INT94772

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Context Info
Confidence 0.75
First Reported 2001
Last Reported 2010
Negated 5
Speculated 1
Reported most in Body
Documents 14
Total Number 15
Disease Relevance 8.25
Pain Relevance 2.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Cdkn2a) aging (Cdkn2a) DNA binding (Cdkn2a)
protein complex (Cdkn2a) cytoplasm (Cdkn2a) nucleolus (Cdkn2a)
Anatomy Link Frequency
urine 3
RG2 2
hepatocyte 1
neurons 1
nerve 1
Cdkn2a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
inferior alveolar nerve 151 99.84 Very High Very High Very High
metalloproteinase 6 99.62 Very High Very High Very High
Nerve growth factor 4 98.20 Very High Very High Very High
trigeminal ganglion 66 97.40 Very High Very High Very High
fifth nerve 2 87.08 High High
opioid receptor 4 86.92 High High
allodynia 5 86.16 High High
antagonist 14 77.52 Quite High
palliative 1 77.28 Quite High
adenocard 5 76.08 Quite High
Disease Link Frequency Relevance Heat
Acute Renal Failure 196 100.00 Very High Very High Very High
Necrosis 9 100.00 Very High Very High Very High
Glioma 24 99.70 Very High Very High Very High
Ganglion Cysts 71 98.60 Very High Very High Very High
Glioblastoma 76 98.36 Very High Very High Very High
Renal Disease 36 97.92 Very High Very High Very High
Apoptosis 255 97.00 Very High Very High Very High
Renal Insufficiency 4 93.00 High High
Hepatocellular Cancer 41 90.84 High High
Pancreatic Cancer 9 89.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
At the same time point, expression of cyclin-dependent kinase inhibitor p16INK4 (CDKN2A) was upregulated (Table 2).
Gene_expression (expression) of p16INK4
1) Confidence 0.75 Published 2004 Journal J Carcinog Section Body Doc Link PMC421747 Disease Relevance 0.06 Pain Relevance 0
The possibility that the release of both IL-6 and NGF may be involved in the observed generation of ectopic discharges from injured IAN fibers lacking a RF is also supported by our findings that approximately a half of the TG neurons were unlabeled with FG at 14 days after IAN transection (Figure 1C).
Neg (lacking) Gene_expression (lacking) of a RF is in neurons associated with inferior alveolar nerve, nerve growth factor and trigeminal ganglion
2) Confidence 0.65 Published 2010 Journal Mol Pain Section Body Doc Link PMC2829527 Disease Relevance 0.66 Pain Relevance 0.79
Also DOR-IR and MOR-IR were detected at P8 and P16 in nerve fibers within the spiral ganglion.
Gene_expression (detected) of P16 in nerve associated with ganglion cysts
3) Confidence 0.63 Published 2003 Journal Hear. Res. Section Abstract Doc Link 14553898 Disease Relevance 0.19 Pain Relevance 0.26
However, ARF and acute tubular necrosis continue to be clinically frustrating entities from both the diagnostic and therapeutic standpoints (22).
Gene_expression (necrosis) of ARF associated with necrosis and acute renal failure
4) Confidence 0.61 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2779283 Disease Relevance 0.96 Pain Relevance 0.22
Four of these 10 PanIN specimens (40%), but none of the 20 non-PanIN tissues, revealed a loss of p16 expression in immunohistochemistry.
Gene_expression (expression) of p16
5) Confidence 0.56 Published 2001 Journal Surgery Section Body Doc Link 11283541 Disease Relevance 0.13 Pain Relevance 0
The present study has some limitations; 1) the number of animals used was small, 2) the rat ARF model may not well reflect human ARF, 3) creatinine levels were not constant after ARF and may depend on individual animal condition, 4) GFR was not calculated because urine creatinine levels were not measured, 5) the discrepancy between the creatinine levels and the degree of apoptosis observed in the two groups cannot be explained by proposed renal damage mechanism.
Gene_expression (model) of ARF in urine associated with acute renal failure and apoptosis
6) Confidence 0.54 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2779283 Disease Relevance 0.89 Pain Relevance 0.21
The present study has some limitations; 1) the number of animals used was small, 2) the rat ARF model may not well reflect human ARF, 3) creatinine levels were not constant after ARF and may depend on individual animal condition, 4) GFR was not calculated because urine creatinine levels were not measured, 5) the discrepancy between the creatinine levels and the degree of apoptosis observed in the two groups cannot be explained by proposed renal damage mechanism.
Neg (not) Gene_expression (reflect) of ARF in urine associated with acute renal failure and apoptosis
7) Confidence 0.54 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2779283 Disease Relevance 0.94 Pain Relevance 0.21
The present study has some limitations; 1) the number of animals used was small, 2) the rat ARF model may not well reflect human ARF, 3) creatinine levels were not constant after ARF and may depend on individual animal condition, 4) GFR was not calculated because urine creatinine levels were not measured, 5) the discrepancy between the creatinine levels and the degree of apoptosis observed in the two groups cannot be explained by proposed renal damage mechanism.
Neg (not) Gene_expression (constant) of ARF in urine associated with acute renal failure and apoptosis
8) Confidence 0.54 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2779283 Disease Relevance 0.94 Pain Relevance 0.20
Pancreatic intraductal neoplasias (PanIN) were identified in hematoxylin-and-eosin-stained slides. p16 protein expression was investigated immunohistochemically in all specimens.
Spec (investigated) Gene_expression (expression) of p16
9) Confidence 0.49 Published 2001 Journal Surgery Section Body Doc Link 11283541 Disease Relevance 0.18 Pain Relevance 0
, hepatocyte growth factor and c-met, c-ErbB-2, u-plasminogen activator, MXR7, MDM2, MAGE, matrix metalloproteinase, Smads, p53, pRB, p16INK4, p21WAF1/CIP1, p27Kip1, PTEN, E-cadherin, ?
Gene_expression (/) of p16INK4 in hepatocyte associated with metalloproteinase
10) Confidence 0.29 Published 2003 Journal BMC Gastroenterol Section Body Doc Link PMC317301 Disease Relevance 1.09 Pain Relevance 0.13
Expression of the cell cycle inhibitor p16 decreased, whereas epidermal growth factor receptor expression increased in the tongue.
Gene_expression (Expression) of p16 in tongue
11) Confidence 0.20 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1821034 Disease Relevance 0.46 Pain Relevance 0
However, although RG2 cells were impaired for p53 and p16, p27 and procaspase 9 expression induced by BP were increased in these cells.
Neg (impaired) Gene_expression (impaired) of p16 in RG2
12) Confidence 0.10 Published 2006 Journal Journal of Neurochemistry Section Body Doc Link PMC1804119 Disease Relevance 0.60 Pain Relevance 0.03
Levels of p16, p21, Bax and AIF protein in BP-treated GBM cells were therefore measured, and protein expression levels of all four proteins increased in DBTRG-05MG and DBTRG 8401 cells; similar results for p27, Bax and AIF were detected in RG2 cells after treatment with BP (Figs 2b and c).
Gene_expression (Levels) of p16 in RG2 associated with glioblastoma
13) Confidence 0.09 Published 2006 Journal Journal of Neurochemistry Section Body Doc Link PMC1804119 Disease Relevance 0.49 Pain Relevance 0
C6 glioma cells did not express the cyclin-dependent kinase inhibitor p16 (data not shown) as previously reported [30].
Neg (not) Gene_expression (express) of p16 associated with glioma
14) Confidence 0.08 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2661078 Disease Relevance 0.66 Pain Relevance 0
In addition, allelic losses of tumor suppressor genes p16 (INK4, CDKN2A) and DPC4 (MADH4, SMAD4) were detected by monitoring the loss of heterozygosity (LOH) at 9p and 18q, respectively.
Gene_expression (detected) of CDKN2A
15) Confidence 0.04 Published 2007 Journal World J. Gastroenterol. Section Body Doc Link 17659731 Disease Relevance 0 Pain Relevance 0

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