INT9482

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Context Info
Confidence 0.69
First Reported 1991
Last Reported 2011
Negated 2
Speculated 2
Reported most in Abstract
Documents 60
Total Number 62
Disease Relevance 9.95
Pain Relevance 18.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Jun) aging (Jun) nucleus (Jun)
DNA binding (Jun) transcription factor binding (Jun)
Anatomy Link Frequency
vagus nerve 12
ACe 12
neurons 12
spinal cord 11
striatum 8
Jun (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nerve growth factor 69 100.00 Very High Very High Very High
Hippocampus 36 100.00 Very High Very High Very High
Enkephalin 20 100.00 Very High Very High Very High
isoflurane 19 100.00 Very High Very High Very High
opiate 3 100.00 Very High Very High Very High
vagus nerve 90 99.98 Very High Very High Very High
Glutamate 25 99.98 Very High Very High Very High
qutenza 20 99.92 Very High Very High Very High
withdrawal 16 99.92 Very High Very High Very High
electroacupuncture 7 99.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Shock 3 100.00 Very High Very High Very High
Stress 27 99.98 Very High Very High Very High
Death 24 99.62 Very High Very High Very High
Benign Prostatic Hypertrophy 8 99.62 Very High Very High Very High
Ganglion Cysts 49 99.48 Very High Very High Very High
Cv Unclassified Under Development 133 99.16 Very High Very High Very High
Convulsion 5 99.14 Very High Very High Very High
Diabetes Mellitus 1 98.72 Very High Very High Very High
Nervous System Injury 7 98.60 Very High Very High Very High
Hypotension 6 98.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Similar to vagotomy, application of colchicine and vinblastine on to the intact vagus nerve induced expression of c-JUN and JUN D.
Positive_regulation (induced) of Gene_expression (expression) of JUN in vagus nerve associated with vagus nerve
1) Confidence 0.69 Published 1991 Journal Neuroscience Section Abstract Doc Link 1762686 Disease Relevance 0.15 Pain Relevance 0.38
Transection of the cervical sympathetic trunk induced expression of c-JUN and JUN D, but not of JUN B, in the preganglionic sympathetic neurons of thoracic spinal cord.
Positive_regulation (induced) of Gene_expression (expression) of JUN in sympathetic associated with spinal cord
2) Confidence 0.69 Published 1991 Journal Neuroscience Section Abstract Doc Link 1762686 Disease Relevance 0.13 Pain Relevance 0.37
We postulate that the expression of c-JUN and JUN D in axotomized neurons is induced by deprivation of a target-derived suppressor.
Positive_regulation (induced) of Gene_expression (expression) of JUN in neurons
3) Confidence 0.69 Published 1991 Journal Neuroscience Section Abstract Doc Link 1762686 Disease Relevance 0 Pain Relevance 0.24
Vagotomy induced the expression of c-JUN and JUN D in the nodose ganglion, dorsal motor nucleus of the vagus nerve and nucleus ambiguus, whereas JUN B was not expressed in these areas, c-JUN and JUN D appeared after 10 h in the nodose ganglion and after 24 h in the dorsal motor nucleus of the vagus nerve with a maximum of immunoreactivity after 48 h.
Spec (appeared) Positive_regulation (induced) of Gene_expression (expression) of JUN in nucleus associated with ganglion cysts and vagus nerve
4) Confidence 0.69 Published 1991 Journal Neuroscience Section Abstract Doc Link 1762686 Disease Relevance 0.19 Pain Relevance 0.21
In these neurons, expression of c-JUN was still enhanced after 60 days whereas JUN D had returned to basal level.
Positive_regulation (enhanced) of Gene_expression (expression) of JUN in neurons
5) Confidence 0.69 Published 1991 Journal Neuroscience Section Abstract Doc Link 1762686 Disease Relevance 0.12 Pain Relevance 0.35
Effects of capsaicin on induction of c-jun proto-oncogene expression in Fisher-344 rats by N-methyl-N'-nitro-N-nitrosoguanidine.
Positive_regulation (induction) of Gene_expression (expression) of c-jun associated with qutenza
6) Confidence 0.60 Published 1999 Journal Cancer Lett. Section Title Doc Link 10463771 Disease Relevance 0.28 Pain Relevance 0.59
The present results demonstrate that neurotransmitters released from splanchnic nerve terminals induce expression of c-fos, c-jun, and junB in adrenal chromaffin cells which results in increased AP-1 DNA binding activity.
Positive_regulation (induce) of Gene_expression (expression) of c-jun associated with neurotransmitter
7) Confidence 0.58 Published 1995 Journal J. Neurosci. Section Abstract Doc Link 7891139 Disease Relevance 0 Pain Relevance 0.58
In contrast, the expression of JUN D, which was present before stimulation in many spinal neurons, was increased after 4 h, reached its maximum after 8 h and thereafter remained elevated.
Positive_regulation (increased) of Gene_expression (expression) of JUN in neurons
8) Confidence 0.58 Published 1991 Journal Neurosci. Lett. Section Abstract Doc Link 1745403 Disease Relevance 0.07 Pain Relevance 0.18
Glutamate-induced cell death was related to an increase in expression of phospho-c-Jun.
Positive_regulation (increase) of Gene_expression (expression) of phospho-c-Jun associated with glutamate and death
9) Confidence 0.57 Published 2008 Journal J Neurosurg Anesthesiol Section Abstract Doc Link 18362774 Disease Relevance 0.57 Pain Relevance 0.58
Glutamate-induced c-Jun expression in neuronal PC12 cells: the effects of ketamine and propofol.
Positive_regulation (induced) of Gene_expression (expression) of c-Jun in neuronal associated with glutamate and ketamine
10) Confidence 0.57 Published 2008 Journal J Neurosurg Anesthesiol Section Title Doc Link 18362774 Disease Relevance 0.37 Pain Relevance 0.46
In the lateral thalamus the repeated stimulation again failed to induce c-Fos, but the expressions of FosB, c-Jun and Krox-24 were increased, and that of JunD was again reduced.
Positive_regulation (increased) of Gene_expression (expressions) of c-Jun in lateral associated with thalamus
11) Confidence 0.54 Published 2001 Journal Neuroscience Section Abstract Doc Link 11744254 Disease Relevance 0.08 Pain Relevance 0.57
Crush of the vagus nerve initially evoked an intense expression of c-JUN and JUN D, but in the course of regeneration the expression of c-JUN and JUN D had returned to more basal levels after 100 days.
Positive_regulation (returned) of Gene_expression (expression) of JUN in vagus nerve associated with vagus nerve
12) Confidence 0.50 Published 1991 Journal Neuroscience Section Abstract Doc Link 1762686 Disease Relevance 0.16 Pain Relevance 0.37
Vagotomy induced the expression of c-JUN and JUN D in the nodose ganglion, dorsal motor nucleus of the vagus nerve and nucleus ambiguus, whereas JUN B was not expressed in these areas, c-JUN and JUN D appeared after 10 h in the nodose ganglion and after 24 h in the dorsal motor nucleus of the vagus nerve with a maximum of immunoreactivity after 48 h.
Spec (appeared) Positive_regulation (induced) of Gene_expression (expression) of JUN in nucleus associated with ganglion cysts and vagus nerve
13) Confidence 0.50 Published 1991 Journal Neuroscience Section Abstract Doc Link 1762686 Disease Relevance 0.19 Pain Relevance 0.21
Transection of the cervical sympathetic trunk induced expression of c-JUN and JUN D, but not of JUN B, in the preganglionic sympathetic neurons of thoracic spinal cord.
Positive_regulation (induced) of Gene_expression (expression) of JUN in sympathetic associated with spinal cord
14) Confidence 0.50 Published 1991 Journal Neuroscience Section Abstract Doc Link 1762686 Disease Relevance 0.13 Pain Relevance 0.37
Crush of the vagus nerve initially evoked an intense expression of c-JUN and JUN D, but in the course of regeneration the expression of c-JUN and JUN D had returned to more basal levels after 100 days.
Positive_regulation (returned) of Gene_expression (expression) of JUN in vagus nerve associated with vagus nerve
15) Confidence 0.50 Published 1991 Journal Neuroscience Section Abstract Doc Link 1762686 Disease Relevance 0.17 Pain Relevance 0.37
Similar to vagotomy, application of colchicine and vinblastine on to the intact vagus nerve induced expression of c-JUN and JUN D.
Positive_regulation (induced) of Gene_expression (expression) of JUN in vagus nerve associated with vagus nerve
16) Confidence 0.50 Published 1991 Journal Neuroscience Section Abstract Doc Link 1762686 Disease Relevance 0.15 Pain Relevance 0.38
Crush of the vagus nerve initially evoked an intense expression of c-JUN and JUN D, but in the course of regeneration the expression of c-JUN and JUN D had returned to more basal levels after 100 days.
Positive_regulation (returned) of Gene_expression (expression) of JUN in vagus nerve associated with vagus nerve
17) Confidence 0.50 Published 1991 Journal Neuroscience Section Abstract Doc Link 1762686 Disease Relevance 0.16 Pain Relevance 0.37
Transection of the cervical sympathetic trunk induced expression of c-JUN and JUN D, but not of JUN B, in the preganglionic sympathetic neurons of thoracic spinal cord.
Positive_regulation (induced) of Gene_expression (expression) of JUN in sympathetic associated with spinal cord
18) Confidence 0.50 Published 1991 Journal Neuroscience Section Abstract Doc Link 1762686 Disease Relevance 0.13 Pain Relevance 0.37
We postulate that the expression of c-JUN and JUN D in axotomized neurons is induced by deprivation of a target-derived suppressor.
Positive_regulation (induced) of Gene_expression (expression) of JUN in neurons
19) Confidence 0.50 Published 1991 Journal Neuroscience Section Abstract Doc Link 1762686 Disease Relevance 0 Pain Relevance 0.24
Crush of the vagus nerve initially evoked an intense expression of c-JUN and JUN D, but in the course of regeneration the expression of c-JUN and JUN D had returned to more basal levels after 100 days.
Positive_regulation (returned) of Gene_expression (expression) of JUN in vagus nerve associated with vagus nerve
20) Confidence 0.50 Published 1991 Journal Neuroscience Section Abstract Doc Link 1762686 Disease Relevance 0.17 Pain Relevance 0.37

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