INT9480

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Context Info
Confidence 0.77
First Reported 1992
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 14
Total Number 15
Disease Relevance 3.58
Pain Relevance 5.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Jund) nucleus (Jund) DNA binding (Jund)
protein complex (Jund)
Anatomy Link Frequency
medial 3
Nerve 2
spinal cord 1
striatum 1
nucleus 1
Jund (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain 20 100.00 Very High Very High Very High
Nerve growth factor 10 100.00 Very High Very High Very High
adenocard 14 99.92 Very High Very High Very High
qutenza 2 99.30 Very High Very High Very High
Thalamus 38 99.16 Very High Very High Very High
Spinal cord 6 98.92 Very High Very High Very High
Somatostatin 4 97.16 Very High Very High Very High
c fibre 20 96.70 Very High Very High Very High
Inflammation 15 95.76 Very High Very High Very High
Dopamine 106 95.36 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 36 100.00 Very High Very High Very High
Necrosis 28 100.00 Very High Very High Very High
INFLAMMATION 14 95.76 Very High Very High Very High
Alzheimer's Dementia 16 93.92 High High
Stress 8 90.32 High High
Apoptosis 28 87.08 High High
Disease 8 80.80 Quite High
Pain 3 75.00 Quite High
Repression 6 46.88 Quite Low
Depression 26 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression of the junD proto-oncogene in the rat spinal cord and skin following noxious cutaneous ultraviolet irradiation.
Gene_expression (Expression) of junD in spinal cord associated with pain and spinal cord
1) Confidence 0.77 Published 1992 Journal Neurosci. Lett. Section Title Doc Link 1489400 Disease Relevance 0 Pain Relevance 0.29
A weak C-fiber input caused by noxious mechanical stimulation of the skin of one hindpaw did not induce expression of c-Fos, FosB, Krox-20 or Krox-24; but it did reduce the basal expressions of c-Jun and JunD in both the medial and lateral areas.
Gene_expression (expressions) of JunD in lateral areas associated with c fibre
2) Confidence 0.72 Published 2001 Journal Neuroscience Section Abstract Doc Link 11744254 Disease Relevance 0 Pain Relevance 0.73
However, in the medial thalamus it increased c-Jun and reduced the basal expression of JunD, whereas in the lateral thalamus it had no effect on c-Jun but again reduced the basal expression of JunD.
Gene_expression (expression) of JunD in medial associated with thalamus
3) Confidence 0.72 Published 2001 Journal Neuroscience Section Abstract Doc Link 11744254 Disease Relevance 0 Pain Relevance 0.74
However, in the medial thalamus it increased c-Jun and reduced the basal expression of JunD, whereas in the lateral thalamus it had no effect on c-Jun but again reduced the basal expression of JunD.
Gene_expression (expression) of JunD in medial associated with thalamus
4) Confidence 0.72 Published 2001 Journal Neuroscience Section Abstract Doc Link 11744254 Disease Relevance 0 Pain Relevance 0.76
Expression of JunD was inhibited in intralaminar and midline thalamic nuclei.
Gene_expression (Expression) of JunD in midline
5) Confidence 0.68 Published 1995 Journal Brain Res. Section Abstract Doc Link 8548308 Disease Relevance 0 Pain Relevance 0.51
The effect of a single injection of caffeine on the expression of c-fos, c-jun, junB, and junD, on activator protein 1 (AP-1) and on the levels of preproenkephalin mRNA in rat striatum was studied.
Gene_expression (expression) of junD in striatum
6) Confidence 0.68 Published 1995 Journal J. Neurosci. Section Abstract Doc Link 7751931 Disease Relevance 0 Pain Relevance 0
The present paper describes the effect of capsaicin-induced stressful stimulus on the expression of immediate early genes (IEGs) c-fos, c-jun, junB and junD in the hypothalamic paraventricular nucleus (PVN) and the central amygdaloid nucleus (ACe) using in situ hybridization.
Gene_expression (expression) of junD in nucleus associated with qutenza
7) Confidence 0.60 Published 1992 Journal Neuroreport Section Abstract Doc Link 1421086 Disease Relevance 0.30 Pain Relevance 0.13
METH injection caused similar increases in Jund expression on both the intact (2.2-fold) and lesioned (1.9-fold) striata of the hemiparkinsonian rats (Table 6).
Gene_expression (expression) of Jund
8) Confidence 0.60 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001483 Disease Relevance 0 Pain Relevance 0.21
Treatment with imipramine resulted in significant up-regulation of three (Glial cell line derived neurotrophic factor superfamily receptor alpha 2, Macrophage expressed gene 1, Tumor necrosis factor member 11), 13 (Nerve growth factor beta, tumor necrosis factor receptor regulator, Jun D proto-oncogene, Adenosine A1 receptor, Neurotrophic tyrosine kinase receptor type 2, Somatostatin receptor 5, Leptin receptor, Arrestin beta 1, Epsin 1, Caspase 8, Cyclin-dependent kinase 5, Synuclein alpha, Amyloid beta precursor protein), and five (Transforming growth factor beta 2, RAB6A member RAS oncogene family, Regucalcin, Syntaxin 11, Homogentisate 1, 2-dioxygenase) genes and down-regulation of five (Leukocyte cell derived chemotaxin 1, Phospholipase A2 activating protein, Mitogen-activated protein kinase), one (Interferon gamma), and two (Tumor necrosis factor alpha induced protein 6, Granzyme A) genes after one, three and seven days of treatment, respectively.
Gene_expression (expressed) of Jun D proto-oncogene in Nerve associated with necrosis, adenocard, nerve growth factor, cancer, alzheimer's dementia and somatostatin
9) Confidence 0.52 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC3009642 Disease Relevance 1.35 Pain Relevance 0.23
Finally, treatment with phenelzine resulted in up-regulation of three (Glial cell line derived neurotrophic factor superfamily receptor alpha 2, Macrophage expressed gene 1, Fyn proto-oncogene), 14 (Nerve growth factor beta, Midkine, Type 1 tumor necrosis factor receptor regulator, Jun D proto-oncogene, Adenosine A1 receptor, Leptin receptor, Adrenomedullin, Arrestin beta 1, Syntaxin 1A, Epsin 1, Caspase 8, Cyclin-dependent kinase 5, Synuclein alpha, Amyloid beta precursor protein), and five (Transforming growth factor beta 2, Growth differentiation factor 15, Regucalcin, Syntaxin 11, Homogentisate 1, 2-dioxygenase) genes and down-regulation of four (Immunoglobulin superfamily member 6, Secreted phosphoprotein 1, Phospholipase A2 activating protein, Tumor necrosis factor receptor superfamily member 6), three (Serum amyloid A 4, Apoptosis facilitator Bcl-2-like protein 14, Interferon gamma), and two (Tumor necrosis factor alpha induced protein 6, Granzyme A) genes after treatment for one, three and seven days, respectively (Table 1 and 2).
Gene_expression (expressed) of Jun D proto-oncogene in Nerve associated with necrosis, adenocard, nerve growth factor, cancer, alzheimer's dementia and apoptosis
10) Confidence 0.52 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC3009642 Disease Relevance 1.60 Pain Relevance 0.25
We have used the evoked expression of the immediate early gene-encoded proteins (c-Fos, Fos B, Jun B, Jun D, c-Jun and Krox-24) to monitor sensory processing in the hindbrain structures of rats undergoing somatic inflammation.
Gene_expression (expression) of Jun D in hindbrain associated with inflammation
11) Confidence 0.52 Published 1994 Journal Neuroscience Section Abstract Doc Link 8152540 Disease Relevance 0.33 Pain Relevance 0.19
Expression of the junD proto-oncogene in the rat spinal cord and skin following noxious cutaneous ultraviolet irradiation.
Gene_expression (Expression) of junD in skin associated with pain and spinal cord
12) Confidence 0.26 Published 1992 Journal Neurosci. Lett. Section Title Doc Link 1489400 Disease Relevance 0 Pain Relevance 0.29
A weak C-fiber input caused by noxious mechanical stimulation of the skin of one hindpaw did not induce expression of c-Fos, FosB, Krox-20 or Krox-24; but it did reduce the basal expressions of c-Jun and JunD in both the medial and lateral areas.
Gene_expression (expressions) of JunD in medial associated with c fibre
13) Confidence 0.24 Published 2001 Journal Neuroscience Section Abstract Doc Link 11744254 Disease Relevance 0 Pain Relevance 0.73
When neuronal cells are plated on top of the monolayers, the expression of Fra, c-Jun, JunD, and GFAP decreases in the astroglial cells.
Gene_expression (expression) of JunD in neuronal
14) Confidence 0.15 Published 1996 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8738155 Disease Relevance 0 Pain Relevance 0.08
We have observed that cultured glial cells express high basal levels of transcription factors, such as fos-related antigens (Fra), c-Jun, JunD, and cAMP responsive element binding protein (CREB).
Gene_expression (express) of JunD in glial cells
15) Confidence 0.15 Published 1996 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8738155 Disease Relevance 0 Pain Relevance 0.09

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