 2Hz and 100Hz electroacupuncture (EA) on the expression of oncogene c-fos/c-jun and three opioid (preproenkephalin-PPE; preprodynorphin-PPD; proopiomelanocortin-POMC) genes in the rat brain; (b) to clarify the role of Fos/Jun (AP-1) on opioid genes expression induced by EA stimulation through specific blockade of EA-induced Fos/Jun expression using antisense oligodeoxynucleotides (ODNs) of c-fos/c-jun.
Regulation (role) of Gene_expression (expression) of jun in brain associated with opioid and electroacupuncture
7) Confidence 0.26 Published 1996 Journal Sheng Li Ke Xue Jin Zhan Section Abstract Doc Link 9592236 Disease Relevance 0 Pain Relevance 0.75
Effects of eletriptan on the peptidergic innervation of the cerebral dura mater and trigeminal ganglion, and on the expression of c-fos and c-jun in the trigeminal complex of the rat in an experimental migraine model.
Regulation (Effects) of Gene_expression (expression) of c-jun in trigeminal ganglion associated with ganglion cysts, migraine and trigeminal ganglion
8) Confidence 0.25 Published 2000 Journal Eur. J. Neurosci. Section Title Doc Link 11069595 Disease Relevance 0.61 Pain Relevance 0.63
We show that pre- or post-treatment of capsaicin relative to MNNG administration up- or down-regulates (depending on the organ) c-jun expression in a consistent pattern in most organs.
Regulation (depending) of Gene_expression (expression) of c-jun associated with qutenza
9) Confidence 0.24 Published 1999 Journal Cancer Lett. Section Abstract Doc Link 10463771 Disease Relevance 0.26 Pain Relevance 0.52
Naloxone-precipitated morphine withdrawal, a model of opioid dependence, induces brain region-specific changes in activator protein-1 (AP-1) transcription factor gene expression.
Regulation (changes) of Gene_expression (expression) of AP-1 in brain associated with addiction, narcan, opioid, withdrawal and morphine
10) Confidence 0.23 Published 1995 Journal Mol. Pharmacol. Section Abstract Doc Link 7838131 Disease Relevance 0.50 Pain Relevance 0.82
In addition, AP-1 expression or CREB phosphorylation appears not to be involved the potentiative action of DEX on proENK mRNA expression in CTX- and PTX-treated astrocytes.
Regulation (involved) of Gene_expression (expression) of AP-1 in astrocytes
11) Confidence 0.23 Published 2001 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 11295234 Disease Relevance 0.15 Pain Relevance 0
The effect of a single injection of caffeine on the expression of c-fos, c-jun, junB, and junD, on activator protein 1 (AP-1) and on the levels of preproenkephalin mRNA in rat striatum was studied.
Regulation (effect) of Gene_expression (expression) of c-jun in striatum
12) Confidence 0.23 Published 1995 Journal J. Neurosci. Section Abstract Doc Link 7751931 Disease Relevance 0 Pain Relevance 0
In the lumbar tract of the spinal cord, higher levels of activated PKCgamma, ERK 1,2, p38, SAP/JNK and c-Jun proteins were detected in the ipsilateral side in respect of sham.
Regulation (detected) of Gene_expression (detected) of c-Jun in spinal cord associated with spinal cord
13) Confidence 0.22 Published 2010 Journal Neuroscience Section Abstract Doc Link 19925851 Disease Relevance 0.53 Pain Relevance 0.67
The effect of phorbol-12-myristate-13-acetate (PMA) on the regulation of proenkephalin (proENK) mRNA level, ENKCRE-2 or AP-1 DNA binding activity, and the mRNA and protein levels of proto-oncogenes (c-fos, fra-1, and c-jun) in primary cultured rat astrocytes were studied.
Regulation (effect) of Gene_expression (levels) of c-jun in astrocytes
14) Confidence 0.19 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9555062 Disease Relevance 0 Pain Relevance 0
The present paper describes the effect of capsaicin-induced stressful stimulus on the expression of immediate early genes (IEGs) c-fos, c-jun, junB and junD in the hypothalamic paraventricular nucleus (PVN) and the central amygdaloid nucleus (ACe) using in situ hybridization.
Regulation (effect) of Gene_expression (expression) of c-jun in nucleus associated with qutenza
15) Confidence 0.16 Published 1992 Journal Neuroreport Section Abstract Doc Link 1421086 Disease Relevance 0.30 Pain Relevance 0.13
Effects of eletriptan on the peptidergic innervation of the cerebral dura mater and trigeminal ganglion, and on the expression of c-fos and c-jun in the trigeminal complex of the rat in an experimental migraine model.
Regulation (Effects) of in dura mater Gene_expression (expression) of c-jun in trigeminal ganglion associated with ganglion cysts, migraine and trigeminal ganglion
16) Confidence 0.09 Published 2000 Journal Eur. J. Neurosci. Section Title Doc Link 11069595 Disease Relevance 0.61 Pain Relevance 0.63

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