INT9477

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Context Info
Confidence 0.45
First Reported 1992
Last Reported 2001
Negated 0
Speculated 1
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 0.88
Pain Relevance 1.15

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nucleolus (Junb) nucleus (Junb) DNA binding (Junb)
Anatomy Link Frequency
brain 6
IMG 2
nucleus 2
Junb (Rattus norvegicus)
Pain Link Frequency Relevance Heat
halothane 12 100.00 Very High Very High Very High
qutenza 7 100.00 Very High Very High Very High
anesthesia 3 100.00 Very High Very High Very High
primary afferent fibers 2 70.56 Quite High
Neurotransmitter 1 63.84 Quite High
opioid receptor 4 50.00 Quite Low
Somatostatin 1 25.44 Quite Low
addiction 2 5.00 Very Low Very Low Very Low
tolerance 1 5.00 Very Low Very Low Very Low
Opioid 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 10 99.70 Very High Very High Very High
Colitis 3 96.16 Very High Very High Very High
Stress 4 89.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Selective effects of pentobarbital and halothane on c-fos and jun-B gene expression in rat brain.
Regulation (effects) of Gene_expression (expression) of jun-B in brain associated with halothane
1) Confidence 0.45 Published 1992 Journal Anesthesiology Section Title Doc Link 1642355 Disease Relevance 0 Pain Relevance 0.28
Selective effects of pentobarbital and halothane on c-fos and jun-B gene expression in rat brain.
Regulation (effects) of Gene_expression (expression) of jun-B in brain associated with halothane
2) Confidence 0.45 Published 1992 Journal Anesthesiology Section Title Doc Link 1642355 Disease Relevance 0 Pain Relevance 0.28
The effects of pentobarbital and halothane anesthesia on the expression in brain of the immediate-early genes c-fos and jun-B were investigated.
Spec (investigated) Regulation (effects) of Gene_expression (expression) of jun-B in brain associated with anesthesia and halothane
3) Confidence 0.45 Published 1992 Journal Anesthesiology Section Abstract Doc Link 1642355 Disease Relevance 0 Pain Relevance 0.26
The present paper describes the effect of capsaicin-induced stressful stimulus on the expression of immediate early genes (IEGs) c-fos, c-jun, junB and junD in the hypothalamic paraventricular nucleus (PVN) and the central amygdaloid nucleus (ACe) using in situ hybridization.
Regulation (effect) of Gene_expression (expression) of junB in nucleus associated with qutenza
4) Confidence 0.39 Published 1992 Journal Neuroreport Section Abstract Doc Link 1421086 Disease Relevance 0.30 Pain Relevance 0.13
Activation of neurons in the inferior mesenteric ganglion (IMG) was assessed using c-fos, JunB, and c-Jun expression in the guinea pig IMG and colonic myenteric plexus during mechanosensory stimulation and acute colitis in normal and capsaicin-treated animals.
Regulation (using) of in IMG Gene_expression (expression) of JunB in inferior mesenteric ganglion associated with colitis, ganglion cysts and qutenza
5) Confidence 0.20 Published 1999 Journal J. Neurosci. Section Abstract Doc Link 10087087 Disease Relevance 0.58 Pain Relevance 0.20
Electrophoretic mobility shift assay revealed that AP-1 binding activity in the nuclear extract was elevated by MOR activation and further showed that products of c-fos and junB genes are involved in formation of AP-1 complex.
Regulation (involved) of Gene_expression (products) of junB
6) Confidence 0.11 Published 2001 Journal Anesthesiology Section Body Doc Link 11605942 Disease Relevance 0 Pain Relevance 0

General Comments

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