INT94784

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Context Info
Confidence 0.40
First Reported 2001
Last Reported 2011
Negated 3
Speculated 4
Reported most in Body
Documents 113
Total Number 117
Disease Relevance 71.57
Pain Relevance 10.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (ROS1) cell proliferation (ROS1) plasma membrane (ROS1)
Anatomy Link Frequency
spermatozoa 2
liver 2
ventricle 1
nerve fiber bundles 1
macrophages 1
ROS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 1938 100.00 Very High Very High Very High
cytokine 924 99.92 Very High Very High Very High
Arthritis 133 99.76 Very High Very High Very High
ischemia 98 99.68 Very High Very High Very High
Nicotine 92 99.64 Very High Very High Very High
Paracetamol 43 99.52 Very High Very High Very High
cocaine 876 99.28 Very High Very High Very High
Dopamine 39 99.08 Very High Very High Very High
antagonist 132 99.04 Very High Very High Very High
Spinal cord 108 99.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 3387 100.00 Very High Very High Very High
INFLAMMATION 2132 100.00 Very High Very High Very High
Hypoxia 370 100.00 Very High Very High Very High
Toxicity 302 99.98 Very High Very High Very High
Death 1338 99.92 Very High Very High Very High
Nicotine Addiction 182 99.84 Very High Very High Very High
Disease 977 99.80 Very High Very High Very High
Parkinson's Disease 51 99.80 Very High Very High Very High
Arthritis 194 99.76 Very High Very High Very High
Cv Unclassified Under Development 140 99.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings and those of others reported in the literature indicate reciprocal interactions between TRPV1 and ROS play critical roles in the pathological and nociceptive responses active during arthritic inflammation.


ROS Binding (interactions) of
1) Confidence 0.40 Published 2010 Journal Mol Pain Section Body Doc Link 20691059 Disease Relevance 0 Pain Relevance 0
Emerging evidence indicates that pancreatitis-inducing ROS/RNS generation may be attenuated by targeting ROS/RNS-generating enzymes and upstream mediators.
ROS Binding (targeting) of associated with pancreatitis
2) Confidence 0.36 Published 2009 Journal Antioxid. Redox Signal. Section Abstract Doc Link 18837654 Disease Relevance 0.56 Pain Relevance 0.27
Signaling in neurons based on formation and release of ROS and RNS is produced through reversible modification of redox-sensitive sites on target proteins, such as ryanodine receptors (RyRs) (Hidalgo, 2005; Huddleston et al., 2008).
ROS Binding (formation) of in neurons
3) Confidence 0.34 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2874397 Disease Relevance 0.07 Pain Relevance 0.19
Furthermore, decreased mitochondrial ROS formation during ischemia and reperfusion in hearts preconditioned by volatile anesthetics might underlie the improved postischemic structure and function.
ROS Spec (might) Binding (formation) of in hearts associated with ischemia
4) Confidence 0.31 Published 2004 Journal Antioxid. Redox Signal. Section Abstract Doc Link 15025946 Disease Relevance 0.21 Pain Relevance 0.11
They can also act directly by suppressing ROS formation (30).


ROS Binding (formation) of
5) Confidence 0.30 Published 2006 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1697746 Disease Relevance 0.77 Pain Relevance 0.05
How ROS and other oxidative stress-related reactive intermediates interact with biological macromolecules
ROS Binding (interact) of associated with stress
6) Confidence 0.29 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 0.63 Pain Relevance 0
OS can be overcome by reducing generation of ROS or increasing the amounts of antioxidants available.
ROS Binding (generation) of associated with stress
7) Confidence 0.27 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1215514 Disease Relevance 0.73 Pain Relevance 0.07
As our understanding the role ROS-induced angiogenesis plays in atherosclerosis and myocardial angiogenesis grows, future studies should investigate the role ROS plays in the angiogenesis in the female reproductive tract.

2.4 Reactive oxygen species and the endometrium

ROS Binding (understanding) of in endometrium associated with increased venous pressure under development
8) Confidence 0.27 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1215514 Disease Relevance 0.47 Pain Relevance 0.11
Carotenoids have gained attention because they are similar to vitamin E in that they are very potent antioxidants and react with ROS; the presence of carotenoids has been demonstrated in the follicular fluid [163].
ROS Binding (react) of
9) Confidence 0.26 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1215514 Disease Relevance 0.40 Pain Relevance 0
Numerous animal and human studies have demonstrated the presence of ROS in the female reproductive tract: ovaries, [11-15], fallopian tubes [16] and embryos [17].
ROS Binding (presence) of in female reproductive tract
10) Confidence 0.26 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1215514 Disease Relevance 0.27 Pain Relevance 0
The effects of NO are proposed to be mediated through cGMP as a second messenger or by generation of ROS resulting from interaction of NO with superoxide radicals [111].
ROS Neg (NO) Binding (interaction) of
11) Confidence 0.26 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1215514 Disease Relevance 0 Pain Relevance 0
Alterations of mitochondria have a role in different types of either caspase-dependent or caspase-independent cell death [196] and are strictly associated with ROS.
ROS Binding (associated) of associated with death
12) Confidence 0.26 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 0.86 Pain Relevance 0
ROS and other pro-oxidants can interact with virtually any macromolecule of biological interest.
ROS Binding (interact) of
13) Confidence 0.26 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 0.48 Pain Relevance 0
By interacting with polyunsaturated fatty acids in membrane phospholipids, ROS and reactive pro-oxidants can elicit peroxidation of lipids and their subsequent degradation and fragmentation.
ROS Binding (interacting) of
14) Confidence 0.26 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 0.42 Pain Relevance 0
ROS generation in spermatozoa
ROS Binding (generation) of in spermatozoa
15) Confidence 0.25 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1315356 Disease Relevance 0.58 Pain Relevance 0
Human spermatozoa are capable of generating ROS and this activity is of physiological significance in promoting the tyrosine phosphorylation events associated with sperm capacitation.
ROS Binding (generating) of in sperm
16) Confidence 0.25 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1315356 Disease Relevance 0.45 Pain Relevance 0
Reactive oxygen species (ROS), generated by reduction-oxidation (redox) reactions, have been recognized as important chemical mediators that regulate signal transduction.
ROS Binding (recognized) of
17) Confidence 0.25 Published 2001 Journal J. Med. Invest. Section Abstract Doc Link 11286012 Disease Relevance 0.48 Pain Relevance 0.08
During hypoxia, reduced ROS formation serves to activate HIF-1?
ROS Binding (formation) of associated with hypoxia
18) Confidence 0.22 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC1064874 Disease Relevance 0.82 Pain Relevance 0.15
When interacting with proteins, ROS may lead to: (a) oxidation of critical amino acid residues, for example, the thiol group of cysteine; (b) formation of intra-molecular disulfide bonds (-S-S-); (c) thiol/disulfide changes leading to either formation or disruption of inter-molecular disulfide bonds between homo- or hetero-dimers; (d) formation of di-tyrosine and protein cross-linking; and (e) iron and copper metal ions can lead to the formation of OH radicals in a Fenton reaction – this can extensively damage target proteins, leading to their ubiquitination and proteasomal degradation.
ROS Binding (interacting) of
19) Confidence 0.22 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 0.38 Pain Relevance 0
These findings and those of others reported in the literature indicate reciprocal interactions between TRPV1 and ROS play critical roles in the pathological and nociceptive responses active during arthritic inflammation.



ROS Binding (interactions) of associated with nociception, inflammation and arthritis
20) Confidence 0.21 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC2924298 Disease Relevance 0.80 Pain Relevance 0.44

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