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Context Info
Confidence 0.42
First Reported 1979
Last Reported 1992
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.74
Pain Relevance 1.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TRH) extracellular region (TRH) plasma membrane (TRH)
nucleus (TRH) cell-cell signaling (TRH) cytoplasm (TRH)
Anatomy Link Frequency
plasma 2
TRH (Homo sapiens)
Pain Link Frequency Relevance Heat
headache 5 99.08 Very High Very High Very High
tetrodotoxin 2 97.96 Very High Very High Very High
dexamethasone 2 95.96 Very High Very High Very High
Bile 1 91.28 High High
Cholecystokinin 2 90.16 High High
substance P 1 90.16 High High
Spinal cord 2 89.28 High High
Central nervous system 1 85.08 High High
Enkephalin 1 76.88 Quite High
Cluster headache 1 75.00 Quite High
Disease Link Frequency Relevance Heat
Cluster Headache 6 99.08 Very High Very High Very High
Cancer 1 97.56 Very High Very High Very High
Cardiovascular Disease 1 75.60 Quite High
Thyroid Disease 3 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TSH response was absent after TRH and domperidone, while TSH serum levels decreased by 25% after bromocriptine.
Negative_regulation (absent) of Regulation (response) of TRH
1) Confidence 0.42 Published 1989 Journal J. Endocrinol. Invest. Section Abstract Doc Link 2592743 Disease Relevance 0.32 Pain Relevance 0.10
The effects of motilin, neurotensin, and thyrotropin-releasing hormone were greatly reduced or abolished by perfusion of the preparation with tetrodotoxin.
Negative_regulation (reduced) of Regulation (effects) of thyrotropin-releasing hormone associated with tetrodotoxin
2) Confidence 0.41 Published 1979 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 115560 Disease Relevance 0 Pain Relevance 0.54
We observed a normal dexamethasone suppression test (DST) in all patients, increased cortisol plasma levels in remission patients at 8.00am before and at the end of the DST, while only in CH patients during cluster period did we find a reduced TSH response to TRH and a reduced night-time melatonin peak.
Negative_regulation (reduced) of Regulation (response) of TRH in plasma associated with headache and dexamethasone
3) Confidence 0.41 Published 1992 Journal Ital J Neurol Sci Section Abstract Doc Link 1624279 Disease Relevance 0.42 Pain Relevance 0.64

General Comments

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