INT9479

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.69
First Reported 1992
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 12
Total Number 12
Disease Relevance 1.57
Pain Relevance 0.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Jund) nucleus (Jund) DNA binding (Jund)
protein complex (Jund)
Anatomy Link Frequency
ACe 2
nucleus accumbens 1
spinal cord 1
hippocampus 1
Jund (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hippocampus 6 99.84 Very High Very High Very High
Nucleus accumbens 2 99.44 Very High Very High Very High
Spinal cord 6 98.76 Very High Very High Very High
qutenza 4 86.64 High High
dexamethasone 1 85.28 High High
Neurotransmitter 2 84.24 Quite High
cytokine 15 72.08 Quite High
Enkephalin 8 25.00 Low Low
Pain 6 25.00 Low Low
Inflammation 4 22.00 Low Low
Disease Link Frequency Relevance Heat
Convulsion 7 99.08 Very High Very High Very High
Stress 11 97.96 Very High Very High Very High
Primary Sclerosing Cholangitis 43 88.60 High High
INFLAMMATION 4 22.00 Low Low
Fibrosis 45 5.00 Very Low Very Low Very Low
Pancreatitis 11 5.00 Very Low Very Low Very Low
Pancreatic Cancer 8 5.00 Very Low Very Low Very Low
Cirrhosis 7 5.00 Very Low Very Low Very Low
Injury 4 5.00 Very Low Very Low Very Low
Apoptosis 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RNA slot-blotting and hybridization techniques revealed a transcriptional activation of the junD proto-oncogene after 6 h, but not 1 h following UV exposure.
Positive_regulation (activation) of junD
1) Confidence 0.69 Published 1992 Journal Neurosci. Lett. Section Abstract Doc Link 1489400 Disease Relevance 0 Pain Relevance 0.09
These results suggest that low-frequency ongoing afferent impulse discharge is reflected by an accumulation in junD transcripts.
Positive_regulation (accumulation) of junD
2) Confidence 0.69 Published 1992 Journal Neurosci. Lett. Section Abstract Doc Link 1489400 Disease Relevance 0 Pain Relevance 0.08
Stress caused an intense expression of c-fos, c-jun and junB especially in the PVN and ACe and also a clear induction of junD was observed in the PVN.
Positive_regulation (induction) of junD in ACe associated with stress
3) Confidence 0.62 Published 1992 Journal Neuroreport Section Abstract Doc Link 1421086 Disease Relevance 0.35 Pain Relevance 0.13
No induction of junD was found.
Positive_regulation (induction) of junD
4) Confidence 0.61 Published 1995 Journal J. Neurosci. Section Abstract Doc Link 7751931 Disease Relevance 0 Pain Relevance 0.05
Here, we report that noxious cutaneous ultraviolet (UV) irradiation results in a nearly 8-fold increase in junD mRNA levels in the rat lumbar spinal cord.
Positive_regulation (increase) of junD in spinal cord associated with spinal cord
5) Confidence 0.50 Published 1992 Journal Neurosci. Lett. Section Abstract Doc Link 1489400 Disease Relevance 0 Pain Relevance 0.09
While c-Fos, Fra-2 and JunB were increased in response to either stimuli, only Fra-1, c-Jun and JunD were increased by PMA.
Positive_regulation (increased) of JunD
6) Confidence 0.46 Published 2000 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 11113530 Disease Relevance 0 Pain Relevance 0.04
A strong induction of junB, a weak induction of c-fos and c-jun, but not of junD, was seen in nucleus accumbens.
Positive_regulation (induction) of junD in nucleus accumbens associated with nucleus accumbens
7) Confidence 0.44 Published 1995 Journal J. Neurosci. Section Abstract Doc Link 7751931 Disease Relevance 0 Pain Relevance 0.05
The pre-administration with L-NAME further increased KA-induced c-jun and c-fos mRNA levels in addition to their protein product levels, although the pre-treatment with L-NAME did not affect KA-induced FosB, Fra-2, JunB, and JunD protein levels at 6 h after treatment.
Positive_regulation (induced) of JunD
8) Confidence 0.39 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9602069 Disease Relevance 0 Pain Relevance 0.07
In addition, C2 ceramide also increased AP-1 proteins, such as Fra-1, c-Jun, JunB and JunD, and phosphorylation of CREB.
Positive_regulation (increased) of JunD
9) Confidence 0.32 Published 2001 Journal Brain Res. Section Abstract Doc Link 11382404 Disease Relevance 0 Pain Relevance 0
It suggested that the AP-1 complex was composed of Fra and Jun D in hippocampus of the seizure-sensitive rats.
Positive_regulation (composed) of Jun D in hippocampus associated with convulsion and hippocampus
10) Confidence 0.23 Published 1998 Journal Sheng Li Xue Bao Section Abstract Doc Link 11324547 Disease Relevance 0.50 Pain Relevance 0.18
Stress caused an intense expression of c-fos, c-jun and junB especially in the PVN and ACe and also a clear induction of junD was observed in the PVN.
Positive_regulation (induction) of junD in PVN associated with stress
11) Confidence 0.21 Published 1992 Journal Neuroreport Section Abstract Doc Link 1421086 Disease Relevance 0.35 Pain Relevance 0.13
Further experiments revealed that phenotypic transition of PSCs towards myofibroblasts was accompanied by characteristic changes of AP-1 complex composition (increase of the JunD content relative to the one of JunB) [62].
Positive_regulation (increase) of JunD
12) Confidence 0.21 Published 2004 Journal Mol Cancer Section Body Doc Link PMC524499 Disease Relevance 0.37 Pain Relevance 0.04

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox