INT9478

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Context Info
Confidence 0.70
First Reported 1992
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 19
Total Number 19
Disease Relevance 2.34
Pain Relevance 7.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Junb) nucleus (Junb) DNA binding (Junb)
Anatomy Link Frequency
ACe 8
striatum 6
brain 2
CPu 2
forebrain 2
Junb (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 8 100.00 Very High Very High Very High
Morphine 43 99.98 Very High Very High Very High
withdrawal 6 99.56 Very High Very High Very High
addiction 12 99.28 Very High Very High Very High
Raphe 2 99.20 Very High Very High Very High
Neurotransmitter 6 99.16 Very High Very High Very High
Central grey 4 98.76 Very High Very High Very High
antagonist 19 98.12 Very High Very High Very High
Physical dependence 1 96.28 Very High Very High Very High
Serotonin 9 96.24 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 17 99.98 Very High Very High Very High
Urological Neuroanatomy 4 98.76 Very High Very High Very High
Drug Dependence 3 96.28 Very High Very High Very High
Opiate Addiction 1 95.44 Very High Very High Very High
Morphine Dependence 2 90.68 High High
Cognitive Disorder 1 81.28 Quite High
Aids-related Complex 1 71.28 Quite High
Sleep Disorders 2 49.88 Quite Low
Amnesia 4 48.92 Quite Low
Recurrence 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Morphine also induced JunB expression in the same region of the dorsomedial CPu.
Positive_regulation (induced) of Gene_expression (expression) of JunB in CPu associated with morphine
1) Confidence 0.70 Published 1998 Journal Brain Res. Section Abstract Doc Link 9838105 Disease Relevance 0 Pain Relevance 1.04
At 1 mg/kg, MDL 72222 both induced JunB expression and potentiated the response induced by morphine.
Positive_regulation (induced) of Gene_expression (expression) of JunB associated with morphine
2) Confidence 0.70 Published 1998 Journal Brain Res. Section Abstract Doc Link 9838105 Disease Relevance 0 Pain Relevance 1.04
To determine if the periaqueductal gray (PAG) and the dorsal raphe nucleus (DRN) are involved in morphine-induced c-Fos and JunB expression in the caudate-putamen (CPu), the mu receptor antagonist, beta-funaltrexamine (beta-FNA), was unilaterally infused into the PAG adjacent to DRN prior to morphine.
Positive_regulation (induced) of Gene_expression (expression) of JunB in DRN associated with antagonist, raphe, central grey and morphine
3) Confidence 0.66 Published 1999 Journal Brain Res. Section Abstract Doc Link 10526114 Disease Relevance 0.29 Pain Relevance 0.96
Stress caused an intense expression of c-fos, c-jun and junB especially in the PVN and ACe and also a clear induction of junD was observed in the PVN.
Positive_regulation (caused) of Gene_expression (expression) of junB in ACe associated with stress
4) Confidence 0.61 Published 1992 Journal Neuroreport Section Abstract Doc Link 1421086 Disease Relevance 0.34 Pain Relevance 0.13
The present results demonstrate that neurotransmitters released from splanchnic nerve terminals induce expression of c-fos, c-jun, and junB in adrenal chromaffin cells which results in increased AP-1 DNA binding activity.
Positive_regulation (induce) of Gene_expression (expression) of junB associated with neurotransmitter
5) Confidence 0.48 Published 1995 Journal J. Neurosci. Section Abstract Doc Link 7891139 Disease Relevance 0 Pain Relevance 0.58
Increased expression of c-jun, junB, AP-1, and preproenkephalin mRNA in rat striatum following a single injection of caffeine.
Positive_regulation (Increased) of Gene_expression (expression) of junB in striatum associated with enkephalin
6) Confidence 0.47 Published 1995 Journal J. Neurosci. Section Title Doc Link 7751931 Disease Relevance 0 Pain Relevance 0.13
Increased expression of c-jun, junB, AP-1, and preproenkephalin mRNA in rat striatum following a single injection of caffeine.
Positive_regulation (following) of Gene_expression (expression) of junB in striatum associated with enkephalin
7) Confidence 0.47 Published 1995 Journal J. Neurosci. Section Title Doc Link 7751931 Disease Relevance 0 Pain Relevance 0.13
Stress caused an intense expression of c-fos, c-jun and junB especially in the PVN and ACe and also a clear induction of junD was observed in the PVN.
Positive_regulation (intense) of Gene_expression (expression) of junB in ACe associated with stress
8) Confidence 0.44 Published 1992 Journal Neuroreport Section Abstract Doc Link 1421086 Disease Relevance 0.34 Pain Relevance 0.13
Acute injection of morphine induces expression of the immediate-early genes c-Fos and JunB in several forebrain regions of the rat, in part through an N-methyl-D-aspartate (NMDA) receptor-dependent mechanism.
Positive_regulation (induces) of Gene_expression (expression) of JunB in forebrain associated with morphine
9) Confidence 0.39 Published 2003 Journal Neuroscience Section Abstract Doc Link 12809699 Disease Relevance 0 Pain Relevance 0.51
In contrast, Kozinn and co-workers showed that propofol regulates the expression of c-Fos in hippocampal slices via inhibition of N-methyl-D-aspartate (NMDA) receptor activation of the extracellular signal-regulated kinase (ERK) pathway [14,15], while Hamaya et al reported that propofol increases the expression of c-Fos and Jun B in the rat brain [16].
Positive_regulation (increases) of Gene_expression (expression) of Jun B in brain
10) Confidence 0.33 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2916009 Disease Relevance 0.07 Pain Relevance 0.36
Rapid increases in c-fos, fos-B, jun-B, and c-jun mRNA levels accompany withdrawal, with the relative level of induction correlating with the severity of physical dependence.
Positive_regulation (increases) of Gene_expression (levels) of jun-B associated with physical dependence and withdrawal
11) Confidence 0.26 Published 1995 Journal Mol. Pharmacol. Section Abstract Doc Link 7838131 Disease Relevance 0.51 Pain Relevance 0.81
Stress caused an intense expression of c-fos, c-jun and junB especially in the PVN and ACe and also a clear induction of junD was observed in the PVN.
Positive_regulation (caused) of in PVN Gene_expression (expression) of junB in ACe associated with stress
12) Confidence 0.21 Published 1992 Journal Neuroreport Section Abstract Doc Link 1421086 Disease Relevance 0.34 Pain Relevance 0.13
Our results demonstrated that d-fenfluramine evokes nuclear expression of Fos/Jun B proteins in the striatum, and that the Fos expression was dose-dependent and accompanied by transient induction of c-fos mRNA.
Positive_regulation (evokes) of Gene_expression (expression) of Jun B in striatum
13) Confidence 0.18 Published 2000 Journal J. Neurochem. Section Abstract Doc Link 10737591 Disease Relevance 0 Pain Relevance 0.26
These results suggest that the mechanism by which d-fenfluramine induces c-fos and jun B expression in the rat caudoputamen depends at least in part on activation of the dopaminergic system by serotonin.
Positive_regulation (induces) of Gene_expression (expression) of jun B associated with serotonin
14) Confidence 0.18 Published 2000 Journal J. Neurochem. Section Abstract Doc Link 10737591 Disease Relevance 0 Pain Relevance 0.35
Stress caused an intense expression of c-fos, c-jun and junB especially in the PVN and ACe and also a clear induction of junD was observed in the PVN.
Positive_regulation (intense) of in PVN Gene_expression (expression) of junB in ACe associated with stress
15) Confidence 0.15 Published 1992 Journal Neuroreport Section Abstract Doc Link 1421086 Disease Relevance 0.34 Pain Relevance 0.13
However, a more direct approach, investigating expression of putative hibernation-responsive genes by Northern analysis, revealed an increase in expression of transcription factors c-fos, junB, and c-Jun, but not junD, commencing during late torpor and peaking during the arousal phase of individual hibernation bouts.
Positive_regulation (increase) of Gene_expression (expression) of junB
16) Confidence 0.15 Published 1999 Journal J. Neurosci. Section Abstract Doc Link 10234010 Disease Relevance 0 Pain Relevance 0.14
CONCLUSIONS: Mu-opioid receptor activation induces c-fos and junB expression and elevates AP-1-mediated transcriptional activities via the mitogen-activated protein kinase cascade.


Positive_regulation (induces) of Gene_expression (expression) of junB
17) Confidence 0.12 Published 2001 Journal Anesthesiology Section Body Doc Link 11605942 Disease Relevance 0 Pain Relevance 0
Amphetamine can induce the expression of c-Fos and jun-B and zif:268.
Positive_regulation (induce) of Gene_expression (expression) of jun-B
18) Confidence 0.10 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2567327 Disease Relevance 0.09 Pain Relevance 0.59
In addition, the activation of both the p38 and ERK pathways appears to be involved in the AA-induced increase of proENK mRNA via activating the expression of proto-oncoprotein, such as Fra-1, Fra-2, c-Jun, and JunB.
Positive_regulation (activating) of Gene_expression (expression) of JunB
19) Confidence 0.09 Published 2000 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 10762717 Disease Relevance 0 Pain Relevance 0

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