INT94826

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Context Info
Confidence 0.40
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 13
Disease Relevance 4.62
Pain Relevance 0.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (HBS1L) translation (HBS1L) GTPase activity (HBS1L)
Anatomy Link Frequency
blood 1
lymphocyte 1
pallidum 1
T cells 1
body 1
HBS1L (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 61 99.88 Very High Very High Very High
agonist 6 93.12 High High
nociceptor 6 75.00 Quite High
drug abuse 2 75.00 Quite High
opiate 3 68.72 Quite High
Cannabinoid 3 67.84 Quite High
Codeine 1 67.52 Quite High
Inflammation 6 8.80 Low Low
Pain 9 5.00 Very Low Very Low Very Low
imagery 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hepatitis 28 100.00 Very High Very High Very High
Anaemia 10 100.00 Very High Very High Very High
Hematological Disease 2 99.88 Very High Very High Very High
Thalassemia 2 99.56 Very High Very High Very High
Hepatitis C Virus Infection 16 98.28 Very High Very High Very High
Malaria 29 98.08 Very High Very High Very High
Recurrence 18 96.56 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 83 96.16 Very High Very High Very High
Communicable Diseases 5 93.96 High High
Mycobacterial Infection 50 93.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Further increase of the stimulus strength to 70 or 100 mA increased the eRFs only marginally.
Positive_regulation (increased) of eRFs
1) Confidence 0.40 Published 2002 Journal J. Neurophysiol. Section Abstract Doc Link 12364512 Disease Relevance 0 Pain Relevance 0.07
Fifty-milliampere stimuli increased the eRFs to 3.08 cm(2) in a concentric manner.
Positive_regulation (increased) of eRFs
2) Confidence 0.40 Published 2002 Journal J. Neurophysiol. Section Abstract Doc Link 12364512 Disease Relevance 0 Pain Relevance 0.07
The observed association of gametocytes with anaemia and subsequent erythropoietic response [5]–[7], [28]–[29] has yet to be explored genetically, despite a high prevalence of inherited blood disorders that induce anaemia, such as HbS and alpha-thalassaemia, in regions endemic for malaria [30].
Positive_regulation (induce) of HbS in blood associated with malaria, hematological disease, anaemia and thalassemia
3) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2894056 Disease Relevance 0.66 Pain Relevance 0.04
The Canadian Medical Association (CMA) policy recommends that "physicians who test positive for HBsAg cease activities of their practice that could expose patients to their body fluids until their practice has been reviewed by an expert committee" [22].
Positive_regulation (positive) of HBsAg in body
4) Confidence 0.07 Published 2001 Journal BMC Med Ethics Section Body Doc Link PMC59900 Disease Relevance 0.32 Pain Relevance 0
Serological tests revealed that 1,884 (4.4%) of individuals were positive for hepatitis B surface antigen (HBsAg), 737 (1.7%) for Treponema pallidum hemagglutination (TPHA) and only 83 (0.2%) for antibody to human immunodeficiency virus (anti-HIV).
Positive_regulation (positive) of HBsAg in pallidum associated with acquired immune deficiency syndrome or hiv infection and hepatitis
5) Confidence 0.04 Published 2000 Journal Southeast Asian J. Trop. Med. Public Health Section Abstract Doc Link 11289023 Disease Relevance 0.84 Pain Relevance 0.23
Thus, prevention of deoxygenation-induced HbS polymerization was associated with inhibition of deoxygenation-stimulated channel activity.


Positive_regulation (induced) of HbS
6) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806905 Disease Relevance 0 Pain Relevance 0
These results suggested that deoxygenation-activated elevation of [Ca2+]I in SS cells required both HbS polymerization and activation of a (pharmacologically defined) stretch-activated ion conductance.
Positive_regulation (required) of HbS
7) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806905 Disease Relevance 0.06 Pain Relevance 0
Future studies should lead to molecular identification of component polypeptide(s) of the deoxygenation-activated cation conductance, and more completely define the mechanism linking its activation to HbS polymerization.
Positive_regulation (activation) of HbS
8) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806905 Disease Relevance 0.52 Pain Relevance 0
PBMCs were thawed and stimulated using a set of 22 20-mers peptides (overlapping by 11 aa) that span the entire HBsAg protein sequence (1 ?
Positive_regulation (entire) of HBsAg
9) Confidence 0.03 Published 2007 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC1852106 Disease Relevance 0.33 Pain Relevance 0
For instance, CpG ODN have been shown to increase HBsAg Ig titers and Ab affinity, but the induction of HBsAg-specific T cells could not be detected in direct ex vivo assays (i.e. without any bias induced by in vitro lymphocyte proliferation) in immunized healthy individuals co-injected with 3 mg ISS [13] or with 1 mg CpG ODN [14], respectively.
Positive_regulation (induction) of HBsAg in lymphocyte
10) Confidence 0.03 Published 2007 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC1852106 Disease Relevance 0.21 Pain Relevance 0.05
Figure 4 shows the fold increase percentages of CD4+ T cells expressing at least one cytokine upon HBsAg stimulation on D29, D36, D57 and D85 versus D1 for each responder.
Positive_regulation (stimulation) of HBsAg in T cells associated with cytokine
11) Confidence 0.02 Published 2007 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC1852106 Disease Relevance 0 Pain Relevance 0.08
Eighty percent of the patients had CD4 count less than 200 cells/mm3.Fourteen (7.2%) were positive for HBsAg and only 4 (2.2 %) were positive for anti-HCV.
Positive_regulation (positive) of HBsAg associated with hepatitis c virus infection
12) Confidence 0.01 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2265547 Disease Relevance 1.16 Pain Relevance 0.07
Although, two of the eight remained HBsAg positive, both had undetectable DNA levels with normal LFT's.
Positive_regulation (remained) of HBsAg
13) Confidence 0.01 Published 2006 Journal Ann Clin Microbiol Antimicrob Section Body Doc Link PMC1459192 Disease Relevance 0.52 Pain Relevance 0

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