INT94773

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Context Info
Confidence 0.41
First Reported 2001
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.65
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Cdkn2a) aging (Cdkn2a) DNA binding (Cdkn2a)
protein complex (Cdkn2a) cytoplasm (Cdkn2a) nucleolus (Cdkn2a)
Anatomy Link Frequency
tongue 2
Cdkn2a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 18 50.00 Quite Low
Chronic pancreatitis 2 50.00 Quite Low
aspirin 5 5.00 Very Low Very Low Very Low
Inflammation 5 5.00 Very Low Very Low Very Low
cINOD 4 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
COX2 1 5.00 Very Low Very Low Very Low
adenocard 1 5.00 Very Low Very Low Very Low
metalloproteinase 1 5.00 Very Low Very Low Very Low
tolerance 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Malignant Neoplastic Disease 6 85.60 High High
Mouth Cancer 6 81.76 Quite High
Cancer 59 76.24 Quite High
Skin Cancer 26 73.64 Quite High
Pancreatic Cancer 4 68.12 Quite High
Colon Cancer 40 50.00 Quite Low
Pancreatitis 2 50.00 Quite Low
Pneumonia 2 36.64 Quite Low
Gastroenteritis 2 35.60 Quite Low
Appetite Loss 1 19.76 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
At the same time point, expression of cyclin-dependent kinase inhibitor p16INK4 (CDKN2A) was upregulated (Table 2).
Negative_regulation (inhibitor) of Gene_expression (expression) of p16INK4
1) Confidence 0.41 Published 2004 Journal J Carcinog Section Body Doc Link PMC421747 Disease Relevance 0.06 Pain Relevance 0
Four of these 10 PanIN specimens (40%), but none of the 20 non-PanIN tissues, revealed a loss of p16 expression in immunohistochemistry.
Negative_regulation (loss) of Gene_expression (expression) of p16
2) Confidence 0.31 Published 2001 Journal Surgery Section Body Doc Link 11283541 Disease Relevance 0.13 Pain Relevance 0
Expression of the cell cycle inhibitor p16 decreased, whereas epidermal growth factor receptor expression increased in the tongue.
Negative_regulation (decreased) of Gene_expression (Expression) of p16 in tongue
3) Confidence 0.15 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1821034 Disease Relevance 0.46 Pain Relevance 0

General Comments

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